Search Results - "Haut, Marc W."
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Developing, implementing, and evaluating the visiting Neighbors' program in rural Appalachia: A quality improvement protocol
Published in PloS one (02-01-2024)“…Older adults living alone in rural areas frequently experience health declines, social isolation, and limited access to services. To address these challenges,…”
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β-Amyloid Plaque Reduction in the Hippocampus After Focused Ultrasound-Induced Blood-Brain Barrier Opening in Alzheimer's Disease
Published in Frontiers in human neuroscience (07-10-2020)“…The blood-brain barrier (BBB) limits therapeutic delivery in Alzheimer's disease (AD) and other neurological disorders. Animal models have demonstrated safe…”
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Ultrasound-mediated blood-brain barrier opening uncovers an intracerebral perivenous fluid network in persons with Alzheimer's disease
Published in Fluids and barriers of the CNS (16-06-2023)“…Focused ultrasound (FUS)-mediated blood-brain barrier (BBB) opening is under investigation as a therapeutic modality for neurodegeneration, yet its effects in…”
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Deep Brain Stimulation of the Nucleus Accumbens/Ventral Capsule for Severe and Intractable Opioid and Benzodiazepine Use Disorder
Published in Experimental and clinical psychopharmacology (01-04-2021)“…Given high relapse rates and the prevalence of overdose deaths, novel treatments for substance use disorder (SUD) are desperately needed for those who are…”
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Demand on skillfulness modulates interhemispheric inhibition of motor cortices
Published in Journal of neurophysiology (01-06-2016)“…The role of primary motor cortex (M1) in the control of hand movements is still unclear. Functional magnetic resonance imaging (fMRI) studies of unimanual…”
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Low-intensity focused ultrasound targeting the nucleus accumbens as a potential treatment for substance use disorder: safety and feasibility clinical trial
Published in Frontiers in psychiatry (15-09-2023)“…Introduction While current treatments for substance use disorder (SUD) are beneficial, success rates remain low and treatment outcomes are complicated by…”
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Surface-based correlates of cognition along the Alzheimer's continuum in a memory clinic population
Published in Frontiers in neurology (05-09-2023)“…Composite cognitive measures in large-scale studies with biomarker data for amyloid and tau have been widely used to characterize Alzheimer's disease (AD)…”
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Evaluating the Abnormality of Bilateral Motor Cortex Activity in Subacute Stroke Patients Executing a Unimanual Motor Task With Increasing Demand on Precision
Published in Frontiers in neurology (25-05-2022)“…Abnormal contralesional M1 activity is consistently reported in patients with compromised upper limb and hand function after stroke. The underlying mechanisms…”
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Effects of monoaminergic drugs on training-induced motor cortex plasticity in older adults
Published in Brain research (01-09-2017)“…Highlights • In older subjects, training increased motor cortex excitability but not kinematics. • Carbi/levodopa increased motor cortex excitability while d-…”
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The Appalachia Mind Health Initiative (AMHI): a pragmatic randomized clinical trial of adjunctive internet-based cognitive behavior therapy for treating major depressive disorder among primary care patients
Published in Current controlled trials in cardiovascular medicine (20-06-2022)“…Major depressive disorder (MDD) is a leading cause of disease morbidity. Combined treatment with antidepressant medication (ADM) plus psychotherapy yields a…”
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Breastfeeding Duration Is Associated with Regional, but Not Global, Differences in White Matter Tracts
Published in Brain sciences (30-12-2019)“…Extended breastfeeding through infancy confers benefits on neurocognitive performance and intelligence tests, though few have examined the biological basis of…”
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Noninvasive hippocampal blood−brain barrier opening in Alzheimer’s disease with focused ultrasound
Published in Proceedings of the National Academy of Sciences - PNAS (28-04-2020)“…The blood–brain barrier (BBB) presents a significant challenge for treating brain disorders. The hippocampus is a key target for novel therapeutics, playing an…”
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Ultrasound Blood–Brain Barrier Opening and Aducanumab in Alzheimer’s Disease
Published in The New England journal of medicine (04-01-2024)“…Antiamyloid antibodies have been used to reduce cerebral amyloid-beta (Aβ) load in patients with Alzheimer’s disease. We applied focused ultrasound with each…”
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Blood-Brain Barrier Opening with MRI-guided Focused Ultrasound Elicits Meningeal Venous Permeability in Humans with Early Alzheimer Disease
Published in Radiology (01-03-2021)“…Background Opening of the blood-brain barrier (BBB) induced with MRI-guided focused ultrasound has been shown in experimental animal models to reduce amyloid-β…”
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Four single nucleotide polymorphisms in genes involved in neuronal signaling are associated with Opioid Use Disorder in West Virginia
Published in Journal of opioid management (01-03-2019)“…Pilot study to assess utility in opioid use disorder (OUD) of a panel of single nucleotide polymorphisms in genes previously related to substance use disorder…”
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White Matter Hyperintensity Burden and Disability in Older Adults: Is Chronic Pain a Contributor?
Published in PM & R (01-06-2013)“…Objective To primarily explore differences in global and regional white matter hyperintensities (WMH) in older adults with self-reported disabling and…”
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Focused ultrasound-mediated blood-brain barrier opening in Alzheimer's disease: long-term safety, imaging, and cognitive outcomes
Published in Journal of neurosurgery (01-07-2023)“…MRI-guided low-intensity focused ultrasound (FUS) has been shown to reversibly open the blood-brain barrier (BBB), with the potential to deliver therapeutic…”
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Gray matter volume of functionally relevant primary motor cortex is causally related to learning a hand motor task
Published in Cerebral cortex (New York, N.Y. 1991) (02-05-2024)“…Abstract Variability in brain structure is associated with the capacity for behavioral change. However, a causal link between specific brain areas and…”
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Focused Ultrasound for Neurodegenerative Diseases
Published in Magnetic resonance imaging clinics of North America (01-11-2024)“…Neurodegenerative diseases are a leading cause of death and disability and pose a looming global public health crisis. Despite progress in understanding…”
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