Search Results - "Hawkins, Julie L"

Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia by Mansour, Mahmoud N, Seddon, Andrew P, Hoth, Lise R, Xia, Donghui, Geoghegan, Kieran F, Griffor, Matthew C, Subashi, Timothy A, Shenolikar, Shirish, Danley, Dennis E, Ammirati, Mark J, McGrath, Katherine M, Culp, Jeffrey S, Hawkins, Julie L, Varghese, Alison H, Qiu, Xiayang, Warren, Laurie C, Cunningham, David, Stutzman-Engwall, Kim J

“…Proprotein convertase subtilisin kexin type 9 (PCSK9) lowers the abundance of surface low-density lipoprotein (LDL) receptor through an undefined mechanism…”
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Pharmacologic inhibition of site 1 protease activity inhibits sterol regulatory element-binding protein processing and reduces lipogenic enzyme gene expression and lipid synthesis in cultured cells and experimental animals by Hawkins, Julie L, Robbins, Michael D, Warren, Laurie C, Xia, Donghui, Petras, Stephen F, Valentine, James J, Varghese, Alison H, Wang, Ing-Kae, Subashi, Timothy A, Shelly, Lorraine D, Hay, Bruce A, Landschulz, Katherine T, Geoghegan, Kieran F, Harwood, Jr, H James

“…Sterol regulatory element-binding proteins (SREBPs) are major transcriptional regulators of cholesterol, fatty acid, and glucose metabolism. Genetic disruption…”
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Aminopyrrolidineamide inhibitors of site-1 protease by Hay, Bruce A., Abrams, Barbara, Zumbrunn, Allice Y., Valentine, James J., Warren, Laurie C., Petras, Stephen F., Shelly, Lorraine D., Xia, Angela, Varghese, Alison H., Hawkins, Julie L., Van Camp, Jennifer A., Robbins, Michael D., Landschulz, Katherine, Harwood, H. James

“…A series of aminopyrrolidineamide inhibitors of sterol regulatory element binding protein site-1 protease was identified. The discovery and efficacy of a…”
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