Search Results - "Havlik, L. Patrick"

The membrane associated accessory protein is an adeno-associated viral egress factor by Elmore, Zachary C., Patrick Havlik, L., Oh, Daniel K., Anderson, Leif, Daaboul, George, Devlin, Garth W., Vincent, Heather A., Asokan, Aravind

“…Adeno-associated viruses (AAV) rely on helper viruses to transition from latency to lytic infection. Some AAV serotypes are secreted in a pre-lytic manner as…”
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Coevolution of Adeno-associated Virus Capsid Antigenicity and Tropism through a Structure-Guided Approach by Havlik, L Patrick, Simon, Katherine E, Smith, J Kennon, Klinc, Kelli A, Tse, Longping V, Oh, Daniel K, Fanous, Marco M, Meganck, Rita M, Mietzsch, Mario, Kleinschmidt, Jürgen, Agbandje-McKenna, Mavis, Asokan, Aravind

“…Adeno-associated viruses (AAV) are composed of nonenveloped, icosahedral protein shells that can be adapted to package and deliver recombinant therapeutic DNA…”
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Cross-species evolution of a highly potent AAV variant for therapeutic gene transfer and genome editing by Gonzalez, Trevor J., Simon, Katherine E., Blondel, Leo O., Fanous, Marco M., Roger, Angela L., Maysonet, Maribel Santiago, Devlin, Garth W., Smith, Timothy J., Oh, Daniel K., Havlik, L. Patrick, Castellanos Rivera, Ruth M., Piedrahita, Jorge A., ElMallah, Mai K., Gersbach, Charles A., Asokan, Aravind

“…Recombinant adeno-associated viral (AAV) vectors are a promising gene delivery platform, but ongoing clinical trials continue to highlight a relatively narrow…”
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Capsid-mediated control of adeno-associated viral transcription determines host range by Loeb, Ezra J., Havlik, Patrick L., Elmore, Zachary C., Rosales, Alan, Fergione, Sophia M., Gonzalez, Trevor J., Smith, Timothy J., Benkert, Abigail R., Fiflis, David N., Asokan, Aravind

“…Adeno-associated virus (AAV) is a member of the genus Dependoparvovirus, which infects a wide range of vertebrate species. Here, we observe that, unlike most…”
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Structure-guided evolution of antigenically distinct adeno-associated virus variants for immune evasion by Tse, Longping Victor, Klinc, Kelli A., Madigan, Victoria J., Rivera, Ruth M. Castellanos, Wells, Lindsey F., Havlik, L. Patrick, Smith, J. Kennon, Agbandje-McKenna, Mavis, Asokan, Aravind

“…Preexisting neutralizing antibodies (NAbs) against adeno-associated viruses (AAVs) pose a major, unresolved challenge that restricts patient enrollment in gene…”
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Receptor Switching in Newly Evolved Adeno-associated Viruses by Havlik, L Patrick, Das, Anshuman, Mietzsch, Mario, Oh, Daniel K, Ark, Jonathan, McKenna, Robert, Agbandje-McKenna, Mavis, Asokan, Aravind

“…Adeno-associated viruses utilize different glycans and the AAV receptor (AAVR) for cellular attachment and entry. Directed evolution has yielded new AAV…”
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An evolved AAV variant enables efficient genetic engineering of murine T cells by Nyberg, William A., Ark, Jonathan, To, Angela, Clouden, Sylvanie, Reeder, Gabriella, Muldoon, Joseph J., Chung, Jing-Yi, Xie, William H., Allain, Vincent, Steinhart, Zachary, Chang, Christopher, Talbot, Alexis, Kim, Sandy, Rosales, Alan, Havlik, L. Patrick, Pimentel, Harold, Asokan, Aravind, Eyquem, Justin

“…Precise targeting of large transgenes to T cells using homology-directed repair has been transformative for adoptive cell therapies and T cell biology…”
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