Search Results - "Haxell, Thomas F.N."

Organomediated Morita−Baylis−Hillman Cyclization Reactions by Krafft, Marie E, Haxell, Thomas F. N

“…We have developed the Morita−Baylis−Hillman reaction to include, for the first time in a completely organomediated process, intramolecular examples bearing…”
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Discovery of substituted benzamides as follicle stimulating hormone receptor allosteric modulators by Yu, Henry N., Richardson, Thomas E., Nataraja, Selva, Fischer, David J., Sriraman, Venkataraman, Jiang, Xuliang, Bharathi, Pandi, Foglesong, Robert J., Haxell, Thomas F.N., Heasley, Brian H., Jenks, Mathew, Li, Jane, Dugas, Melanie S., Collis, Regina, Tian, Hui, Palmer, Stephen, Goutopoulos, Andreas

“…Follicle-stimulating hormone (FSH), acting on its receptor (FSHR), plays a pivotal role in the stimulation of follicular development and maturation. Multiple…”
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Dynamic Thermodynamic and Dynamic Kinetic Resolution of 2-Lithiopyrrolidines by Coldham, Iain, Dufour, Samuel, Haxell, Thomas F. N, Patel, Jignesh J, Sanchez-Jimenez, Graciela

“…Dynamic resolution has been studied as a method for the asymmetric synthesis of 2-substituted pyrrolidines. Highly enantioselective electrophilic substitutions…”
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The intramolecular Morita–Baylis–Hillman-type alkylation reaction by Cran, John W., Krafft, Marie E., Seibert, Kimberly A., Haxell, Thomas F.N., Wright, James A., Hirosawa, Chitaru, Abboud, Khalil A.

“…From the initial development of a homologous Morita–Baylis–Hillman reaction utilizing epoxides as electrophiles, the method was expanded to enable the…”
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Mechanistic Implications in the Morita−Baylis−Hillman Alkylation:  Isolation and Characterization of an Intermediate by Krafft, Marie E, Haxell, Thomas F. N, Seibert, Kimberly A, Abboud, Khalil A

“…An intermediate phosphonium salt has never been isolated from the Morita−Baylis−Hillman (MBH) reaction. Due to the weakly basic counterion produced in the MBH…”
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Dynamic resolution of N-alkyl-2-lithiopyrrolidines with the chiral ligand (−)-sparteine by Coldham, Iain, Dufour, Samuel, Haxell, Thomas F.N., Vennall, Graham P.

“…A selection of 2-lithiopyrrolidines with different N-alkyl-substituents were prepared and tested for their dynamic resolution in the presence of the chiral…”
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Enantioselective Synthesis of Substituted Pyrrolidines by Dynamic Resolution by Coldham, Iain, Dufour, Samuel, Haxell, Thomas F. N., Howard, Steven, Vennall, Graham P.

“…Not restricted to allylic or benzylic derivatives: The dynamic resolution of chiral organolithium species in the presence of a chiral ligand, L*, followed by…”
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Preparation of diamines by lithiation-substitution of imidazolidines and pyrimidines by Ashweek, Neil J, Coldham, Iain, Haxell, Thomas F, Howard, Steven

“…The synthesis of chiral 1,2-diamines and 1,3-diamines was achieved from the unsubstituted diamines by way of N-tert-butoxycarbonyl (Boc) substituted…”
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Synthesis of Chiral 1,2-Diamines by Asymmetric Lithiation−Substitution by Coldham, Iain, Copley, Royston C. B, Haxell, Thomas F. N, Howard, Steven

“…The imidazolidine (tetrahydroimidazole) 2, prepared in one step from N-iso-propylethylenediamine, was subjected to asymmetric lithiation and substitution using…”
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