Search Results - "Hawkins, Bryson"

A Guide to In Silico Drug Design by Chang, Yiqun, Hawkins, Bryson A, Du, Jonathan J, Groundwater, Paul W, Hibbs, David E, Lai, Felcia

“…The drug discovery process is a rocky path that is full of challenges, with the result that very few candidates progress from hit compound to a commercially…”
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Can we Predict Drug Excretion into Saliva? A Systematic Review and Analysis of Physicochemical Properties by Nguyen, Thi A., Chen, Ricky H., Hawkins, Bryson A., Hibbs, David E., Kim, Hannah Y., Wheate, Nial J., Groundwater, Paul W., Stocker, Sophie L., Alffenaar, Jan-Willem C.

“…Background and Objectives Saliva is a patient-friendly matrix for therapeutic drug monitoring (TDM) but is infrequently used in routine care. This is due to…”
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Discovery of 2′,6-Bis(4-hydroxybenzyl)-2-acetylcyclohexanone, a Novel FtsZ Inhibitor by Lin, Hsuan-Yu J, Battaje, Rachana Rao, Tan, Jinlong, Doddareddy, Munikumar, Dhaked, Hemendra Pal Singh, Srivastava, Shalini, Hawkins, Bryson A, Al-Shdifat, Laith Mohammad Hilal, Hibbs, David E, Panda, Dulal, Groundwater, Paul W

“…Multi-drug resistance is increasing in the pathogenic bacterium S. pneumoniae, which is mainly responsible for meningitis and community-acquired pneumonia…”
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Understanding Hygroscopicity of Theophylline via a Novel Cocrystal Polymorph: A Charge Density Study by Stanton, Stephen A, Du, Jonathan J, Lai, Felcia, Stanton, Gyte, Hawkins, Bryson A, Ong, Jennifer A, Groundwater, Paul W, Platts, James A, Hibbs, David E

“…The charge density distribution in a novel cocrystal (1) complex of 1,3-dimethylxanthine (theophylline) and propanedioic acid (malonic acid) has been…”
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Exploring the Solubility of the Carbamazepine–Saccharin Cocrystal: A Charge Density Study by Du, Jonathan J, Stanton, Stephen A, Fakih, Slaiman, Hawkins, Bryson A, Williams, Peter A, Groundwater, Paul W, Overgaard, Jacob, Platts, James A, Hibbs, David E

“…Carbamazepine (CBZ) is used in the treatment of multiple neurological conditions. Although efficacious, its potential has been limited by its poor solubility,…”
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Small molecule produced by Photorhabdus interferes with ubiquinone biosynthesis in Gram-negative bacteria by Bargabos, Rachel, Iinishi, Akira, Hawkins, Bryson, Privalsky, Thomas, Pitt, Norman, Son, Sangkeun, Corsetti, Rachel, Gates, Michael F, Miller, Ryan D, Lewis, Kim

“…We report the identification of 3,6-dihydroxy-1,2-benzisoxazole (DHB) in a screen of and , whose symbiotic relationship with eukaryotic nematodes favors…”
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An experimental and theoretical charge density study of theophylline and malonic acid cocrystallization by Hawkins, Bryson A, Du, Jonathan J, Lai, Felcia, Stanton, Stephen A, Williams, Peter A, Groundwater, Paul W, Platts, James A, Overgaard, Jacob, Hibbs, David E

“…The pharmaceutical agent theophylline (THEO) is primarily used as a bronchodilator and is commercially available in both tablet and liquid dosage forms. THEO…”
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Analyzing Hydration Differences in Cocrystal Polymorphs: High-Resolution X‑ray Investigation of Caffeine–Glutaric Acid Cocrystals by Hawkins, Bryson A, Han, Jaeyeon, Du, Jonathan J, Lai, Felcia, Stanton, Stephen A, Divakarla, Shravan S, Groundwater, Paul W, Platts, James A, Hibbs, David E

“…Two polymorphic forms of caffeine (CAF)–glutaric acid (GLU) cocrystals have been studied via high-resolution X-ray crystallography and Bader’s quantum theory…”
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The role of adjuvants in overcoming antibacterial resistance due to enzymatic drug modification by El-Khoury, Christy, Mansour, Elissar, Yuliandra, Yori, Lai, Felcia, Hawkins, Bryson A, Du, Jonathan J, Sundberg, Eric J, Sluis-Cremer, Nicolas, Hibbs, David E, Groundwater, Paul W

“…Antibacterial resistance is a prominent issue with monotherapy often leading to treatment failure in serious infections. Many mechanisms can lead to…”
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Fluorinated tetrapodal anion transporters by Gilchrist, Alexander M., Wu, Xin, Hawkins, Bryson A., Hibbs, David E., Gale, Philip A.

“…Synthetic anion transporters show potential in treating life-threatening diseases like cystic fibrosis and cancer. However, with increasingly complex…”
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New compounds based on a benzimidazole nucleus: synthesis, characterization and cytotoxic activity against breast and colon cancer cell lines by Akkoç, Senem, Kayser, Veysel, İlhan, İlhan Özer, Hibbs, David E., Gök, Yetkin, Williams, Peter A., Hawkins, Bryson, Lai, Felcia

“…Benzimidazolium salts and their Pyridine Enhanced Precatalyst Preparation Stabilization and Initiation (PEPPSI) palladium N-heterocyclic carbene (Pd-NHC) based…”
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Safety and efficacy comparisons of intravenous trastuzumab biosimilars to the reference product medicine in treatment‐naïve and switch‐over patients with breast cancer: a systematic and meta‐analysis by Song, Nina K., Musa, Hala, Soriano, Michael, Batger, Mellissa, Hawkins, Bryson, Ramzan, Iqbal, Hibbs, David E., Ong, Jennifer

“…Aim To compare the efficacy and safety of trastuzumab biosimilars to reference trastuzumab in patients with breast cancer. Trastuzumab, a biologic…”
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Safety and efficacy comparisons of rituximab biosimilars to the reference product in patients with cancer: a systematic meta‐analysis review by Song, Nina K., Musa, Hala, Soriano, Michael, Batger, Mellissa, Hawkins, Bryson, Ramzan, Iqbal, Hibbs, David E., Ong, Jennifer A.

“…Aim To compare the efficacy and safety of rituximab biosimilars to reference rituximab in patients with cancer. Data Sources A systematic review and…”
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Identification of agents targeting FtsZ assembly by Panda, Dulal, Bhattacharya, Dipanwita, Gao, Quanqing Helen, Oza, Pratik M, Lin, H-Y Jennifer, Hawkins, Bryson, Hibbs, David E, Groundwater, Paul W

“…Filamenting temperature-sensitive mutant Z (FtsZ), an essential cell division protein in bacteria, has recently emerged as an important and exploitable…”
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"Discovering" Snell's Law by Hobbs, E. D, Hawkins, Bryson

“…Describes a science activity which allows secondary level students to discover the law of refraction. (SL)…”
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