Search Results - "Hawthorne, Ian J"

The Necrobiology of Mesenchymal Stromal Cells Affects Therapeutic Efficacy by Weiss, Daniel J, English, Karen, Krasnodembskaya, Anna, Isaza-Correa, Johana M, Hawthorne, Ian J, Mahon, Bernard P

“…Rapid progress is occurring in understanding the mechanisms underlying mesenchymal stromal cell (MSC)-based cell therapies (MSCT). However, the results of…”
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IFN‐γ and PPARδ influence the efficacy and retention of multipotent adult progenitor cells in graft vs host disease by Carty, Fiona, Dunbar, Hazel, Hawthorne, Ian J., Ting, Anthony E., Stubblefield, Samantha R., Van't Hof, Wouter, English, Karen

“…Cell‐based therapy for the treatment of inflammatory disorders has focused on the application of mesenchymal stromal cells (MSCs) and multipotent adult…”
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Carbon monoxide licensing of MSCs enhances their efficacy through autophagy-mediated miRNA mechanisms by Dunbar, Hazel, Hawthorne, Ian J, English, Karen

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Blockade of MIF biological activity ameliorates house dust mite‐induced allergic airway inflammation in humanized MIF mice by Dunbar, Hazel, Hawthorne, Ian J., Tunstead, Courteney, Armstrong, Michelle E., Donnelly, Seamas C., English, Karen

“…Macrophage migration inhibitory factor (MIF) expression is controlled by a functional promoter polymorphism, where the number of tetranucleotide repeats…”
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The human MIF polymorphism CATT 7 enhances pro-inflammatory macrophage polarization in a clinically relevant model of allergic airway inflammation by Dunbar, Hazel, Hawthorne, Ian J, McNamee, Eóin N, Armstrong, Michelle E, Donnelly, Seamas C, English, Karen

“…High level expression of the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) has been associated with severe asthma. The role of MIF and…”
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The human MIF polymorphism CATT7 enhances pro‐inflammatory macrophage polarization in a clinically relevant model of allergic airway inflammation by Dunbar, Hazel, Hawthorne, Ian J., McNamee, Eóin N., Armstrong, Michelle E., Donnelly, Seamas C., English, Karen

“…High level expression of the pro‐inflammatory cytokine macrophage migration inhibitory factor (MIF) has been associated with severe asthma. The role of MIF and…”
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The ARDS microenvironment enhances MSC-induced repair via VEGF in experimental acute lung inflammation by Tunstead, Courteney, Volkova, Evelina, Dunbar, Hazel, Hawthorne, Ian J, Bell, Alison, Crowe, Louise, Masterson, Joanne C, Dos Santos, Claudia C, McNicholas, Bairbre, Laffey, John G, English, Karen

“…Clinical trials investigating the potential of mesenchymal stromal cells (MSCs) for the treatment of inflammatory diseases, such as acute respiratory distress…”
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Human macrophage migration inhibitory factor potentiates mesenchymal stromal cell efficacy in a clinically relevant model of allergic asthma by Hawthorne, Ian J., Dunbar, Hazel, Tunstead, Courteney, Schorpp, Tamara, Weiss, Daniel J., Enes, Sara Rolandsson, dos Santos, Claudia C., Armstrong, Michelle E., Donnelly, Seamas C., English, Karen

“…Current asthma therapies focus on reducing symptoms but fail to restore existing structural damage. Mesenchymal stromal cell (MSC) administration can…”
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The VEGF‐Mediated Cytoprotective Ability of MIF‐Licensed Mesenchymal Stromal Cells in House Dust Mite‐Induced Epithelial Damage by Dunbar, Hazel, Hawthorne, Ian J., Tunstead, Courteney, Dunlop, Molly, Volkova, Evelina, Weiss, Daniel J., Santos, Claudia C. dos, Armstrong, Michelle E., Donnelly, Seamas C., English, Karen

“…ABSTRACT Enhancing mesenchymal stromal cell (MSC) therapeutic efficacy through licensing with proinflammatory cytokines is now well established. We have…”
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Mesenchymal stromal cells dampen trained immunity in house dust mite-primed macrophages expressing human macrophage migration inhibitory factor polymorphism by Dunbar, Hazel, Hawthorne, Ian J., Tunstead, Courteney, McNamee, Eóin N., Weiss, Daniel J., Armstrong, Michelle E., Donnelly, Seamas C., English, Karen

“…Trained immunity results in long-term immunological memory, provoking a faster and greater immune response when innate immune cells encounter a secondary,…”
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IFN#8208;γ and PPARδ influence the efficacy and retention of multipotent adult progenitor cells in graft vs host disease by Carty, Fiona, Dunbar, Hazel, Hawthorne, Ian J, Ting, Anthony E, Stubblefield, Samantha R, Van'T Hof, Wouter, English, Karen

“…Cell‐based therapy for the treatment of inflammatory disorders has focused on the application of mesenchymal stromal cells (MSCs) and multipotent adult…”
Get full text