Search Results - "Haws, Laurie"

Letter to the editor of environmental pollution: In regard to Wan et al. (2024) “GenX caused liver injury and potential hepatocellular carcinoma of mice via drinking water even at environmental concentration” by Thompson, Chad M., Heintz, Melissa M., Cullen, John M., Haws, Laurie C.

“…•Wan et al. (2024) report mouse liver injury at low GenX (HFPO-DA) concentrations.•There are serious deficiencies in the liver histopathology analyses…”
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Assessment of the Mode of Action Underlying the Effects of GenX in Mouse Liver and Implications for Assessing Human Health Risks by Chappell, Grace A., Thompson, Chad M., Wolf, Jeffrey C., Cullen, John M., Klaunig, James E., Haws, Laurie C.

“…GenX is an alternative to environmentally persistent long-chain perfluoroalkyl and polyfluoroalkyl substances. Mice exposed to GenX exhibit liver hypertrophy,…”
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Assessment of Cr(VI)-induced cytotoxicity and genotoxicity using high content analysis by Thompson, Chad M, Fedorov, Yuriy, Brown, Daniel D, Suh, Mina, Proctor, Deborah M, Kuriakose, Liz, Haws, Laurie C, Harris, Mark A

“…Oral exposure to high concentrations of hexavalent chromium [Cr(VI)] induces intestinal redox changes, villus cytotoxicity, crypt hyperplasia, and intestinal…”
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Assessment of the mode of action underlying development of liver lesions in mice following oral exposure to HFPO-DA and relevance to humans by Heintz, Melissa M, Haws, Laurie C, Klaunig, James E, Cullen, John M, Thompson, Chad M

“…Abstract HFPO-DA (ammonium, 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoate) is a short-chain polyfluorinated alkyl substance (PFAS) used in the…”
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Assessment of the genotoxicity of tert‐butyl alcohol in an in vivo thyroid comet assay by Thompson, Chad M., Dewhurst, Nicole, Moundous, Dmitri, Borghoff, Susan J., Haws, Laurie C., Vasquez, Marie Z.

“…Chronic exposure to high (20,000 ppm) concentrations of tert‐butyl alcohol (TBA) in drinking water, equivalent to ~2100 mg/kg bodyweight per day, is associated…”
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Systematic evaluation of mechanistic data in assessing in utero exposures to trichloroethylene and development of congenital heart defects by Urban, Jonathan D., Wikoff, Daniele S., Chappell, Grace A., Harris, Craig, Haws, Laurie C.

“…The hypothesis that in utero exposures to low levels of trichloroethylene (TCE) may increase the risk of congenital heart defects (CHDs) in offspring remains a…”
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Comparison of transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in mouse, rat, and pooled human hepatocytes by Heintz, Melissa M, Klaren, William D, East, Alexander W, Haws, Laurie C, McGreal, Steven R, Campbell, Rebecca R, Thompson, Chad M

“…Like many per- or polyfluorinated alkyl substances (PFAS), toxicity studies with HFPO-DA (ammonium, 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate), a…”
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Comparison of transcriptomic profiles between HFPO-DA and prototypical PPARα, PPARγ, and cytotoxic agents in wild-type and PPARα knockout mouse hepatocytes by Heintz, Melissa M, Klaren, William D, East, Alexander W, Haws, Laurie C, McGreal, Steven R, Campbell, Rebecca R, Thompson, Chad M

“…Recent in vitro transcriptomic analyses for the short-chain polyfluoroalkyl substance, HFPO-DA (ammonium,…”
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Assessment of Mouse Liver Histopathology Following Exposure to HFPO-DA With Emphasis on Understanding Mechanisms of Hepatocellular Death by Thompson, Chad M., Heintz, Melissa M., Wolf, Jeffrey C., Cheru, Roza, Haws, Laurie C., Cullen, John M.

“…Ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate (HFPO-DA) is a short chain member of per- and polyfluoroalkyl substances (PFAS). To better…”
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Development of an oral reference dose for the perfluorinated compound GenX by Thompson, Chad M., Fitch, Seneca E., Ring, Caroline, Rish, William, Cullen, John M., Haws, Laurie C.

“…Ammonium 2,3,3,3‐tetrafluoro‐2‐(heptafluoropropoxy)‐propanoate, also known as GenX, is a processing aid used in the manufacture of fluoropolymers. GenX is one…”
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Development of a Range of Plausible Noncancer Toxicity Values for 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Based on Effects on Sperm Count: Application of Systematic Review Methods and Quantitative Integration of Dose Response Using Meta-Regression by Wikoff, Daniele S, Urban, Jonathan D, Ring, Caroline, Britt, Janice, Fitch, Seneca, Budinsky, Robert, Haws, Laurie C

“…Abstract Regulatory agencies have derived noncancer toxicity values for 2,3,7,8-tetrachlorodibenzo-p-dioxin based on reduced sperm counts relying on single…”
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Development of updated RfD and RfC values for medium carbon range aromatic and aliphatic total petroleum hydrocarbon fractions by Thompson, Chad M., Bhat, Virunya S., Brorby, Gregory P., Haws, Laurie C.

“…Using total petroleum hydrocarbon (TPH) measurements as a tool for assessing potential human health risks associated with exposures to petroleum products in…”
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The 2005 World Health Organization Reevaluation of Human and Mammalian Toxic Equivalency Factors for Dioxins and Dioxin-Like Compounds by Van den Berg, Martin, Birnbaum, Linda S., Denison, Michael, De Vito, Mike, Farland, William, Feeley, Mark, Fiedler, Heidelore, Hakansson, Helen, Hanberg, Annika, Haws, Laurie, Rose, Martin, Safe, Stephen, Schrenk, Dieter, Tohyama, Chiharu, Tritscher, Angelika, Tuomisto, Jouko, Tysklind, Mats, Walker, Nigel, Peterson, Richard E.

“…In June 2005, a World Health Organization (WHO)-International Programme on Chemical Safety expert meeting was held in Geneva during which the toxic equivalency…”
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A chronic oral reference dose for hexavalent chromium-induced intestinal cancer by Thompson, Chad M., Kirman, Christopher R., Proctor, Deborah M., Haws, Laurie C., Suh, Mina, Hays, Sean M., Hixon, J. Gregory, Harris, Mark A.

“…ABSTRACT High concentrations of hexavalent chromium [Cr(VI)] in drinking water induce villous cytotoxicity and compensatory crypt hyperplasia in the small…”
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Evaluation of Transcriptomic Responses in Livers of Mice Exposed to the Short-Chain PFAS Compound HFPO-DA by Heintz, Melissa M., Chappell, Grace A., Thompson, Chad M., Haws, Laurie C.

“…HFPO-DA (ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate; CASRN 62037-80-3) is a component of the GenX technology platform used as a…”
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Role of Risk of Bias in Systematic Review for Chemical Risk Assessment: A Case Study in Understanding the Relationship Between Congenital Heart Defects and Exposures to Trichloroethylene by Wikoff, Daniele, Urban, Jon D., Harvey, Seneca, Haws, Laurie C.

“…The National Academy of Science has recommended that a risk of bias (RoB; credibility of the link between exposure and outcome) assessment be conducted on…”
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Assessment of the mode of action underlying development of rodent small intestinal tumors following oral exposure to hexavalent chromium and relevance to humans by Thompson, Chad M., Proctor, Deborah M., Suh, Mina, Haws, Laurie C., Kirman, Christopher R., Harris, Mark A.

“…Abstract Chronic exposure to high concentrations of hexavalent chromium (Cr(VI)) in drinking water causes intestinal adenomas and carcinomas in mice, but not…”
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Ten factors for considering the mode of action of Cr(VI)-induced gastrointestinal tumors in rodents by Thompson, Chad M., Suh, Mina, Proctor, Deborah M., Haws, Laurie C., Harris, Mark A.

“…•Hexavalent chromium, Cr(VI), induces intestinal tumors in mice.•Eastmond enumerated 10 factors for determining a mutagenic mode of action.•These 10 factors…”
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Investigation of the mode of action underlying the tumorigenic response induced in B6C3F1 mice exposed orally to hexavalent chromium by Thompson, Chad M, Proctor, Deborah M, Haws, Laurie C, Hébert, Charles D, Grimes, Sheila D, Shertzer, Howard G, Kopec, Anna K, Hixon, J Gregory, Zacharewski, Timothy R, Harris, Mark A

“…Chronic ingestion of high concentrations of hexavalent chromium [Cr(VI)] in drinking water induces intestinal tumors in mice. To investigate the mode of action…”
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Development of toxicity values and exposure estimates for tetrabromobisphenol A: application in a margin of exposure assessment by Wikoff, Daniele, Thompson, Chad, Perry, Camarie, White, Matthew, Borghoff, Susan, Fitzgerald, Lauren, Haws, Laurie C.

“…Tetrabromobisphenol A (TBBPA) is used in a diverse array of products to improve fire safety. The National Toxicology Program (NTP) recently completed a 2‐year…”
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