Search Results - "Hawinkels, Lukas J.A.C"

Clinical evidence for a protective role of lipocalin-2 against MMP-9 autodegradation and the impact for gastric cancer by Kubben, Frank J.G.M, Sier, Cornelis F.M, Hawinkels, Lukas J.A.C, Tschesche, Harald, van Duijn, Wim, Zuidwijk, Kim, van der Reijden, Johan J, Hanemaaijer, Roeland, Griffioen, Gerrit, Lamers, Cornelis B.H.W, Verspaget, Hein W

“…Abstract Recently, complexes of matrix metalloproteinase matrix metalloproteinase-9 (MMP-9) with lipocalin-2 (neutrophil gelatinase-associated lipocalin) were…”
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The adaptive immune system promotes initiation of prostate carcinogenesis in a human c-Myc transgenic mouse model by Melis, Monique H M, Nevedomskaya, Ekaterina, van Burgsteden, Johan, Cioni, Bianca, van Zeeburg, Hester J T, Song, Ji-Ying, Zevenhoven, John, Hawinkels, Lukas J A C, de Visser, Karin E, Bergman, Andries M

“…Increasing evidence from epidemiological and pathological studies suggests a role of the immune system in the initiation and progression of multiple cancers,…”
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Translating complexity and heterogeneity of pancreatic tumor: 3D in vitro to in vivo models by Heinrich, Marcel A., Mostafa, Ahmed M.R.H., Morton, Jennifer P., Hawinkels, Lukas J.A.C., Prakash, Jai

“…[Display omitted] Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive type of cancer with an overall survival rate of less than 7–8%,…”
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Endoglin Expression on Cancer-Associated Fibroblasts Regulates Invasion and Stimulates Colorectal Cancer Metastasis by Paauwe, Madelon, Schoonderwoerd, Mark J A, Helderman, Roxan F C P, Harryvan, Tom J, Groenewoud, Arwin, van Pelt, Gabi W, Bor, Rosalie, Hemmer, Danielle M, Versteeg, Henri H, Snaar-Jagalska, B Ewa, Theuer, Charles P, Hardwick, James C H, Sier, Cornelis F M, Ten Dijke, Peter, Hawinkels, Lukas J A C

“…Cancer-associated fibroblasts (CAF) are a major component of the colorectal cancer tumor microenvironment. CAFs play an important role in tumor progression and…”
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Endoglin Targeting: Lessons Learned and Questions That Remain by Liu, Yingmiao, Paauwe, Madelon, Nixon, Andrew B, Hawinkels, Lukas J A C

“…Approximately 30 years ago, endoglin was identified as a transforming growth factor (TGF)-β coreceptor with a crucial role in developmental biology and tumor…”
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Matrix Metalloproteinase-14 (MTi-MMP)-Mediated Endoglin Shedding Inhibits Tumor Angiogenesis by HAWINKELS, Lukas J. A. C, KUIPER, Patricia, WIERCINSKA, Eliza, VERSPAGET, Hein W, ZHEN LIU, PARDALI, Evangelia, SIE, Cornelis F. M, TEN DIJKE, Peter

“…Endoglin is a transforming growth factor-beta coreceptor with a crucial role in angiogenesis. A soluble form of endoglin is present in the circulation, but the…”
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The ABCs of Antigen Presentation by Stromal Non-Professional Antigen-Presenting Cells by Harryvan, Tom J, de Lange, Sabine, Hawinkels, Lukas J A C, Verdegaal, Els M E

“…Professional antigen-presenting cells (APCs), such as dendritic cells and macrophages, are known for their ability to present exogenous antigens to T cells…”
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Extracellular BMP Antagonists, Multifaceted Orchestrators in the Tumor and Its Microenvironment by Ouahoud, Sarah, Hardwick, James C H, Hawinkels, Lukas J A C

“…The bone morphogenetic proteins (BMPs), a subgroup of the transforming growth factor-β (TGF-β) superfamily, are involved in multiple biological processes such…”
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Activin Receptor-like Kinase 1 Ligand Trap Reduces Microvascular Density and Improves Chemotherapy Efficiency to Various Solid Tumors by Hawinkels, Lukas J A C, de Vinuesa, Amaya Garcia, Paauwe, Madelon, Kruithof-de Julio, Marianna, Wiercinska, Eliza, Pardali, Evangelia, Mezzanotte, Laura, Keereweer, Stijn, Braumuller, Tanya M, Heijkants, Renier C, Jonkers, Jos, Löwik, Clemens W, Goumans, Marie-José, ten Hagen, Timo L, ten Dijke, Peter

“…Antiangiogenic therapy, mostly targeting VEGF, has been applied in cancer patients for the last decade. However, resistance to anti-VEGF therapy and/or no…”
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Bidirectional tumor/stroma crosstalk promotes metastasis in mesenchymal colorectal cancer by Ouahoud, Sarah, Voorneveld, Philip W., van der Burg, Lennart R. A., de Jonge-Muller, Eveline S. M., Schoonderwoerd, Mark J. A., Paauwe, Madelon, de Vos, Thijs, de Wit, Sophie, van Pelt, Gabi W., Mesker, Wilma E., Hawinkels, Lukas J.A.C., Hardwick, James C. H.

“…Patients with the mesenchymal subtype colorectal cancer (CRC) have a poor prognosis, in particular patients with stroma-rich tumors and aberrant SMAD4…”
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Mesenchymal stromal cells prevent progression of liver fibrosis in a novel zebrafish embryo model by van der Helm, Danny, Groenewoud, Arwin, de Jonge-Muller, Eveline S. M., Barnhoorn, Marieke. C., Schoonderwoerd, Mark J. A., Coenraad, Minneke J., Hawinkels, Lukas J. A. C., Snaar-Jagalska, B. Ewa, van Hoek, Bart, Verspaget, Hein W.

“…Chronic liver damage leads to the onset of fibrogenesis. Rodent models for liver fibrosis have been widely used, but are less suitable for screening purposes…”
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Prostaglandin F2α-induced Prostate Transmembrane Protein, Androgen Induced 1 mediates ovarian cancer progression increasing epithelial plasticity by Jiménez-Segovia, Alba, Mota, Alba, Rojo-Sebastián, Alejandro, Barrocal, Beatriz, Rynne-Vidal, Angela, García-Bermejo, María-Laura, Gómez-Bris, Raquel, Hawinkels, Lukas J.A.C., Sandoval, Pilar, Garcia-Escudero, Ramon, López-Cabrera, Manuel, Moreno-Bueno, Gema, Fresno, Manuel, Stamatakis, Konstantinos

“…The role of prostaglandin (PG) F2α has been scarcely studied in cancer. We have identified a new function for PGF2α in ovarian cancer, stimulating the…”
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VEGF release by MMP-9 mediated heparan sulphate cleavage induces colorectal cancer angiogenesis by Hawinkels, Lukas J.A.C, Zuidwijk, Kim, Verspaget, Hein W, de Jonge-Muller, Eveline S.M, Duijn, Wim van, Ferreira, Valérie, Fontijn, Ruud D, David, Guido, Hommes, Daniel W, Lamers, Cornelis B.H.W, Sier, Cornelis F.M

“…Abstract Angiogenesis is crucial for the progression of colorectal carcinomas in which the bioavailability of Vascular Endothelial Growth Factor (VEGF) plays a…”
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Corrigendum to “Prostaglandin F2α-induced prostate transmembrane protein, androgen induced 1 mediates ovarian cancer progression increasing epithelial plasticity” [Neoplasia 21 (2019) 1073–1084] by Jiménez-Segovia, Alba, Mota, Alba, Rojo-Sebastián, Alejandro, Barrocal, Beatriz, Rynne-Vidal, Angela, García-Bermejo, María-Laura, Gómez-Bris, Raquel, Hawinkels, Lukas J.A.C., Sandoval, Pilar, Garcia-Escudero, Ramon, López-Cabrera, Manuel, Moreno-Bueno, Gema, Fresno, Manuel, Stamatakis, Konstantinos

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Targeting Endoglin Expressing Cells in the Tumor Microenvironment Does Not Inhibit Tumor Growth in a Pancreatic Cancer Mouse Model by Schoonderwoerd, Mark J A, Hakuno, Sarah K, Sassen, Martijn, Kuhlemaijer, Eleonore B, Paauwe, Madelon, Slingerland, Marije, Fransen, Marieke F, Hawinkels, Lukas J A C

“…Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal forms of cancer and is known to have low immunogenicity and an immunosuppressive…”
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Local administration of mesenchymal stromal cells is safe and modulates the immune compartment in ulcerative proctitis by Ouboter, Laura F, Barnhoorn, Marieke C, Verspaget, Hein W, Plug, Leonie, Pool, Emma S, Szuhai, Karoly, Hawinkels, Lukas Jac, van Pel, Melissa, Zwaginga, Jaap Jan, Roelen, Dave, Koning, Frits, Pascutti, M Fernanda, van der Meulen-de Jong, Andrea E

“…BACKGROUNDDue to their immunoregulatory and tissue regenerative features, mesenchymal stromal cells (MSCs) are a promising novel tool for the management of…”
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Prognostic value and clinicopathologic characteristics of L1 cell adhesion molecule (L1CAM) in a large series of vulvar squamous cell carcinomas by Trietsch, Marjolijn D, Oonk, Maaike H M, Hawinkels, Lukas J A C, Bor, Rosalie, van Eendenburg, Jaap D H, Ivanova, Zina, Peters, Alexander A W, Nijman, Hans W, Gaarenstroom, Katja N, Bosse, Tjalling

“…Vulvar cancer treatment is mostly curative, but also has high morbidity rates. In a search for markers that can identify patients at risk of metastases, we…”
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5-Aminosalicylic acid inhibits TGF-β1 signalling in colorectal cancer cells by Koelink, Pim J, Hawinkels, Lukas J.A.C, Wiercinska, Eliza, Sier, Cornelis F.M, Dijke, Peter ten, Lamers, Cornelis B.H.W, Hommes, Daan W, Verspaget, Hein W

“…Abstract The transforming growth factor-β (TGF-β) pathway is an important pathway in the initiation and progression of colorectal cancer. We aimed to determine…”
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Multimodality Imaging Reveals a Gradual Increase in Matrix Metalloproteinase Activity at Aneurysmal Lesions in Live Fibulin-4 Mice by KAIJZEL, Eric L, VAN HEIJNINGEN, Paula M, HAWINKELS, Lukas J. A. C, BERNSEN, Monique R, LÖWIK, Clemens W. G. M, ESSERS, Jeroen, WIELOPOLSKI, Piotr A, VERMEIJ, Marcel, KONING, Gerben A, VAN CAPPELLEN, Wiggert A, QUE, Ivo, CHAN, Alan, DIJKSTRA, Jouke, RAMNATH, Natasja W. M

“…We imaged the protease activity of matrix metalloproteinases (MMPs) upregulated during aneurysm formation, using protease-activatable near-infrared…”
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Endoglin: Beyond the Endothelium by Schoonderwoerd, Mark J.A., Goumans, Marie-Jose T.H., Hawinkels, Lukas J.A.C.

“…Keywords: endoglin; CD105 TGF-β; BMP9; ALK-1; TRC105; tumor microenvironment…”
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