Search Results - "Havekes, LM"

Effect of the APOE-491A/T promoter polymorphism on apolipoprotein E levels and risk of Alzheimer disease: The Rotterdam Study by Roks, G., Cruts, M., Houwing-Duistermaat, J.J., Dermaut, B., Serneels, S., Havekes, L.M., Hofman, A., Breteler, M.M.B., Van Broeckhoven, C., van Duijn, C.M.

“…The apolipoprotein E (APOE) gene is involved in lipid transport. A common polymorphism in this gene with the APOE*2, APOE*3, and APOE*4 alleles influences…”
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Hepatic Steatosis: A Mediator of the Metabolic Syndrome. Lessons From Animal Models by den Boer, M, Voshol, P.J, Kuipers, F, Havekes, L.M, Romijn, J.A

“…ABSTRACT—Epidemiological studies in humans, as well as experimental studies in animal models, have shown an association between visceral obesity and…”
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LDL receptor cooperates with LDL receptor–related protein in regulating plasma levels of coagulation factor VIII in vivo by Bovenschen, Niels, Mertens, Koen, Hu, Lihui, Havekes, Louis M., van Vlijmen, Bart J.M.

“…Low-density lipoprotein (LD55558) receptor (LDLR) and LDLR-related protein (LRP) are members of the LDLR family of endocytic receptors. LRP recognizes a wide…”
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Stimulation of Lipogenesis by Pharmacological Activation of the Liver X Receptor Leads to Production of Large, Triglyceride-rich Very Low Density Lipoprotein Particles by Grefhorst, Aldo, Elzinga, Baukje M., Voshol, Peter J., Plo¨sch, Torsten, Kok, Tineke, Bloks, Vincent W., van der Sluijs, Fjodor H., Havekes, Louis M., Romijn, Johannes A., Verkade, Henkjan J., Kuipers, Folkert

“…The oxysterol-activated liver X receptor (LXR) provides a link between sterol and fatty acid metabolism; activation of LXR induces transcription of lipogenic…”
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ApoAV Reduces Plasma Triglycerides by Inhibiting Very Low Density Lipoprotein-Triglyceride (VLDL-TG) Production and Stimulating Lipoprotein Lipase-mediated VLDL-TG Hydrolysis by Schaap, Frank G, Rensen, Patrick C N, Voshol, Peter J, Vrins, Carlos, van der Vliet, Hendrik N, Chamuleau, Robert A F M, Havekes, Louis M, Groen, Albert K, van Dijk, Ko Willems

“…ApoAV has been discovered recently as a novel modifier of triglyceride (TG) metabolism, but the pathways involved are currently unknown. To gain insight into…”
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Metabolomics in the context of systems biology: bridging traditional Chinese medicine and molecular pharmacology by Wang, Mei, Lamers, Robert-Jan A. N., Korthout, Henrie A. A. J., van Nesselrooij, Joop H. J., Witkamp, Renger F., van der Heijden, Rob, Voshol, Peter J., Havekes, Louis M., Verpoorte, Rob, van der Greef, Jan

“…The introduction of the concept of systems biology, enabling the study of living systems from a holistic perspective based on the profiling of a multitude of…”
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Selective parasympathetic innervation of subcutaneous and intra-abdominal fat -- functional implications by Kreier, F, Fliers, E, Voshol, P J, Van Eden, CG, Havekes, L M, Kalsbeek, A, Van Heijningen, CL, Sluiter, A A, Mettenleiter, T C, Romijn, JA, Sauerwein, H P, Buijs, R M

“…The wealth of clinical epidemiological data on the association between intra-abdominal fat accumulation and morbidity sharply contrasts with the paucity of…”
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Role of ApoCs in Lipoprotein Metabolism: Functional Differences Between ApoC1, ApoC2, and ApoC3 by Jong, Miek C, Hofker, Marten H, Havekes, Louis M

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Severe hypertriglyceridemia in human APOC1 transgenic mice is caused by apoC-I-induced inhibition of LPL by Berbée, Jimmy F.P., van der Hoogt, Caroline C., Sundararaman, Deepa, Havekes, Louis M., Rensen, Patrick C.N.

“…Studies in humans and mice have shown that increased expression of apolipoprotein C-I (apoC-I) results in combined hyperlipidemia with a more pronounced effect…”
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The role of apolipoprotein E in the elimination of liposomes from blood by hepatocytes in the mouse by Yan, Xuedong, Kuipers, Folkert, Havekes, Louis M., Havinga, Rick, Dontje, Bert, Poelstra, Klaas, Scherphof, Gerrit L., Kamps, Jan A.A.M.

“…We evaluated the role of apolipoprotein E (apoE) in the clearance of neutral and negatively charged liposomes by hepatocytes in apoE-deficient mice. Negatively…”
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Rosuvastatin reduces atherosclerosis development beyond and independent of its plasma cholesterol-lowering effect in APOE3-Leiden transgenic mice: Evidence for antiinflammatory effects of rosuvastatin by KLEEMANN, Robert, PRINCEN, Hans M. G, EMEIS, Jef J, JUKEMA, J. Wouter, FONTIJN, Ruud D, HORREVOETS, Anton J. G, KOOISTRA, Teake, HAVEKES, Louis M

“…Statins can exert anti-inflammatory antiatherosclerotic effects through an anti-inflammatory action, independent of lowering cholesterol. We addressed the…”
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Differential effects of pharmacological liver X receptor activation on hepatic and peripheral insulin sensitivity in lean and ob/ob mice by Grefhorst, Aldo, van Dijk, Theo H, Hammer, Anke, van der Sluijs, Fjodor H, Havinga, Rick, Havekes, Louis M, Romijn, Johannes A, Groot, Pieter H, Reijngoud, Dirk-Jan, Kuipers, Folkert

“…Liver X receptor (LXR) agonists have been proposed to act as anti-diabetic drugs. However, pharmacological LXR activation leads to severe hepatic steatosis, a…”
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The B domain of coagulation factor VIII interacts with the asialoglycoprotein receptor by BOVENSCHEN, N., RIJKEN, D. C., HAVEKES, L. M., VLIJMEN, B. J. M., MERTENS, K.

“…Background: Coagulation factor VIII (FVIII) is a heavily glycosylated heterodimeric plasma protein that consists of a heavy (domains A1‐A2‐B) and light chain…”
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CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice by Goudriaan, Jeltje R., Dahlmans, Vivian E.H., Teusink, Bas, Ouwens, D. Margriet, Febbraio, Maria, Maassen, J. Anton, Romijn, Johannes A., Havekes, Louis M., Voshol, Peter J.

“…CD36 (fatty acid translocase) is involved in high-affinity peripheral fatty acid uptake. Mice lacking CD36 exhibit increased plasma free fatty acid and…”
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Apolipoprotein C3 Deficiency Results in Diet-Induced Obesity and Aggravated Insulin Resistance in Mice by DUIVENVOORDEN, Ilse, TEUSINK, Bas, RENSEN, Patrick C, ROMIJN, Johannes A, HAVEKES, Louis M, VOSHOL, Peter J

“…Apolipoprotein C3 Deficiency Results in Diet-Induced Obesity and Aggravated Insulin Resistance in Mice Ilse Duivenvoorden 1 2 , Bas Teusink 1 , Patrick C…”
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Induction of atherosclerotic plaque rupture in apolipoprotein E-/- mice after adenovirus-mediated transfer of p53 by VON DER THÜSEN, Jan H, VAN VLIJMEN, Bart J. M, HOEBEN, Rob C, KOCKX, Mark M, HAVEKES, Louis M, VAN BERKEL, Theo J. C, BIESSEN, Erik A. L

“…The presence of the tumor-suppressor gene p53 in advanced atherosclerotic plaques and the sensitivity to p53-induced cell death of smooth muscle cells isolated…”
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Tumor necrosis factor-α promotes atherosclerotic lesion progression in APOE3-leiden transgenic mice by BOESTEN, Lianne S. M, ZADELAAR, A. Susanne M, VAN NIEUWKOOP, Anita, GIJBELS, Marion J. J, DE WINTHER, Menno P. J, HAVEKES, Louis M, VAN VLIJMEN, Bart J. M

“…Tumor necrosis factor-alpha (TNFalpha) is a pleiotropic cytokine exerting both inflammatory and cell death modulatory activity, and is thought to play a role…”
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PYY3–36 Reinforces Insulin Action on Glucose Disposal in Mice Fed a High-Fat Diet by VAN DEN HOEK, Anita M, HEOBOER, Annemieke C, CORSSMIT, Eleonora P. M, VOSHOL, Peter J, ROMIJN, Johannes A, HAVEKES, Louis M, PIJL, Hanno

“…PYY 3–36 Reinforces Insulin Action on Glucose Disposal in Mice Fed a High-Fat Diet Anita M. van den Hoek 1 2 , Annemieke C. Heijboer 1 3 , Eleonora P.M…”
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No Effect of C-Reactive Protein on Early Atherosclerosis Development in Apolipoprotein E3-Leiden/Human C-Reactive Protein Transgenic Mice by Trion, A, de Maat, M P.M, Jukema, J W, van der Laarse, A, Maas, M C, Offerman, E H, Havekes, L M, Szalai, A J, Princen, H M.G, Emeis, J J

“…OBJECTIVE—C-reactive protein (CRP) has been associated with risk of cardiovascular disease. It is not clear whether CRP is causally involved in the development…”
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Intracerebroventricular Neuropeptide Y Infusion Precludes Inhibition of Glucose and VLDL Production by Insulin by VAN DEN HOEK, Anita M, VOSHOL, Peter J, KARNEKAMP, Barbara N, BUIJS, Ruud M, ROMIJN, Johannes A, HAVEKES, Louis M, PIJL, Hanno

“…Intracerebroventricular Neuropeptide Y Infusion Precludes Inhibition of Glucose and VLDL Production by Insulin Anita M. van den Hoek 1 2 , Peter J. Voshol 1 3…”
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