Search Results - "Hawerkamp, Heike C."

Tofacitinib downregulates antiviral immune defence in keratinocytes and reduces T cell activation by Hawerkamp, Heike C, Domdey, Alina, Radau, Lisa, Sewerin, Philipp, Oláh, Péter, Homey, Bernhard, Meller, Stephan

“…Abstract Background Tofacitinib is a novel Janus kinase (JAK) inhibitor approved for the treatment of rheumatoid arthritis, psoriatic arthritis, and ulcerative…”
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von Willebrand factor links primary hemostasis to innate immunity by Drakeford, Clive, Aguila, Sonia, Roche, Fiona, Hokamp, Karsten, Fazavana, Judicael, Cervantes, Mariana P., Curtis, Annie M., Hawerkamp, Heike C., Dhami, Sukhraj Pal Singh, Charles-Messance, Hugo, Hackett, Emer E., Chion, Alain, Ward, Soracha, Ahmad, Azaz, Schoen, Ingmar, Breen, Eamon, Keane, Joe, Murphy, Ross, Preston, Roger J. S., O’Sullivan, Jamie M., Sheedy, Frederick J., Fallon, Padraic, O’Donnell, James S.

“…The plasma multimeric glycoprotein von Willebrand factor (VWF) plays a critical role in primary hemostasis by tethering platelets to exposed collagen at sites…”
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Characterisation of the pro-inflammatory cytokine signature in severe COVID-19 by Hawerkamp, Heike C, Dyer, Adam H, Patil, Neha D, McElheron, Matt, O'Dowd, Niamh, O'Doherty, Laura, Mhaonaigh, Aisling Ui, George, Angel M, O'Halloran, Aisling M, Reddy, Conor, Kenny, Rose Anne, Little, Mark A, Martin-Loeches, Ignacio, Bergin, Colm, Kennelly, Sean P, Donnelly, Seamas C, Bourke, Nollaig M, Long, Aideen, Sui, Jacklyn, Doherty, Derek G, Conlon, Niall, Cheallaigh, Cliona Ni, Fallon, Padraic G

“…Clinical outcomes from infection with SARS-CoV-2, the cause of the COVID-19 pandemic, are remarkably variable ranging from asymptomatic infection to severe…”
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Type I IFNs link skin-associated dysbiotic commensal bacteria to pathogenic inflammation and angiogenesis in rosacea by Mylonas, Alessio, Hawerkamp, Heike C, Wang, Yichen, Chen, Jiaqi, Messina, Francesco, Demaria, Olivier, Meller, Stephan, Homey, Bernhard, Di Domizio, Jeremy, Mazzolai, Lucia, Hovnanian, Alain, Gilliet, Michel, Conrad, Curdin

“…Rosacea is a common chronic inflammatory skin disease with a fluctuating course of excessive inflammation and apparent neovascularization. Microbial dysbiosis…”
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Expelliarmus helminthus! Harry Helminth and the Goblet of Alarmins by Hawerkamp, Heike C, Fallon, Padraic G

“…Epithelial cells (tuft and goblet cells) interact with immune cells on the "inside" while secreting effector molecules into the topological "outside." In this…”
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Retinoic Acid-Related Orphan Receptor α Is Required for Generation of Th2 Cells in Type 2 Pulmonary Inflammation by Roberts, Joseph, Chevalier, Anne, Hawerkamp, Heike C, Yeow, Aoife, Matarazzo, Laura, Schwartz, Christian, Hams, Emily, Fallon, Padraic G

“…The transcription factor retinoic acid-related orphan receptor α (RORα) is important in regulating several physiological functions, such as cellular…”
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Innate PD-L1 limits T cell-mediated adipose tissue inflammation and ameliorates diet-induced obesity by Schwartz, Christian, Schmidt, Viviane, Deinzer, Andrea, Hawerkamp, Heike C, Hams, Emily, Bayerlein, Jasmin, Röger, Ole, Bailer, Moritz, Krautz, Christian, El Gendy, Amr, Elshafei, Moustafa, Heneghan, Helen M, Hogan, Andrew E, O'Shea, Donal, Fallon, Padraic G

“…Obesity has become a major health problem in the industrialized world. Immune regulation plays an important role in adipose tissue homeostasis; however, the…”
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Interleukin-26 activates macrophages and facilitates killing of Mycobacterium tuberculosis by Hawerkamp, Heike C., van Geelen, Lasse, Korte, Jan, Di Domizio, Jeremy, Swidergall, Marc, Momin, Afaque A., Guzmán-Vega, Francisco J., Arold, Stefan T., Ernst, Joachim, Gilliet, Michel, Kalscheuer, Rainer, Homey, Bernhard, Meller, Stephan

“…Tuberculosis-causing Mycobacterium tuberculosis (Mtb) is transmitted via airborne droplets followed by a primary infection of macrophages and dendritic cells…”
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Vemurafenib acts as an aryl hydrocarbon receptor antagonist: Implications for inflammatory cutaneous adverse events by Hawerkamp, Heike C., Kislat, Andreas, Gerber, Peter A., Pollet, Marius, Rolfes, Katharina M., Soshilov, Anatoly A., Denison, Michael S., Momin, Afaque A., Arold, Stefan T., Datsi, Angeliki, Braun, Stephan A., Oláh, Péter, Lacouture, Mario E., Krutmann, Jean, Haarmann‐Stemmann, Thomas, Homey, Bernhard, Meller, Stephan

“…Background In recent years, the BRAF inhibitor vemurafenib has been successfully established in the therapy of advanced melanoma. Despite its superior…”
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Emergence of dysfunctional neutrophils with a defect in arginase-1 release in severe COVID-19 by Dwivedi, Amrita, Ui Mhaonaigh, Aisling, Carroll, Makala, Khosravi, Bahareh, Batten, Isabella, Ballantine, Robert Seán, Hendricken Phelan, Stuart, O'Doherty, Laura, George, Angel Mary, Sui, Jacklyn, Hawerkamp, Heike C, Fallon, Padraic G, Noppe, Elnè, Mason, Sabina, Conlon, Niall, Ni Cheallaigh, Clíona, Finlay, Conor M, Little, Mark A, Bioresource, On Behalf Of The St James's And Tallaght Trinity Allied Researchers Sttar

“…Neutrophilia occurs in patients infected with SARS-CoV-2 (COVID-19) and is predictive of poor outcomes. Here, we link heterogenous neutrophil populations to…”
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Discovery and multi-parametric optimization of a high-affinity antibody against interleukin-25 with neutralizing activity in a mouse model of skin inflammation by Bone, Ruth, Fennell, Brian J, Tam, Amy, Sheldon, Richard, Nocka, Karl, Varghese, Sreeja, Chang, Chew Shun, Hawerkamp, Heike C, Yeow, Aoife, Saunders, Sean P, Hams, Emily, Walsh, Patrick T, Cunningham, Orla, Fallon, Padraic G

“…Abstract Background Interleukin (IL)25 has been implicated in tissue homeostasis at barrier surfaces and the initiation of type two inflammatory signaling in…”
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2022 International Women's Day ‐ yEFIS highlights outstanding women vaccine researchers

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