Search Results - "Hawkins, Alastair R."

Glycan complexity dictates microbial resource allocation in the large intestine by Rogowski, Artur, Briggs, Jonathon A., Mortimer, Jennifer C., Tryfona, Theodora, Terrapon, Nicolas, Lowe, Elisabeth C., Baslé, Arnaud, Morland, Carl, Day, Alison M., Zheng, Hongjun, Rogers, Theresa E., Thompson, Paul, Hawkins, Alastair R., Yadav, Madhav P., Henrissat, Bernard, Martens, Eric C., Dupree, Paul, Gilbert, Harry J., Bolam, David N.

“…The structure of the human gut microbiota is controlled primarily through the degradation of complex dietary carbohydrates, but the extent to which…”
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Quinate-based ligands for irreversible inactivation of the bacterial virulence factor DHQ1 enzyme-A molecular insight by Rodríguez, Ángela, Maneiro, María, Lence, Emilio, Otero, José M, van Raaij, Mark J, Thompson, Paul, Hawkins, Alastair R, González-Bello, Concepción

“…Irreversible inhibition of the enzyme type I dehydroquinase (DHQ1), a promising target for anti-virulence drug development, has been explored by enhancing the…”
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Mechanistic insight into the reaction catalysed by bacterial type II dehydroquinases by Coderch, Claire, Lence, Emilio, Peón, Antonio, Lamb, Heather, Hawkins, Alastair R, Gago, Federico, González-Bello, Concepción

“…DHQ2 (type II dehydroquinase), which is an essential enzyme in Helicobacter pylori and Mycobacterium tuberculosis and does not have any counterpart in humans,…”
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Insights into substrate binding and catalysis in bacterial type I dehydroquinase by Maneiro, María, Peón, Antonio, Lence, Emilio, Otero, José M, Van Raaij, Mark J, Thompson, Paul, Hawkins, Alastair R, González-Bello, Concepción

“…Structural, biochemical and computational studies to study substrate binding and the role of the conserved residues of the DHQ1 (type I dehydroquinase) enzyme…”
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GTP Cyclohydrolase II Structure and Mechanism by Ren, Jingshan, Kotaka, Masayo, Lockyer, Michael, Lamb, Heather K., Hawkins, Alastair R., Stammers, David K.

“…GTP cyclohydrolase II converts GTP to 2,5-diamino-6-β-ribosyl-4(3H)-pyrimidinone 5′-phosphate, formate and pyrophosphate, the first step in riboflavin…”
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The Affinity of a Major Ca2+ Binding Site on GRP78 Is Differentially Enhanced by ADP and ATP by Lamb, Heather K., Mee, Christopher, Xu, Weiming, Liu, Lizhi, Blond, Sylvie, Cooper, Alan, Charles, Ian G., Hawkins, Alastair R.

“…GRP78 is a major protein regulated by the mammalian endoplasmic reticulum stress response, and up-regulation has been shown to be important in protecting cells…”
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2-Substituted-3-Dehydroquinic Acids as Potent Competitive Inhibitors of Type II Dehydroquinase by Prazeres, Verónica F. V., Castedo, Luis, Lamb, Heather, Hawkins, Alastair R., González-Bello, Concepción

“…Potential antibiotics: The substitution of either the pro‐R or pro‐S hydrogen of the 3‐dehydroquinic acid, the natural substrate of type II dehydroquinase, by…”
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Structure-Based Design, Synthesis, and Biological Evaluation of Inhibitors of Mycobacterium tuberculosis Type II Dehydroquinase by SáNCHEZ-SIXTO, Cristina, PRAZERES, Verónica F. V., CASTEDO, Luis, LAMB, Heather, HAWKINS, Alastair R., GONZáLEZ-BELLO, Concepción

“…The syntheses by Suzuki cross-coupling of 12 5-aryl analogues of the known inhibitor (1R,3R,4R)-1,3,4-trihydroxycyclohex-5-en-1-carboxylic acid are reported…”
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The Negative Transcriptional Regulator NmrA Discriminates between Oxidized and Reduced Dinucleotides by Lamb, Heather K., Leslie, Kris, Dodds, Anna L., Nutley, Margaret, Cooper, Alan, Johnson, Christopher, Thompson, Paul, Stammers, David K., Hawkins, Alastair R.

“…NmrA, a transcription repressor involved in the regulation of nitrogen metabolism in Aspergillus nidulans,is a member of the short-chain dehydrogenase…”
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Crystal Structure of SANOS, a Bacterial Nitric Oxide Synthase Oxygenase Protein from Staphylococcus aureus by Bird, Louise E, Ren, Jingshan, Zhang, Jiancheng, Foxwell, Neale, Hawkins, Alastair R, Charles, Ian G, Stammers, David K

“…Prokaryotic genes related to the oxygenase domain of mammalian nitric oxide synthases (NOSs) have recently been identified. Although they catalyze the same…”
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Competitive Inhibitors of Helicobacter pylori Type II Dehydroquinase: Synthesis, Biological Evaluation, and NMR Studies by Sánchez-Sixto, Cristina, Prazeres, Verónica F. V., Castedo, Luis, Suh, Se Won, Lamb, Heather, Hawkins, Alastair R., Cañada, Francisco Javier, Jiménez-Barbero, Jesús, González-Bello, Concepción

“…Several 3‐heteroaryl analogs of the known dehydroquinase inhibitor (1R,4R,5R)‐1,4,5‐trihydroxy‐2‐cyclohexene‐1‐carboxylic acid (4) were synthesized and tested…”
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Structure of dehydroquinate synthase reveals an active site capable of multistep catalysis by Brown, Katherine A, Carpenter, Elisabeth P, Hawkins, Alastair R, Frost, John W

“…Dehydroquinate synthase (DHQS) has long been regarded as a catalytic marvel because of its ability to perform several consecutive chemical reactions in one…”
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Self‐Immolation of a Bacterial Dehydratase Enzyme by its Epoxide Product by Lence, Emilio, Maneiro, María, Sanz‐Gaitero, Marta, Raaij, Mark J., Thompson, Paul, Hawkins, Alastair R., González‐Bello, Concepción

“…Disabling the bacterial capacity to cause infection is an innovative approach that has attracted significant attention to fight against superbugs. A relevant…”
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Crystal structure of NucB, a biofilm-degrading endonuclease by Baslé, Arnaud, Hewitt, Lorraine, Koh, Alan, Lamb, Heather K, Thompson, Paul, Burgess, J Grant, Hall, Michael J, Hawkins, Alastair R, Murray, Heath, Lewis, Richard J

“…Abstract Bacterial biofilms are a complex architecture of cells that grow on moist interfaces, and are held together by a molecular glue of extracellular…”
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Mycobacterium tuberculosis Shikimate Kinase Inhibitors: Design and Simulation Studies of the Catalytic Turnover by Blanco, Beatriz, Prado, Verónica, Lence, Emilio, Otero, José M, Garcia-Doval, Carmela, van Raaij, Mark J, Llamas-Saiz, Antonio L, Lamb, Heather, Hawkins, Alastair R, González-Bello, Concepción

“…Shikimate kinase (SK) is an essential enzyme in several pathogenic bacteria and does not have any counterpart in human cells, thus making it an attractive…”
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Matriptase Induction of Metalloproteinase‐Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms by Wilkinson, David J., Habgood, Angela, Lamb, Heather K., Thompson, Paul, Hawkins, Alastair R., Désilets, Antoine, Leduc, Richard, Steinmetzer, Torsten, Hammami, Maya, Lee, Melody S., Craik, Charles S., Watson, Sharon, Lin, Hua, Milner, Jennifer M., Rowan, Andrew D.

“…Objective To assess the ability of matriptase, a type II transmembrane serine proteinase, to promote aggrecan loss from the cartilage of patients with…”
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Nanomolar Competitive Inhibitors of Mycobacterium tuberculosis and Streptomyces coelicolor Type II Dehydroquinase by Prazeres, Verónica F. V., Sánchez-Sixto, Cristina, Castedo, Luis, Lamb, Heather, Hawkins, Alastair R., Riboldi-Tunnicliffe, Alan, Coggins, John R., Lapthorn, Adrian J., González-Bello, Concepción

“…Isomeric nitrophenyl and heterocyclic analogues of the known inhibitor (1S,3R,4R)‐1,3,4‐trihydroxy‐5‐cyclohexene‐1‐carboxylic acid have been synthesized and…”
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Freezing the Dynamic Gap for Selectivity: Motion-Based Design of Inhibitors of the Shikimate Kinase Enzyme by Prado, Verónica, Lence, Emilio, Thompson, Paul, Hawkins, Alastair R., González-Bello, Concepción

“…Shikimate kinase (SK), the fifth enzyme of the aromatic amino acid biosynthesis, is a recognized target for antibiotic drug discovery. The potential of the…”
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Frontispiece: Freezing the Dynamic Gap for Selectivity: Motion-Based Design of Inhibitors of the Shikimate Kinase Enzyme by Prado, Verónica, Lence, Emilio, Thompson, Paul, Hawkins, Alastair R., González-Bello, Concepción

“…Inhibitors Enzymes are “dynamic” systems that are able to adopt diverse conformations during catalysis—an open conformation (OFF) for product release and a…”
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Targeting the Motion of Shikimate Kinase: Development of Competitive Inhibitors that Stabilize an Inactive Open Conformation of the Enzyme by Prado, Verónica, Lence, Emilio, Maneiro, María, Vázquez-Ucha, Juan C, Beceiro, Alejandro, Thompson, Paul, Hawkins, Alastair R, González-Bello, Concepción

“…The large conformational changes observed by Molecular Dynamics simulation studies on the product release in the LID and shikimic acid binding (SB) domains of…”
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