Search Results - "Hawkins, Philip"

Systemic amyloidosis by Wechalekar, Ashutosh D, Dr, Gillmore, Julian D, FRCP, Hawkins, Philip N, FMedSci

“…Summary Tissue deposition of protein fibrils causes a group of rare diseases called systemic amyloidoses. This Seminar focuses on changes in their…”
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Cardiac amyloidosis by Martinez-Naharro, Ana, Hawkins, Philip N, Fontana, Marianna

“…Systemic amyloidosis comprises an uncommon group of disorders caused by the extracellular deposition of misfolded proteins in various organs. Cardiac amyloid…”
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EULAR recommendations for the management of familial Mediterranean fever by Ozen, Seza, Demirkaya, Erkan, Erer, Burak, Livneh, Avi, Ben-Chetrit, Eldad, Giancane, Gabriella, Ozdogan, Huri, Abu, Illana, Gattorno, Marco, Hawkins, Philip N, Yuce, Sezin, Kallinich, Tilmann, Bilginer, Yelda, Kastner, Daniel, Carmona, Loreto

“…Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease, but many rheumatologists are not well acquainted with its management…”
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Impact of Earlier Diagnosis in Cardiac ATTR Amyloidosis Over the Course of 20 Years by Ioannou, Adam, Patel, Rishi K., Razvi, Yousuf, Porcari, Aldostefano, Sinagra, Gianfranco, Venneri, Lucia, Bandera, Francesco, Masi, Ambra, Williams, Georgina E., O’Beara, Sophie, Ganesananthan, Sharmananthan, Massa, Paolo, Knight, Daniel, Martinez-Naharro, Ana, Kotecha, Tushar, Chacko, Liza, Brown, James, Rauf, Muhammad U., Manisty, Charlotte, Moon, James, Lachmann, Helen, Wechelakar, Ashutosh, Petrie, Aviva, Whelan, Carol, Hawkins, Philip N., Gillmore, Julian D., Fontana, Marianna

“…Diagnostic and therapeutic advances have led to much greater awareness of transthyretin cardiac amyloidosis (ATTR-CA). We aimed to characterize changes in the…”
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Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis by Adams, David, Gonzalez-Duarte, Alejandra, O’Riordan, William D, Yang, Chih-Chao, Ueda, Mitsuharu, Kristen, Arnt V, Tournev, Ivailo, Schmidt, Hartmut H, Coelho, Teresa, Berk, John L, Lin, Kon-Ping, Vita, Giuseppe, Attarian, Shahram, Planté-Bordeneuve, Violaine, Mezei, Michelle M, Campistol, Josep M, Buades, Juan, Brannagan, Thomas H, Kim, Byoung J, Oh, Jeeyoung, Parman, Yesim, Sekijima, Yoshiki, Hawkins, Philip N, Solomon, Scott D, Polydefkis, Michael, Dyck, Peter J, Gandhi, Pritesh J, Goyal, Sunita, Chen, Jihong, Strahs, Andrew L, Nochur, Saraswathy V, Sweetser, Marianne T, Garg, Pushkal P, Vaishnaw, Akshay K, Gollob, Jared A, Suhr, Ole B

“…Hereditary transthyretin amyloidosis is caused by the deposition of misfolded transthyretin proteins in peripheral nerves and other tissues. This phase 3 trial…”
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Nonbiopsy Diagnosis of Cardiac Transthyretin Amyloidosis by Gillmore, Julian D, Maurer, Mathew S, Falk, Rodney H, Merlini, Giampaolo, Damy, Thibaud, Dispenzieri, Angela, Wechalekar, Ashutosh D, Berk, John L, Quarta, Candida C, Grogan, Martha, Lachmann, Helen J, Bokhari, Sabahat, Castano, Adam, Dorbala, Sharmila, Johnson, Geoff B, Glaudemans, Andor W.J.M, Rezk, Tamer, Fontana, Marianna, Palladini, Giovanni, Milani, Paolo, Guidalotti, Pierluigi L, Flatman, Katarina, Lane, Thirusha, Vonberg, Frederick W, Whelan, Carol J, Moon, James C, Ruberg, Frederick L, Miller, Edward J, Hutt, David F, Hazenberg, Bouke P, Rapezzi, Claudio, Hawkins, Philip N

“…BACKGROUND—Cardiac transthyretin (ATTR) amyloidosis is a progressive and fatal cardiomyopathy for which several promising therapies are in development. The…”
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Natural History, Quality of Life, and Outcome in Cardiac Transthyretin Amyloidosis by Lane, Thirusha, Fontana, Marianna, Martinez-Naharro, Ana, Quarta, Candida Cristina, Whelan, Carol J, Petrie, Aviva, Rowczenio, Dorota M, Gilbertson, Janet A, Hutt, David F, Rezk, Tamer, Strehina, Svetla G, Caringal-Galima, Joan, Manwani, Richa, Sharpley, Faye A, Wechalekar, Ashutosh D, Lachmann, Helen J, Mahmood, Shameem, Sachchithanantham, Sajitha, Drage, Edmund P.S, Jenner, Harvey D, McDonald, Rosie, Bertolli, Ottavia, Calleja, Alan, Hawkins, Philip N, Gillmore, Julian D

“…BACKGROUND:Transthyretin amyloidosis cardiomyopathy (ATTR-CM) is an increasingly recognized cause of heart failure in older individuals. We sought to…”
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A new staging system for cardiac transthyretin amyloidosis by Gillmore, Julian D, Damy, Thibaud, Fontana, Marianna, Hutchinson, Matthew, Lachmann, Helen J, Martinez-Naharro, Ana, Quarta, Candida C, Rezk, Tamer, Whelan, Carol J, Gonzalez-Lopez, Esther, Lane, Thirusha, Gilbertson, Janet A, Rowczenio, Dorota, Petrie, Aviva, Hawkins, Philip N

“…Abstract Aims Cardiac transthyretin (ATTR) amyloidosis is an increasingly recognized, progressive, and fatal cardiomyopathy, the natural history of which…”
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Diagnostic imaging of cardiac amyloidosis by Martinez-Naharro, Ana, Baksi, A. John, Hawkins, Philip N., Fontana, Marianna

“…Systemic amyloidosis encompasses a debilitating, under-diagnosed but increasingly recognized group of disorders characterized by the extracellular deposition…”
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Noncontrast T1 Mapping for the Diagnosis of Cardiac Amyloidosis by Karamitsos, Theodoros D., MD, PhD, Piechnik, Stefan K., PhD, MScEE, Banypersad, Sanjay M., MBChB, Fontana, Marianna, MD, Ntusi, Ntobeko B., MBChB, Ferreira, Vanessa M., MD, Whelan, Carol J., MD, Myerson, Saul G., MD, Robson, Matthew D., PhD, Hawkins, Philip N., PhD, Neubauer, Stefan, MD, Moon, James C., MD

“…Objectives This study sought to explore the potential role of noncontrast myocardial T1 mapping for detection of cardiac involvement in patients with primary…”
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New Criteria for Response to Treatment in Immunoglobulin Light Chain Amyloidosis Based on Free Light Chain Measurement and Cardiac Biomarkers: Impact on Survival Outcomes by PALLADINI, Giovanni, DISPENZIERI, Angela, DIMOPOULOS, Meletios A, JACCARD, Arnaud, KLERSY, Catherine, MERLINI, Giampaolo, GERTZ, Morie A, KUMAR, Shaji, WECHALEKAR, Ashutosh, HAWKINS, Philip N, SCHÖNLAND, Stefan, HEGENBART, Ute, COMENZO, Raymond, KASTRITIS, Efstathios

“…To identify the criteria for hematologic and cardiac response to treatment in immunoglobulin light chain (AL) amyloidosis based on survival analysis of a large…”
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Expert consensus recommendations to improve diagnosis of ATTR amyloidosis with polyneuropathy by Adams, David, Ando, Yukio, Beirão, João Melo, Coelho, Teresa, Gertz, Morie A., Gillmore, Julian D., Hawkins, Philip N., Lousada, Isabelle, Suhr, Ole B., Merlini, Giampaolo

“…Amyloid transthyretin (ATTR) amyloidosis with polyneuropathy (PN) is a progressive, debilitating, systemic disease wherein transthyretin protein misfolds to…”
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Native T1 and Extracellular Volume in Transthyretin Amyloidosis by Martinez-Naharro, Ana, Kotecha, Tushar, Norrington, Karl, Boldrini, Michele, Rezk, Tamer, Quarta, Candida, Treibel, Thomas A., Whelan, Carol J., Knight, Daniel S., Kellman, Peter, Ruberg, Frederick L., Gillmore, Julian D., Moon, James C., Hawkins, Philip N., Fontana, Marianna

“…This study evaluated the prognostic potential of native myocardial T1 in cardiac transthyretin amyloidosis (ATTR) and compared native T1 with extracellular…”
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Prevalence of Cardiac Amyloidosis in Patients Referred for Transcatheter Aortic Valve Replacement by Scully, Paul R., Treibel, Thomas A., Fontana, Marianna, Lloyd, Guy, Mullen, Michael, Pugliese, Francesca, Hartman, Neil, Hawkins, Philip N., Menezes, Leon J., Moon, James C.

“…Wild-type transthyretin amyloid (wtATTR) affects the heart, causing a restrictive cardiomyopathy-deposits can be found in up to 25% of individuals >85 years of…”
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Prognostic Value of Late Gadolinium Enhancement Cardiovascular Magnetic Resonance in Cardiac Amyloidosis by Fontana, Marianna, Pica, Silvia, Reant, Patricia, Abdel-Gadir, Amna, Treibel, Thomas A, Banypersad, Sanjay M, Maestrini, Viviana, Barcella, William, Rosmini, Stefania, Bulluck, Heerajnarain, Sayed, Rabya H, Patel, Ketna, Mamhood, Shameem, Bucciarelli-Ducci, Chiara, Whelan, Carol J, Herrey, Anna S, Lachmann, Helen J, Wechalekar, Ashutosh D, Manisty, Charlotte H, Schelbert, Eric B, Kellman, Peter, Gillmore, Julian D, Hawkins, Philip N, Moon, James C

“…BACKGROUND—The prognosis and treatment of the 2 main types of cardiac amyloidosis, immunoglobulin light chain (AL) and transthyretin (ATTR) amyloidosis, are…”
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Characteristics and natural history of early-stage cardiac transthyretin amyloidosis by Law, Steven, Bezard, Melanie, Petrie, Aviva, Chacko, Liza, Cohen, Oliver C, Ravichandran, Sriram, Ogunbiyi, Olabisi, Kharoubi, Mounira, Ganeshananthan, Sashiananthan, Ganeshananthan, Sharmananthan, Gilbertson, Janet A, Rowczenio, Dorota, Wechalekar, Ashutosh, Martinez-Naharro, Ana, Lachmann, Helen J, Whelan, Carol J, Hutt, David F, Hawkins, Philip N, Damy, Thibaud, Fontana, Marianna, Gillmore, Julian D

“…Transthyretin amyloid cardiomyopathy (ATTR-CM) is increasingly diagnosed at an early stage of the disease natural history, defined as National Amyloidosis…”
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Therapeutic Clearance of Amyloid by Antibodies to Serum Amyloid P Component by Richards, Duncan B, Cookson, Louise M, Berges, Alienor C, Barton, Sharon V, Lane, Thirusha, Ritter, James M, Fontana, Marianna, Moon, James C, Pinzani, Massimo, Gillmore, Julian D, Hawkins, Philip N, Pepys, Mark B

“…A two-step process, in which circulating levels of amyloid P are reduced and then anti–serum amyloid P antibody is given to activate macrophage clearance…”
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Prevalence and outcome of dual aortic stenosis and cardiac amyloid pathology in patients referred for transcatheter aortic valve implantation by Scully, Paul R, Patel, Kush P, Treibel, Thomas A, Thornton, George D, Hughes, Rebecca K, Chadalavada, Sucharitha, Katsoulis, Michail, Hartman, Neil, Fontana, Marianna, Pugliese, Francesca, Sabharwal, Nikant, Newton, James D, Kelion, Andrew, Ozkor, Muhiddin, Kennon, Simon, Mullen, Michael, Lloyd, Guy, Menezes, Leon J, Hawkins, Philip N, Moon, James C

“…Abstract Aims Cardiac amyloidosis is common in elderly patients with aortic stenosis (AS) referred for transcatheter aortic valve implantation (TAVI). We…”
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Online Registry for Mutations in Hereditary Amyloidosis Including Nomenclature Recommendations by Rowczenio, Dorota M., Noor, Islam, Gillmore, Julian D., Lachmann, Helen J., Whelan, Carol, Hawkins, Philip N., Obici, Laura, Westermark, Per, Grateau, Gilles, Wechalekar, Ashutosh D.

“…ABSTRACT Hereditary systemic amyloidosis comprises a group of rare monogenic diseases inherited in an autosomal dominant fashion. It is associated with…”
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Prevalence and Outcomes of Concomitant Aortic Stenosis and Cardiac Amyloidosis by Nitsche, Christian, Scully, Paul R., Patel, Kush P., Kammerlander, Andreas A., Koschutnik, Matthias, Dona, Carolina, Wollenweber, Tim, Ahmed, Nida, Thornton, George D., Kelion, Andrew D., Sabharwal, Nikant, Newton, James D., Ozkor, Muhiddin, Kennon, Simon, Mullen, Michael, Lloyd, Guy, Fontana, Marianna, Hawkins, Philip N., Pugliese, Francesca, Menezes, Leon J., Moon, James C., Mascherbauer, Julia, Treibel, Thomas A.

“…Older patients with severe aortic stenosis (AS) are increasingly identified as having cardiac amyloidosis (CA). It is unknown whether concomitant AS-CA has…”
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