Search Results - "Haviv, Fortuna"

Preclinical Evaluation of Antiangiogenic Thrombospondin-1 Peptide Mimetics, ABT-526 and ABT-510, in Companion Dogs with Naturally Occurring Cancers by RUSK, Anthony, MCKEEGAN, Evelyn, HAVIV, Fortuna, MAJEST, Sandra, HENKIN, Jack, KHANNA, Chand

“…Purpose: The angiogenic phenotype of malignant cancers has been established as a target for cancer therapy. ABT-526 and ABT-510, two peptide mimetics of…”
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Thrombospondin-1 Mimetic Peptide Inhibitors of Angiogenesis and Tumor Growth:  Design, Synthesis, and Optimization of Pharmacokinetics and Biological Activities by Haviv, Fortuna, Bradley, Michael F, Kalvin, Douglas M, Schneider, Andrew J, Davidson, Donald J, Majest, Sandra M, McKay, Laura M, Haskell, Catherine J, Bell, Randy L, Nguyen, Bach, Marsh, Kennan C, Surber, Bruce W, Uchic, John T, Ferrero, James, Wang, Yi-Chun, Leal, Juan, Record, Rae D, Hodde, Jason, Badylak, Stephen F, Lesniewski, Richard R, Henkin, Jack

“…The heptapeptide 1, NAc-Gly-Val-DIle-Thr-Arg-Ile-ArgNHEt, a structurally modified fragment derived from the second type-1 repeat of thrombospondin-1 (TSP-1),…”
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Effect of N-methyl substitution of the peptide bonds in luteinizing hormone-releasing hormone agonists by Haviv, Fortuna, Fitzpatrick, Timothy D, Swenson, Rolf E, Nichols, Charles J, Mort, Nicholas A, Bush, Eugene N, Diaz, Gilbert, Bammert, Gary, Nguyen, A

“…Each peptide bond in leuprolide (1), deslorelin (13), and nafarelin (24) was separately substituted with N-methyl. The synthesized compounds were tested for in…”
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Inhibition of tumor growth by systemic treatment with thrombospondin‐1 peptide mimetics by Reiher, Frank K., Volpert, Olga V., Jimenez, Benilde, Crawford, Susan E., Dinney, Colin P., Henkin, Jack, Haviv, Fortuna, Bouck, Noel P., Campbell, Steven C.

“…Many normal human cells produce thrombospondin‐1 (TSP‐1), a potent antiangiogenic protein that promotes vascular quiescence. In various organ systems,…”
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Refolding of misfolded mutant GPCR: Post-translational pharmacoperone action in vitro by Janovick, Jo Ann, Brothers, Shaun P., Cornea, Anda, Bush, Eugene, Goulet, Mark T., Ashton, Wallace T., Sauer, Daryl R., Haviv, Fortuna, Greer, Jonathan, Michael Conn, P.

“…All reported GnRH receptor mutants (causing human hypogonadotropic hypogonadism) are misfolded proteins that cannot traffic to the plasma membrane…”
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In vitro and in vivo Activities of Reduced-Size Antagonists of Luteinizing Hormone-Releasing Hormone by Haviv, Fortuna, Fitzpatrick, Timothy D, Nichols, Charles J, Bush, Eugene N, Diaz, Gilbert, Bammert, Gary, Nguyen, A. T, Johnson, Edwin S, Knittle, Judith, Greer, Jonathan

“…A novel series of octapeptide LHRH antagonists was designed on the basis of the structure of the (2-9) fragment of a LHRH agonist. By adopting a systematic SAR…”
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Structural requirements for the inhibition of 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid analogs by Haviv, Fortuna, Ratajczyk, James D, DeNet, Robert W, Martin, Yvonne C, Dyer, Richard D, Carter, George W

“…The structural requirements for inhibition of RBL-1 (rat basophilic leukemia) 5-lipoxygenase by 15-hydroxyeicosa-5,8,11,13-tetraenoic acid (15-HETE, 1) were…”
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Nonpeptide Luteinizing Hormone-Releasing Hormone Antagonists Derived from Erythromycin A:  Design, Synthesis, and Biological Activity of Cladinose Replacement Analogues by Randolph, John T, Waid, Philip, Nichols, Charles, Sauer, Daryl, Haviv, Fortuna, Diaz, Gilbert, Bammert, Gary, Besecke, Leslie M, Segreti, Jason A, Mohning, Kurt M, Bush, Eugene N, Wegner, Craig D, Greer, Jonathan

“…The design and synthesis of a series of 11,12-cyclic carbamate derivatives of 6-O-methylerythromycin A that are novel, nonpeptide LHRH antagonists, is…”
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Elimination of antibacterial activities of non-peptide luteinizing hormone-releasing hormone (LHRH) antagonists derived from erythromycin A by Randolph, John T, Sauer, Daryl R, Haviv, Fortuna, Nilius, Angela M, Greer, Jonathan

“…Antibacterial SAR for a series of macrolides derived from erythromycin A that are potent LHRH antagonists was developed in an attempt to eliminate the…”
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Condensations of 4-methyl-4-dichloromethyl-2,5-cyclohexadienone by Wenkert, Ernest, Haviv, Fortuna, Zeitlin, Adela

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3-[1-(2-Benzoxazolyl)hydrazino]propanenitrile derivatives: inhibitors of immune complex induced inflammation by Haviv, Fortuna, Ratajczyk, James D, DeNet, Robert W, Kerdesky, Francis A, Walters, Roland L, Schmidt, Steven P, Holms, James H, Young, Patrick R, Carter, George W

“…3-[1-(2-Benzoxazolyl)hydrazino]propanenitrile derivatives were evaluated in the dermal and pleural reverse passive Arthus reactions in the rat. In the pleural…”
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Pharmacological and endocrine characterization of A-198401, an orally active GnRH antagonist, in intact and castrate male rat models by Besecke, Leslie M., Diaz, Gilbert J., Segreti, Jason A., Mohning, Kurt M., Cybulski, Van A., Rao, Mira, Bush, Eugene N., Randolph, John T., Waid, Philip L., Haviv, Fortuna, Wegner, Craig D., Greer, Jonathan

“…Gonadotropin‐releasing hormone (GnRH) stimulates the synthesis and secretion of the gonadotropins that maintain the reproductive axis in mammals. Efforts have…”
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Differential orientation of a GnRH agonist and antagonist in the pituitary GnRH receptor by Janovick, J A, Haviv, F, Fitzpatrick, T D, Conn, P M

“…In the present study we have used a high affinity photoaffinity label (PAL) agonist (pGlu-His-Trp-Ser-125I-iodoTyr-D-Lys(para-N3-Benzoyl)-Leu-Arg-P roNHEt) and…”
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Stabilization of the N-terminal residues of luteinizing hormone-releasing hormone agonists and the effect on pharmacokinetics by Haviv, Fortuna, Fitzpatrick, Timothy D, Nichols, Charles J, Swenson, Rolf E, Bush, Eugene N, Diaz, Gilbert, Nguyen, A, Nellans, Hugh N, Hoffman, Daniel J

“…To stabilize leuprolide (1) against chymotrypsin and intestinal degradation several agonists of LHRH (2-12), modified at position 1, 2, or 3 and/or containing…”
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Active reduced-size hexapeptide analogs of luteinizing hormone-releasing hormone by Haviv, Fortuna, Palabrica, Christopher A, Bush, Eugene N, Diaz, Gilbert, Johnson, Edwin S, Love, Stephen, Greer, Jonathan

“…A series of reduced-size hexapeptide analogues of LH-RH were synthesized that contain the residues corresponding to amino acid positions 4-9 and are linked to…”
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The effect of NMeTyr5 substitution in luteinizing hormone-releasing hormone antagonists by Haviv, Fortuna, Fitzpatrick, Timothy D, Nichols, Charles J, Swenson, Rolf E, Mort, Nicholas A, Bush, Eugene N, Diaz, Gilbert, Nguyen, A. T, Holst, Mark R

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Inhibitors of immune complex-induced inflammation: 3-[1-(2-benzoxazolyl)hydrazino]propanenitrile derivatives by Kim, K H, Martin, Y C, Norris, B, Haviv, F

“…The octanol-water partition coefficients (log P) and the dissociation constants (pKa) of 3-[1-(2-benzoxazolyl)hydrazino]propanenitrile analogues have been…”
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Inhibitors of immune complex-induced inflammation: 5-substituted 3-[1-(2-benzoxazolyl)hydrazino]propanenitrile derivatives by Kim, K H, Martin, Y C, Young, P R, Carter, G W, Haviv, F

“…A number of 5-substituted 3-[1-(2-benzoxazolyl)hydrazino]propanenitrile analogues have been studied as inhibitors of the rat pleural reverse passive Arthus…”
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Transformations of 1-methyl-1-(dichloromethyl)cyclohexane derivatives by Wenkert, Ernest, Bakuzis, Peter, Haviv, Fortuna

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2-[(Phenylthio)methyl]pyridine derivatives: new antiinflammatory agents by Haviv, Fortuna, DeNet, Robert W, Michaels, Raymond J, Ratajczyk, James D, Carter, George W, Young, Patrick R

“…2-[(Phenylthio)methyl]pyridine derivatives inhibited the dermal reverse passive Arthus reaction (RPAR) in the rat. In the same model, indomethacin was…”
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