Search Results - "Havrda, Matthew C"

Glioma Cell Secretion: A Driver of Tumor Progression and a Potential Therapeutic Target by Almiron Bonnin, Damian A, Havrda, Matthew C, Israel, Mark A

“…Cellular secretion is an important mediator of cancer progression. Secreted molecules in glioma are key components of complex autocrine and paracrine pathways…”
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Slc6a3-dependent expression of a CAPS-associated Nlrp3 allele results in progressive behavioral abnormalities and neuroinflammation in aging mice by von Herrmann, Katharine M, Anderson, Faith L, Martinez, Eileen M, Young, Alison L, Havrda, Matthew C

“…An association between neuroinflammation and age-related neurologic disorders has been established but the molecular mechanisms and cell types involved have…”
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Inhibiting the Cholesterol Storage Enzyme ACAT1/SOAT1 in Myelin Debris-Treated Microglial Cell Lines Activates the Gene Expression of Cholesterol Efflux Transporter ABCA1 by Huynh, Thao N, Havrda, Matthew C, Zanazzi, George J, Chang, Catherine C Y, Chang, Ta Yuan

“…Aging is the major risk factor for Alzheimer's disease (AD). In the aged brain, myelin debris accumulates and is cleared by microglia. Phagocytosed myelin…”
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Phosphorylation Regulates Id2 Degradation and Mediates the Proliferation of Neural Precursor Cells by Sullivan, Jaclyn M., Havrda, Matthew C., Kettenbach, Arminja N., Paolella, Brenton R., Zhang, Zhonghua, Gerber, Scott A., Israel, Mark A.

“…Inhibitor of DNA binding proteins (Id1‐Id4) function to inhibit differentiation and promote proliferation of many different cell types. Among the Id family…”
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Plasma-borne indicators of inflammasome activity in Parkinson’s disease patients by Anderson, Faith L., von Herrmann, Katharine M., Andrew, Angeline S., Kuras, Yuliya I., Young, Alison L., Scherzer, Clemens R., Hickey, William F., Lee, Stephen L., Havrda, Matthew C.

“…Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms and loss of dopaminergic neurons of the substantia…”
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Lifestyle Factors and Parkinson’s Disease Risk in a Rural New England Case-Control Study by Andrew, Angeline S., Anderson, Faith L., Lee, Stephen L., Von Herrmann, Katharine M., Havrda, Matthew C.

“…Introduction. Parkinson’s disease (PD) is an age-related neurodegenerative disease likely caused by complex interactions between genetic and environmental risk…”
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Integration of Notch 1 and Calcineurin/NFAT Signaling Pathways in Keratinocyte Growth and Differentiation Control by Mammucari, Cristina, di Vignano, Alice Tommasi, Sharov, Andrey A., Neilson, Joel, Havrda, Matthew C., Roop, Dennis R., Botchkarev, Vladimir A., Crabtree, Gerald R., Dotto, G. Paolo

“…The Notch and Calcineurin/NFAT pathways have both been implicated in control of keratinocyte differentiation. Induction of the p21 WAF1/Cip1 gene by Notch 1…”
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Id2 Is Required for Specification of Dopaminergic Neurons during Adult Olfactory Neurogenesis by Havrda, Matthew C, Harris, Brent T, Mantani, Akio, Ward, Nora M, Paolella, Brenton R, Cuzon, Verginia C, Yeh, Hermes H, Israel, Mark A

“…Understanding the biology of adult neural stem cells has important implications for nervous system development and may contribute to our understanding of…”
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NLRP3 inflammasome in neurodegenerative disease by Anderson, Faith L., Biggs, Karl E., Rankin, Brynn E., Havrda, Matthew C.

“…Neurodegenerative diseases are characterized by a dysregulated neuro-glial microenvironment, culminating in functional deficits resulting from neuronal cell…”
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Behavioral abnormalities and Parkinson's-like histological changes resulting from Id2 inactivation in mice by Havrda, Matthew C, Paolella, Brenton R, Ward, Nora M, Holroyd, Kathryn B

“…Characterizing dopaminergic neuronal development and function in novel genetic animal models might uncover strategies for researchers to develop…”
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Inflammasomes: An Emerging Mechanism Translating Environmental Toxicant Exposure Into Neuroinflammation in Parkinson’s Disease by Anderson, Faith L, Coffey, Madeleine M, Berwin, Brent L, Havrda, Matthew C

“…Abstract Evidence indicates that complex gene-environment interactions underlie the incidence and progression of Parkinson’s disease (PD). Neuroinflammation is…”
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Bbc3 Loss Enhances Survival and Protein Clearance in Neurons Exposed to the Organophosphate Pesticide Chlorpyrifos by Anderson, Faith L, von Herrmann, Katharine M, Young, Alison L, Havrda, Matthew C

“…Abstract Exposure to environmental toxicants can increase the risk of developing age-related neurodegenerative disorders. Exposure to the widely used…”
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NLRP3 expression in mesencephalic neurons and characterization of a rare NLRP3 polymorphism associated with decreased risk of Parkinson’s disease by von Herrmann, Katharine M., Salas, Lucas A., Martinez, Eileen M., Young, Alison L., Howard, Joseph M., Feldman, Mary S., Christensen, Brock C., Wilkins, Owen M., Lee, Stephen L., Hickey, William F., Havrda, Matthew C.

“…Neuroinflammation is a well-characterized pathophysiology occurring in association with the progression of Parkinson’s disease. Characterizing the cellular and…”
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Facile method to incorporate high-affinity ACAT/SOAT1 inhibitor F12511 into stealth liposome-based nanoparticle and demonstration of its efficacy in blocking cholesteryl ester biosynthesis without overt toxicity in neuronal cell culture by De La Torre, Adrianna L., Smith, Caleb, Granger, Joseph, Anderson, Faith L., Harned, Taylor C., Havrda, Matthew C., Chang, Catherine C.Y., Chang, Ta-Yuan

“…Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors have been considered as potential therapeutic agents to treat several diseases, including Alzheimer’s…”
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Characterizing the heterogeneity in 5-aminolevulinic acid-induced fluorescence in glioblastoma by Almiron Bonnin, Damian A, Havrda, Matthew C, Lee, Myung Chang, Evans, Linton, Ran, Cong, Qian, David C, Harrington, Lia X, Valdes, Pablo A, Cheng, Chao, Amos, Chris I, Harris, Brent T, Paulsen, Keith D, Roberts, David W, Israel, Mark A

“…5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence is an effective surgical adjunct for the intraoperative identification of tumor…”
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ID2 promotes survival of glioblastoma cells during metabolic stress by regulating mitochondrial function by Zhang, Zhonghua, Rahme, Gilbert J, Chatterjee, Pranam D, Havrda, Matthew C, Israel, Mark A

“…Tumor cells proliferate in cellular environments characterized by a lack of optimal tissue organization resulting oftentimes in compromised cellular metabolism…”
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Insulin-Mediated Signaling Facilitates Resistance to PDGFR Inhibition in Proneural hPDGFB-Driven Gliomas by Almiron Bonnin, Damian A, Ran, Cong, Havrda, Matthew C, Liu, Huan, Hitoshi, Yasuyuki, Zhang, Zhonghua, Cheng, Chao, Ung, Matthew, Israel, Mark A

“…Despite abundant evidence implicating receptor tyrosine kinases (RTK), including the platelet-derived growth factor receptor (PDGFR), in the pathogenesis of…”
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Abstract 141: HEY1-mediated inhibition of glioma stem cell proliferation is associated with restoration of glioma stem cell division asymmetry and transcriptional repression of PDGFRA by Bonnin, Damian A. Almiron, Sullivan, Jaclyn, Israel, Mark A., Havrda, Matthew Havrda C.

“…Abstract Emerging evidence suggests that deregulation of cell-fate regulatory mechanisms in subpopulations of stem-like tumor cells can contribute to the…”
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The effect of botulinum toxin on ureteral inflammation by Krughoff, Kevin, Anderson, Faith L., Palisoul, Scott, Young, Alison L., R. Pettus, Jason, L. Moodie, Karen, Ogomo, Christopher, S. Tau, Steven, A. Moses, Rachel, Havrda, Matthew C., R. Chavez, David

“…Purpose The impact of onabotulinum toxin type A (BoNT-A) on bladder afferent nerve pathways and chemosensory functions is an active area of investigation…”
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Id2 Mediates Oligodendrocyte Precursor Cell Maturation Arrest and Is Tumorigenic in a PDGF-Rich Microenvironment by HAVRDA, Matthew C, PAOLELLA, Brenton R, CONG RAN, JERING, Karola S, WRAY, Christina M, SULLIVAN, Jaclyn M, NAILOR, Audrey, HITOSHI, Yasuyuki, ISRAEL, Mark A

“…Maturation defects occurring in adult tissue progenitor cells have the potential to contribute to tumor development; however, there is little experimental…”
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