Search Results - "Haver, Dirk Van"

Synthesis and biological activity of 22-oxa CD-ring modified analogues of 1α, 25-dihydroxyvitamin D3: Spiro[5.5]undecane CF-ring analogues by SCHEPENS, Wim, VAN HAVER, Dirk, VANDEWALLE, Maurits, DE CLERCQ, Pierre J, BOUILLON, Roger, VERSTUYF, Annemieke

Get full text

Synthesis and biological activity of 22-oxa CD-ring modified analogues of 1α, 25-dihydroxyvitamin D3: cis-perhydrindane CE-ring analogues by DEMIN, Samuël, VAN HAVER, Dirk, VANDEWALLE, Maurits, DE CLERCQ, Pierre J, BOUILLON, Roger, VERSTUYF, Annemieke

Get full text

Synthesis and biological activity of 22-oxa CD-ring modified analogues of 1alpha,25-dihydroxyvitamin D3: spiro[5.5]undecane CF-ring analogues by Schepens, Wim, Van Haver, Dirk Van, Vandewalle, Maurits, De Clercq, Pierre J, Bouillon, Roger, Verstuyf, Annemieke

“…The synthesis and biological activity of novel CD-ring modified analogues of 22-oxa-1alpha,25-dihydroxyvitamin D(3), lacking the D-ring and featuring a…”
Get full text

Previtamin D3 with a trans-Fused Decalin CD-ring Has Pronounced Genomic Activity by Verlinden, Lieve, Verstuyf, Annemieke, Verboven, Christel, Eelen, Guy, De Ranter, Camiel, Gao, Ling-Jie, Chen, Yong-Jun, Murad, Ibrahim, Choi, Mihwa, Yamamoto, Keiko, Yamada, Sachiko, Van Haver, Dirk, Vandewalle, Maurits, De Clercq, Pierre J., Bouillon, Roger

“…Deletion of C19 in the structure of 1α,25-dihydroxyvitamin D3 [1,25(OH)2D3] does not substantially alter the biological potency but prevents the conversion…”
Get full text

Asymmetric synthesis of (7aS)-7a-methyl-4,5,7,7a-tetrahydro-1H-indene-2,6-dione and useful derivatives thereof by Demin, Samuël, Van Haver, Dirk, De Clercq, Pierre J

“…The enantioselective synthesis of the title compound, using Meyers' bicyclic lactam methodology, is described. This compound and a few of its derivatives are…”
Get full text

A Short Intramolecular Diels−Alder Route to Himbacine Derivatives by Hofman, Sven, Gao, Ling-Jie, Van Dingenen, Hilde, Hosten, Noël G. C., Van Haver, Dirk, De Clercq, Pierre J., Milanesio, Marco, Viterbo, Davide

“…The intramolecular cycloaddition of 5 yields the unsaturated lactones 17a, 17b, and 17c as three major isomeric adducts. These were further reduced to the…”
Get full text

Synthesis and affinity studies of himbacine derived muscarinic receptor antagonists by Gao, Ling-Jie, Waelbroeck, Magali, Hofman, Sven, Van Haver, Dirk, Milanesio, Marco, Viterbo, Davide, De Clercq, Pierre J

“…A series of himbacine ( 1)-related analogues has been prepared featuring three different isomeric configurations with respect to the B-ring ( a, b and natural…”
Get full text

Synthesis and binding affinity studies of muscarinic receptor antagonists related to dehydrohimbacine by Gao, Ling-Jie, Cauwenberge, Gunther Van, Hosten, Noël, Haver, Dirk Van, Waelbroeck, Magali, Clercq, Pierre J. De

Get full text

Permeability of the blood-brain barrier for atenolol studied by positron emission tomography by Agon, P, Goethals, P, Van Haver, D, Kaufman, J M

“…The permeability of the blood-brain barrier for atenolol, a hydrophilic beta-adrenergic blocking agent, has been assessed in dogs, by studying the distribution…”
Get more information

Synthesis of Spiro[4.5]decane CF-Ring Analogues of 1α,25-Dihydroxyvitamin D 3 by Schepens, Wim, Van Haver, Dirk, Vandewalle, Maurits, Bouillon, Roger, Verstuyf, Annemieke, De Clercq, Pierre J.

Get full text

Development of Analogues of 1α,25‐Dihydroxyvitamin D 3 with Biased Side‐Chain Orientation: C20 Methylated Des‐C,D‐homo Analogues by Vrielynck, Freek, Van Haver, Dirk, Vandewalle, Maurits, Verlinden, Lieve, Verstuyf, Annemieke, Bouillon, Roger, Croce, Gianluca, De Clercq, Pierre

“…Abstract The discovery that 1α,25‐dihydroxyvitamin D 3 is effective in the inhibition of cellular proliferation and in the induction of cellular…”
Get full text

Synthesis of Spiro[4.5]decane CF-Ring Analogues of 1α,25-Dihydroxyvitamin D3 by Schepens, Wim, Van Haver, Dirk, Vandewalle, Maurits, Bouillon, Roger, Verstuyf, Annemieke, De Clercq, Pierre J

“…A novel series of analogues of calcitriol (1) is developed featuring a spirocyclic central core resulting from C18/C21-connection and C15/C16-deletion (2a,…”
Get full text

Development of Analogues of la,25-Dihydroxyvitamin D3 with Biased Side-Chain Orientation : C20 Methylated Des-C,D-homo Analogues by VRIELYNCK, Freek, VAN HAVER, Dirk, VANDEWALLE, Maurits, VERLINDEN, Lieve, VERSTUYF, Annemieke, BOUILLON, Roger, CROCE, Gianluca, DE CLERCQ, Pierre

Get full text

The development of CD-ring modified analogs of 1α,25-dihydroxyvitamin D by De Clercq, Pierre J., De Buysser, Frederik, Minne, Garrett, Schepens, Wim, Vrielynck, Freek, Van Haver, Dirk, Vandewalle, Maurits, Verstuyf, Annemieke, Bouillon, Roger

“…During a 20-year collaboration the laboratories of UGent and KU Leuven have developed different series of Vitamin D analogs characterized by structural…”
Get full text

Synthesis, biological activity, and conformational analysis of CD-ring modified trans-decalin 1 alpha,25-dihydroxyvitamin D analogs by Chen, Yong-Jun, Gao, Ling-Jie, Murad, Ibrahim, Verstuyf, Annemieke, Verlinden, Lieve, Verboven, Christel, Bouillon, Roger, Viterbo, Davide, Milanesio, Marco, Van Haver, Dirk, Vandewalle, Maurits, De Clercq, Pierre J

“…A novel series of analogs of 1,25-dihydroxyvitamin D3, the hormonally active metabolite of vitamin D3, characterised by the presence of a trans-fused decalin…”
Get more information

The development of CD-ring modified analogs of 1alpha,25-dihydroxyvitamin D by De Clercq, Pierre J, De Buysser, Frederik, Minne, Garrett, Schepens, Wim, Vrielynck, Freek, Van Haver, Dirk, Vandewalle, Maurits, Verstuyf, Annemieke, Bouillon, Roger

“…During a 20-year collaboration the laboratories of UGent and KU Leuven have developed different series of Vitamin D analogs characterized by structural…”
Get full text

Development of Analogues of 1α,25-Dihydroxyvitamin D3 with Biased Side Chain Orientation: Methylated Des-C,D-Homo Analogues by Gabriëls, Stefan, Van Haver, Dirk, Vandewalle, Maurits, De Clercq, Pierre, Verstuyf, Annemieke, Bouillon, Roger

“…The discovery that 1α,25‐dihydroxyvitamin D3 is effective in the inhibition of cellular proliferation and in the induction of cellular differentiation has led…”
Get full text

Synthesis and biological activity of 22-oxa CD-ring modified analogues of 1alpha,25-dihydroxyvitamin D3: cis-perhydrindane CE-ring analogues by Demin, Samuël, Van Haver, Dirk, Vandewalle, Maurits, De Clercq, Pierre J, Bouillon, Roger, Verstuyf, Annemieke

“…The synthesis and biological activity of novel CD-ring modified analogues of 22-oxa-1alpha,25-dihydroxyvitamin D(3), lacking the D-ring and featuring a…”
Get full text

Synthesis and biological activity of 22-oxa CD-ring modified analogues of 1α,25-dihydroxyvitamin D 3: spiro[5.5]undecane CF-ring analogues by Schepens, Wim, Haver, Dirk Van, Vandewalle, Maurits, De Clercq, Pierre J, Bouillon, Roger, Verstuyf, Annemieke

“…The synthesis and biological activity of novel CF-ring 22-oxa-1α,25(OH) 2D 3 analogues is described. The synthesis and biological activity of novel CD-ring…”
Get full text

Biological Activity of CD‐Ring Modified 1α,25‐Dihydroxyvitamin D Analogues: C‐Ring and Five‐Membered D‐Ring Analogues by Verstuyf, Annemieke, Verlinden, Lieve, Van Etten, Evelyne, Shi, Ling, Wu, Yusheng, D'Halleweyn, Chris, Van Haver, Dirk, Zhu, Gui‐Dong, Chen, Yong‐Jun, Zhou, Xiaoming, Haussler, Mark R., De Clercq, Pierre, Vandewalle, Maurits, Van Baelen, Hugo, Mathieu, Chantal, Bouillon, Roger

“…Nonsteroidal analogues of 1α,25(OH)2D3, lacking either the full five‐membered D ring (C‐ring analogues) or the full six‐membered C ring (D‐ring analogues) are…”
Get full text