Search Results - "Hawkins, Brian T"

Three-dimensional (3D) tetra-culture brain on chip platform for organophosphate toxicity screening by Koo, Youngmi, Hawkins, Brian T., Yun, Yeoheung

“…Organophosphate-based compounds (OPs) represent a significant threat to warfighters (nerve agents) and civilian populations (pesticides). There is a pressing…”
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The Blood-Brain Barrier/Neurovascular Unit in Health and Disease by Hawkins, Brian T, Davis, Thomas P

“…The blood-brain barrier (BBB) is the regulated interface between the peripheral circulation and the central nervous system (CNS). Although originally observed…”
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β1-integrin–matrix interactions modulate cerebral microvessel endothelial cell tight junction expression and permeability by Izawa, Yoshikane, Gu, Yu-Huan, Osada, Takashi, Kanazawa, Masato, Hawkins, Brian T, Koziol, James A, Papayannopoulou, Thalia, Spatz, Maria, del Zoppo, Gregory J

“…Acutely following focal cerebral ischemia disruption of the microvessel blood–brain barrier allows transit of plasma proteins into the neuropil as edema…”
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Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain by Cannon, Ronald E, Peart, John C, Hawkins, Brian T, Campos, Christopher R, Miller, David S

“…P-glycoprotein, an ATP-driven drug efflux pump, is a major obstacle to the delivery of small-molecule drugs across the blood-brain barrier and into the CNS…”
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Aryl hydrocarbon receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier by Wang, Xueqian, Hawkins, Brian T, Miller, David S

“…Many widespread and persistent organic pollutants, e.g., 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), activate the aryl hydrocarbon receptor (AhR), causing it…”
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Three-dimensional culture conditions differentially affect astrocyte modulation of brain endothelial barrier function in response to transforming growth factor β1 by Hawkins, Brian T, Grego, Sonia, Sellgren, Katelyn L

“…Abstract Blood–brain barrier (BBB) function is regulated by dynamic interactions among cell types within the neurovascular unit, including astrocytes and…”
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Inducing Deep Sweeps and Vortex Ejections on Patterned Membrane Surfaces to Mitigate Surface Fouling by Young, August H, Hotz, Nico, Hawkins, Brian T, Kabala, Zbigniew J

“…Patterned membrane surfaces offer a hydrodynamic approach to mitigating concentration polarization and subsequent surface fouling. However, when subjected to…”
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A hands-free stool sampling system for monitoring intestinal health and disease by Grego, Sonia, Welling, Claire M., Miller, Graham H., Coggan, Peter F., Sellgren, Katelyn L., Hawkins, Brian T., Ginsburg, Geoffrey S., Ruiz, Jose R., Fisher, Deborah A., Stoner, Brian R.

“…Analysis of stool offers simple, non-invasive monitoring for many gastrointestinal (GI) diseases and access to the gut microbiome, however adherence to stool…”
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Enhanced H2O2 Production at Reductive Potentials from Oxidized Boron-Doped Ultrananocrystalline Diamond Electrodes by Thostenson, James O, Ngaboyamahina, Edgard, Sellgren, Katelyn L, Hawkins, Brian T, Piascik, Jeffrey R, Klem, Ethan J. D, Parker, Charles B, Deshusses, Marc A, Stoner, Brian R, Glass, Jeffrey T

“…This work investigates the surface chemistry of H2O2 generation on a boron-doped ultrananocrystalline diamond (BD-UNCD) electrode. It is motivated by the need…”
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Disruption of dystroglycan–laminin interactions modulates water uptake by astrocytes by Hawkins, Brian T, Gu, Yu-Huan, Izawa, Yoshikane, del Zoppo, Gregory J

“…Abstract Cerebral edema is a serious complication of ischemic brain injury. Cerebral edema includes accumulation of extracellular fluid due to leakage of the…”
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Rapid Loss of Blood–Brain Barrier P-Glycoprotein Activity through Transporter Internalization Demonstrated Using a Novel in Situ Proteolysis Protection Assay by Hawkins, Brian T, Rigor, Robert R, Miller, David S

“…Blood–brain barrier (BBB) P-glycoprotein activity is rapidly reduced by vascular endothelial growth factor (VEGF) acting via Src and by tumor necrosis factor-α…”
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Nicotine increases in vivo blood–brain barrier permeability and alters cerebral microvascular tight junction protein distribution by Hawkins, Brian T., Abbruscato, Thomas J., Egleton, Richard D., Brown, Rachel C., Huber, Jason D., Campos, Christopher R., Davis, Thomas P.

“…The blood–brain barrier (BBB) is critical to the health of the central nervous system. The BBB is formed primarily by the presence of tight junctions (TJ)…”
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Chronic inflammatory pain leads to increased blood-brain barrier permeability and tight junction protein alterations by Brooks, Tracy A, Hawkins, Brian T, Huber, Jason D, Egleton, Richard D, Davis, Thomas P

“…The blood-brain barrier (BBB) maintains brain homeostasis by limiting entry of substances to the central nervous system through interaction of transmembrane…”
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Activating PKC-β1 at the blood—brain barrier reverses induction of P-glycoprotein activity by dioxin and restores drug delivery to the CNS by Wang, Xueqian, Hawkins, Brian T, Miller, David S

“…Upregulation of blood-brain barrier (BBB) P-glycoprotein expression causes central nervous system (CNS) pharmacoresistance. However, activation of BBB protein…”
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Decreased blood–brain barrier permeability to fluorescein in streptozotocin-treated rats by Hawkins, Brian T., Ocheltree, Scott M., Norwood, Kristi M., Egleton, Richard D.

“…Investigations of the blood–brain barrier (BBB) in diabetes have yielded contradictory results. It is possible that diabetes differentially affects…”
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Modulation of cerebral microvascular permeability by endothelial nicotinic acetylcholine receptors by Hawkins, Brian T, Egleton, Richard D, Davis, Thomas P

“…Nicotine increases the permeability of the blood-brain barrier in vivo. This implies a possible role for nicotinic acetylcholine receptors in the regulation of…”
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Non-biological methods for phosphorus and nitrogen removal from wastewater: A gap analysis of reinvented-toilet technologies with respect to ISO 30500 by Trotochaud, Lena, Hawkins, Brian T, Stoner, Brian R

“…The aims of the Reinvent the Toilet Challenge (RTTC) include creation of an off-the-grid sanitation system with operating costs of less than US$0.05 per user…”
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Nicotine and cotinine modulate cerebral microvascular permeability and protein expression of ZO-1 through nicotinic acetylcholine receptors expressed on brain endothelial cells by Abbruscato, Thomas J, Lopez, Steve P, Mark, Karen S, Hawkins, Brian T, Davis, Thomas P

“…The blood-brain barrier (BBB) adapts to a variety of pathological processes. Little is known about the effects of nicotine exposure on BBB function and the…”
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Comparative changes in the blood-brain barrier and cerebral infarction of SHR and WKY rats by Hom, Sharon, Fleegal, Melissa A, Egleton, Richard D, Campos, Christopher R, Hawkins, Brian T, Davis, Thomas P

“…Hypertension is involved in the exacerbation of stroke. It is unclear how blood-brain barrier (BBB) tight-junction (TJ) and ion transporter proteins critical…”
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Improving energy efficiency of electrochemical blackwater disinfection through sequential reduction of suspended solids and chemical oxygen demand by Hawkins, Brian T., Rogers, Tate W., Davey, Christopher J., Stoner, Mikayla H., McAdam, Ewan J., Stoner, Brian R.

“…Onsite reuse of blackwater requires removal of considerable amounts of suspended solids and organic material in addition to inactivation of pathogens…”
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