Search Results - "Hawkins, R. A."

Safety and tolerability of putaminal AADC gene therapy for Parkinson disease by CHRISTINE, C. W, STARR, P. A, LARSON, P. S, EBERLING, J. L, JAGUST, W. J, HAWKINS, R. A, VANBROCKLIN, H. F, WRIGHT, J. F, BANKIEWICZ, K. S, AMINOFF, M. J

“…In Parkinson disease (PD), the benefit of levodopa therapy becomes less marked over time, perhaps because degeneration of nigrostrial neurons causes…”
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Optofluidic analysis system for amplification-free, direct detection of Ebola infection by Cai, H., Parks, J. W., Wall, T. A., Stott, M. A., Stambaugh, A., Alfson, K., Griffiths, A., Mathies, R. A., Carrion, R., Patterson, J. L., Hawkins, A. R., Schmidt, H.

“…The massive outbreak of highly lethal Ebola hemorrhagic fever in West Africa illustrates the urgent need for diagnostic instruments that can identify and…”
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On demand delivery and analysis of single molecules on a programmable nanopore-optofluidic device by Rahman, M., Stott, M. A., Harrington, M., Li, Y., Sampad, M. J. N., Lancaster, L., Yuzvinsky, T. D., Noller, H. F., Hawkins, A. R., Schmidt, H.

“…Nanopore-based single nanoparticle detection has recently emerged as a vibrant research field with numerous high-impact applications. Here, we introduce a…”
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3× multiplexed detection of antibiotic resistant plasmids with single molecule sensitivity by Meena, G G, Hanson, R L, Wood, R L, Brown, O T, Stott, M A, Robison, R A, Pitt, W G, Woolley, A T, Hawkins, A R, Schmidt, H

“…Bacterial pathogens resistant to antibiotics have become a serious health threat. Those species which have developed resistance against multiple drugs such as…”
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Inducing apoptosis of cancer cells using small-molecule plant compounds that bind to GRP78 by Martin, S, Lamb, H K, Brady, C, Lefkove, B, Bonner, M Y, Thompson, P, Lovat, P E, Arbiser, J L, Hawkins, A R, Redfern, C P F

“…Background: Glucose regulated protein 78 (GRP78) functions as a sensor of endoplasmic reticulum (ER) stress. The aim of this study was to test the hypothesis…”
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Intrinsic spin dynamics in optically excited nanoscale magnetic tunnel junction arrays restored by dielectric coating by Jaris, M., Yahagi, Y., Mahato, B. K., Dhuey, S., Cabrini, S., Nikitin, V., Stout, J., Hawkins, A. R., Schmidt, H.

“…We report the all-optical observation of intrinsic spin dynamics and extraction of magnetic material parameters from arrays of sub-100 nm spin-transfer torque…”
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Crystal structure of the dimer of two essential Salmonella typhimurium proteins, YgjD & YeaZ and calorimetric evidence for the formation of a ternary YgjD–YeaZ–YjeE complex by Nichols, C. E., Lamb, H.K., Thompson, P., Omari, K. El, Lockyer, M., Charles, I., Hawkins, A. R., Stammers, D. K.

“…YgjD from COG0533 is amongst a small group of highly conserved proteins present in all three domains of life. Various roles and biochemical functions…”
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Ultrasensitive detection of SARS-CoV-2 RNA and antigen using single-molecule optofluidic chip by Meena, G. G., Stambaugh, A. M., Ganjalizadeh, V., Stott, M. A., Hawkins, A. R., Schmidt, H.

“…Nucleic acids and proteins are the two most important target types used in molecular diagnostics. In many instances, simultaneous sensitive and accurate…”
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Optofluidic particle concentration by a long-range dual-beam trap by Kühn, S, Lunt, E J, Phillips, B S, Hawkins, A R, Schmidt, H

“…Ultrahigh sensitivity detection of particles in solution implies the ability to detect at very low concentrations. At the single-particle level, this is…”
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Apoptotic death of pancreatic cancer cells induced by polyunsaturated fatty acids varies with double bond number and involves an oxidative mechanism by Hawkins, R. A., Sangster, Kathryn, Arends, M. J.

“…Polyunsaturated fatty acids (PUFAs), reported to be cytotoxic at micromolar concentrations for cancer cells in vitroand in vivo, are currently being tested in…”
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Multiplexed efficient on-chip sample preparation and sensitive amplification-free detection of Ebola virus by Du, K., Cai, H., Park, M., Wall, T.A., Stott, M.A., Alfson, K.J., Griffiths, A., Carrion, R., Patterson, J.L., Hawkins, A.R., Schmidt, H., Mathies, R.A.

“…An automated microfluidic sample preparation multiplexer (SPM) has been developed and evaluated for Ebola virus detection. Metered air bubbles controlled by…”
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7X multiplexed, optofluidic detection of nucleic acids for antibiotic-resistance bacterial screening by Meena, G. G., Wall, T. A., Stott, M. A., Brown, O., Robison, R., Hawkins, A. R., Schmidt, H.

“…Rapid and accurate diagnosis of bacterial infections resistant to multiple antibiotics requires development of new bio-sensors for differentiated detection of…”
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Cavity enhancement of the magneto-optic Kerr effect for optical studies of magnetic nanostructures by Qureshi, N., Schmidt, H., Hawkins, A. R.

“…We present a study of cavity enhancement of the magneto-optic Kerr effect using dielectric multilayers in order to facilitate optical studies of individual…”
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In vivo hippocampal glucose metabolism in mesial temporal lobe epilepsy by KNOWLTON, R. C, LAXER, K. D, KLEIN, G, SAWRIE, S, ENDE, G, HAWKINS, R. A, AASSAR, O. S, SOOHOO, K, WONG, S, BARBARO, N

“…The appearance of decreased 2-[(18)F]fluoro-2-deoxy-D-glucose (FDG) uptake in the mesial temporal region in temporal lobe epilepsy may simply reflect loss of…”
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The structure of the negative transcriptional regulator NmrA reveals a structural superfamily which includes the short-chain dehydrogenase/reductases by Stammers, D.K., Ren, J., Leslie, K., Nichols, C.E., Lamb, H.K., Cocklin, S., Dodds, A., Hawkins, A.R.

“…NmrA is a negative transcriptional regulator involved in the post‐translational modulation of the GATA‐type transcription factor AreA, forming part of a system…”
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A Critical Role for Extracellular DNA in Dental Plaque Formation by Rostami, N., Shields, R.C., Yassin, S.A., Hawkins, A.R., Bowen, L., Luo, T.L., Rickard, A.H., Holliday, R., Preshaw, P.M., Jakubovics, N.S.

“…Extracellular DNA (eDNA) has been identified in the matrix of many different monospecies biofilms in vitro, including some of those produced by oral bacteria…”
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Planar thin film device for capillary electrophoresis by Peeni, B A, Conkey, D B, Barber, J P, Kelly, R T, Lee, M L, Woolley, A T, Hawkins, A R

“…Hollow tubular microfluidic channels were fabricated on quartz substrates using sacrificial layer, planar micromachining processes. The channels were created…”
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Effect of eicosapentaenoic acid and other fatty acids on the growth in vitro of human pancreatic cancer cell lines by FALCONER, J. S, ROSS, J. A, FEARON, K. C. H, HAWKINS, R. A, O'RIORDAIN, M. G, CARTER, D. C

“…A number of polyunsaturated fatty acids have been shown to inhibit the growth of malignant cells in vitro. To investigate whether fatty acids modify the growth…”
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Metastatic head and neck cancer: role and usefulness of FDG PET in locating occult primary tumors by AAssar, O S, Fischbein, N J, Caputo, G R, Kaplan, M J, Price, D C, Singer, M I, Dillon, W P, Hawkins, R A

“…To assess the usefulness of 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) of the head and neck in locating occult primary…”
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On-chip wavelength multiplexed detection of cancer DNA biomarkers in blood by Cai, H., Stott, M. A., Ozcelik, D., Parks, J. W., Hawkins, A. R., Schmidt, H.

“…We have developed an optofluidic analysis system that processes biomolecular samples starting from whole blood and then analyzes and identifies multiple…”
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