Search Results - "Havekes, L. M."

Exendin‐4 decreases liver inflammation and atherosclerosis development simultaneously by reducing macrophage infiltration by Wang, Y, Parlevliet, E T, Geerling, J J, Tuin, S J L, Zhang, H, Bieghs, V, Jawad, A H M, Shiri‐Sverdlov, R, Bot, I, Jager, S C A, Havekes, L M, Romijn, J A, Willems van Dijk, K, Rensen, P C N

“…Background and Purpose The aetiology of inflammation in the liver and vessel wall, leading to non‐alcoholic steatohepatitis (NASH) and atherosclerosis,…”
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Hepatic Steatosis: A Mediator of the Metabolic Syndrome. Lessons From Animal Models by den Boer, M, Voshol, P.J, Kuipers, F, Havekes, L.M, Romijn, J.A

“…ABSTRACT—Epidemiological studies in humans, as well as experimental studies in animal models, have shown an association between visceral obesity and…”
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APOE3Leiden.CETP transgenic mice as model for pharmaceutical treatment of the metabolic syndrome by van den Hoek, A. M., van der Hoorn, J. W. A., Maas, A. C., van den Hoogen, R. M., van Nieuwkoop, A., Droog, S., Offerman, E. H., Pieterman, E. J., Havekes, L. M., Princen, H. M. G.

“…Aims This study aimed to investigate systematically (i) the appropriate dietary conditions to induce the features of the MetS in APOE*3Leiden.humanCholesteryl…”
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Ghrelin differentially affects hepatic and peripheral insulin sensitivity in mice by Heijboer, A. C, van den Hoek, A. M, Parlevliet, E. T, Havekes, L. M, Romijn, J. A, Pijl, H, Corssmit, E. P. M

“…Aims/hypothesis This study was conducted to evaluate the effects of ghrelin on insulin's capacity to suppress endogenous glucose production and promote glucose…”
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No Effect of C-Reactive Protein on Early Atherosclerosis Development in Apolipoprotein E3-Leiden/Human C-Reactive Protein Transgenic Mice by Trion, A, de Maat, M P.M, Jukema, J W, van der Laarse, A, Maas, M C, Offerman, E H, Havekes, L M, Szalai, A J, Princen, H M.G, Emeis, J J

“…OBJECTIVE—C-reactive protein (CRP) has been associated with risk of cardiovascular disease. It is not clear whether CRP is causally involved in the development…”
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Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and Type 2 diabetes susceptibility by Guigas, B., de Leeuw van Weenen, J. E., van Leeuwen, N., Simonis-Bik, A. M., van Haeften, T. W., Nijpels, G., Houwing-Duistermaat, J. J., Beekman, M., Deelen, J., Havekes, L. M., Penninx, B. W. J. H., Vogelzangs, N., van 't Riet, E., Dehghan, A., Hofman, A., Witteman, J. C., Uitterlinden, A. G., Grarup, N., Jørgensen, T., Witte, D. R., Lauritzen, T., Hansen, T., Pedersen, O., Hottenga, J., Romijn, J. A., Diamant, M., Kramer, M. H. H., Heine, R. J., Willemsen, G., Dekker, J. M., Eekhoff, E. M., Pijl, H., de Geus, E. J., Slagboom, P. E., 't Hart, L. M.

“…Aims Modulation of dopamine receptor D2 (DRD2) activity affects insulin secretion in both rodents and isolated pancreatic β‐cells. We hypothesized that single…”
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White Adipose Tissue: Getting Nervous by Fliers, E., Kreier, F., Voshol, P. J., Havekes, L. M., Sauerwein, H. P., Kalsbeek, A., Buijs, R. M., Romijn, J. A.

“…Neuroendocrine research has altered the traditional perspective of white adipose tissue (WAT) as a passive store of triglycerides. In addition to fatty acids,…”
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effect of dietary phytosphingosine on cholesterol levels and insulin sensitivity in subjects with the metabolic syndrome by Snel, M, Sleddering, M.A, Pijl, H, Nieuwenhuizen, W.F, Frolich, M, Havekes, L.M, Romijn, J.A, Jazet, I.M

“…Background: Sphingolipids, like phytosphingosine (PS) are part of cellular membranes of yeasts, vegetables and fruits. Addition of PS to the diet decreases…”
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Role of ApoCs in Lipoprotein Metabolism: Functional Differences Between ApoC1, ApoC2, and ApoC3 by Jong, Miek C, Hofker, Marten H, Havekes, Louis M

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Gut-Brain Axis: Regulation of Glucose Metabolism by Heijboer, A. C., Pijl, H., Van den Hoek, A. M., Havekes, L. M., Romijn, J. A., Corssmit, E. P. M.

“…Obesity and type II diabetes mellitus have reached epidemic proportions. From this perspective, knowledge about the regulation of satiety and food intake is…”
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Macrophage Low-Density Lipoprotein Receptor-Related Protein Deficiency Enhances Atherosclerosis in ApoE/LDLR Double Knockout Mice by Hu, L, Boesten, L S.M, May, P, Herz, J, Bovenschen, N, Huisman, M V, Berbée, J F.P, Havekes, L M, van Vlijmen, B J.M, Tamsma, J T

“…OBJECTIVE—In vitro studies implicate that the low-density lipoprotein receptor (LDLR)-related protein (LRP) in macrophages has a pro-atherogenic potential. In…”
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Intracerebroventricular administration of melanotan II increases insulin sensitivity of glucose disposal in mice by HEIJBOER, A. C, VAN DEN HOEK, A. M, FIJI, H, VOSHOL, P. J, HAVEKES, L. M, ROMIJN, J. A, CORSSMIT, E. P. M

“…The present study was conducted to evaluate the effects of central administration of melanotan II (MTII), a melanocortin-3/4 receptor agonist, on hepatic and…”
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The B domain of coagulation factor VIII interacts with the asialoglycoprotein receptor by BOVENSCHEN, N., RIJKEN, D. C., HAVEKES, L. M., VLIJMEN, B. J. M., MERTENS, K.

“…Background: Coagulation factor VIII (FVIII) is a heavily glycosylated heterodimeric plasma protein that consists of a heavy (domains A1‐A2‐B) and light chain…”
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Leptin Deficiency Per Se Dictates Body Composition and Insulin Action in ob/ob Mice by Van Den Hoek, A. M., Teusink, B., Voshol, P. J., Havekes, L. M., Romijn, J. A., Pijl, H.

“…Obese humans are often insulin‐ and leptin resistant. Since leptin can affect glucose metabolism, it is conceivable that a lack of leptin signal transduction…”
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Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice by KORSHENINNIKOVA, E, VAN DER ZON, G. C. M, MAASSEN, J. A, VOSHOL, P. J, JANSSEN, G. M, HAVEKES, L. M, GREFHORST, A, KUIPERS, F, REIJNGOUD, D.-J, ROMIJN, J. A, OUWENS, D. M

“…Activation of nutrient sensing through mammalian target of rapamycin (mTOR) has been linked to the pathogenesis of insulin resistance. We examined activation…”
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The dual PPARα/γ agonist tesaglitazar blocks progression of pre‐existing atherosclerosis in APOE3Leiden.CETP transgenic mice by Van Der Hoorn, JWA, Jukema, JW, Havekes, LM, Lundholm, E, Camejo, G, Rensen, PCN, Princen, HMG

“…Background and purpose:  We have evaluated the effects of a peroxisome proliferator‐activated receptor (PPAR)α/γ agonist on the progression of pre‐existing…”
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Apolipoprotein CI stimulates the response to lipopolysaccharide and reduces mortality in Gram-negative sepsis by Berbée, Jimmy F.P, Hoogt, Caroline C. van der, Kleemann, Robert, Schippers, Emile F, Kitchens, Richard L, Dissel, Jaap T. van, Bakker-Woudenberg, Irma A.J.M, Havekes, Louis M, Rensen, Patrick C.N

“…Gram-negative sepsis is a major death cause in intensive care units. Accumulating evidence indicates the protective role of plasma lipoproteins such as…”
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Macrophage Scavenger Receptor Class A: A Multifunctional Receptor in Atherosclerosis by de Winther, Menno P. J, van Dijk, Ko Willems, Havekes, Louis M, Hofker, Marten H

“…ABSTRACTIn atherogenesis, elevated plasma levels of low density lipoprotein (LDL) lead to the chronic presence of LDL in the arterial wall. There, LDL is…”
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Apolipoprotein E and carotid artery atherosclerosis: The Rotterdam study by SLOOTER, A. J. C, BOTS, M. L, HAVEKES, L. M, IGLESIAS DEL SOL, A, CRUTS, M, GROBBEE, D. E, HOFMAN, A, VAN BROECKHOVEN, C, WITTEMAN, J. C. M, VAN DUIJN, C. M

“…Carotid artery atherosclerosis is a strong predictor for future stroke. It is yet unclear whether the apolipoprotein E polymorphism (APOE) is related to…”
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Dietary vegetable oil and wood derived plant stanol esters reduce atherosclerotic lesion size and severity in apoE3-Leiden transgenic mice by Volger, O.L, Mensink, R.P, Plat, J, Hornstra, G, Havekes, L.M, Princen, H.M.G

“…The hypolipidemic and anti-atherosclerotic effects of vegetable oil- and wood-based dietary plant stanol esters were compared in female apoE*3-Leiden…”
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