Search Results - "Hawley, Ben R"

The roles of RNA in DNA double-strand break repair by Bader, Aldo S., Hawley, Ben R., Wilczynska, Ania, Bushell, Martin

“…Effective DNA repair is essential for cell survival: a failure to correctly repair damage leads to the accumulation of mutations and is the driving force for…”
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Drosha drives the formation of DNA:RNA hybrids around DNA break sites to facilitate DNA repair by Lu, Wei-Ting, Hawley, Ben R., Skalka, George L., Baldock, Robert A., Smith, Ewan M., Bader, Aldo S., Malewicz, Michal, Watts, Felicity Z., Wilczynska, Ania, Bushell, Martin

“…The error-free and efficient repair of DNA double-stranded breaks (DSBs) is extremely important for cell survival. RNA has been implicated in the resolution of…”
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Identification of the m6Am Methyltransferase PCIF1 Reveals the Location and Functions of m6Am in the Transcriptome by Boulias, Konstantinos, Toczydłowska-Socha, Diana, Hawley, Ben R., Liberman, Noa, Takashima, Ken, Zaccara, Sara, Guez, Théo, Vasseur, Jean-Jacques, Debart, Françoise, Aravind, L., Jaffrey, Samie R., Greer, Eric Lieberman

“…mRNAs are regulated by nucleotide modifications that influence their cellular fate. Two of the most abundant modified nucleotides are N6-methyladenosine (m6A),…”
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The emerging role of RNAs in DNA damage repair by Hawley, Ben R, Lu, Wei-Ting, Wilczynska, Ania, Bushell, Martin

“…Many surveillance and repair mechanisms exist to maintain the integrity of our genome. All of the pathways described to date are controlled exclusively by…”
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DDX17 is required for efficient DSB repair at DNA:RNA hybrid deficient loci by Bader, Aldo S, Luessing, Janna, Hawley, Ben R, Skalka, George L, Lu, Wei-Ting, Lowndes, Noel F, Bushell, Martin

“…Proteins with RNA-binding activity are increasingly being implicated in DNA damage responses (DDR). Additionally, DNA:RNA-hybrids are rapidly generated around…”
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The emerging role of RNAs in DNA damage repair by Hawley, Ben R, Lu, Wei-Ting, Wilczynska, Ania, Bushell, Martin

“…This corrects the article DOI: 10.1038/cdd.2017.16…”
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YTHDC2 control of gametogenesis requires helicase activity but not m6A binding by Saito, Yuhki, Hawley, Ben R, Puno, M Rhyan, Sarathy, Shreya N, Lima, Christopher D, Jaffrey, Samie R, Darnell, Robert B, Keeney, Scott, Jain, Devanshi

“…In this study, Saito et al. sought to understand how the N 6 -methyladenosine (m 6 A) reader and RNA helicase YTHDC2 switches cells from mitotic to meiotic…”
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YTHDC2 control of gametogenesis requires helicase activity but not m 6 A binding by Saito, Yuhki, Hawley, Ben R, Puno, M Rhyan, Sarathy, Shreya N, Lima, Christopher D, Jaffrey, Samie R, Darnell, Robert B, Keeney, Scott, Jain, Devanshi

“…Mechanisms regulating meiotic progression in mammals are poorly understood. The -methyladenosine (m A) reader and 3' → 5' RNA helicase YTHDC2 switches cells…”
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Transcriptome-Wide Mapping of m 6 A and m 6 Am at Single-Nucleotide Resolution Using miCLIP by Hawley, Ben R, Jaffrey, Samie R

“…The most prevalent modified base in mRNA, N -methyladenosine (m A), is found in several thousand transcripts, typically near the stop codon, although it can…”
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The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112 by van Tran, Nhan, Ernst, Felix G M, Hawley, Ben R, Zorbas, Christiane, Ulryck, Nathalie, Hackert, Philipp, Bohnsack, Katherine E, Bohnsack, Markus T, Jaffrey, Samie R, Graille, Marc, Lafontaine, Denis L J

“…Abstract N6-methyladenosine (m6A) has recently been found abundantly on messenger RNA and shown to regulate most steps of mRNA metabolism. Several important…”
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FTO controls reversible m6Am RNA methylation during snRNA biogenesis by Mauer, Jan, Sindelar, Miriam, Despic, Vladimir, Guez, Théo, Hawley, Ben R., Vasseur, Jean-Jacques, Rentmeister, Andrea, Gross, Steven S., Pellizzoni, Livio, Debart, Françoise, Goodarzi, Hani, Jaffrey, Samie R.

“…Small nuclear RNAs (snRNAs) are core spliceosome components and mediate pre-mRNA splicing. Here we show that snRNAs contain a regulated and reversible…”
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Erratum: The emerging role of RNAs in DNA damage repair by Hawley, Ben R, Lu, Wei-Ting, Wilczynska, Ania, Bushell, Martin

“…Correction to: Cell Death and Differentiation (2017) 24, 580–587; doi:10.1038/cdd.2017.16; published online 24 February 2017 Since the publication of this…”
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FTO controls reversible m 6 Am RNA methylation during snRNA biogenesis by Mauer, Jan, Sindelar, Miriam, Despic, Vladimir, Guez, Théo, Hawley, Ben R, Vasseur, Jean-Jacques, Rentmeister, Andrea, Gross, Steven S, Pellizzoni, Livio, Debart, Françoise, Goodarzi, Hani, Jaffrey, Samie R

“…Small nuclear RNAs (snRNAs) are core spliceosome components and mediate pre-mRNA splicing. Here we show that snRNAs contain a regulated and reversible…”
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Identification of the m 6 Am Methyltransferase PCIF1 Reveals the Location and Functions of m 6 Am in the Transcriptome by Boulias, Konstantinos, Toczydłowska-Socha, Diana, Hawley, Ben R, Liberman, Noa, Takashima, Ken, Zaccara, Sara, Guez, Théo, Vasseur, Jean-Jacques, Debart, Françoise, Aravind, L, Jaffrey, Samie R, Greer, Eric Lieberman

“…mRNAs are regulated by nucleotide modifications that influence their cellular fate. Two of the most abundant modified nucleotides are N -methyladenosine (m A),…”
Get full text