Search Results - "Hauswirth, W.W"

COMPARISON OF RAT RETINAL GANGLION CELLS TRANSDUCTION USING DIFFERENT HUMAN MINI-PROMOTERS COMPATIBLE WITH RAAV by Araújo, V.G., Dias, M.S., Hauswirth, W.W., Linden, R., Petrs-Silva, H.

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42 - COMPARISON OF RAT RETINAL GANGLION CELLS TRANSDUCTION USING DIFFERENT HUMAN MINI-PROMOTERS COMPATIBLE WITH RAAV by Araújo, V.G., Dias, M.S., Hauswirth, W.W., Linden, R., Petrs-Silva, H.

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COMPARISON OF RAT RETINAL GANGLION CELL TRANSDUCTION WITH DIFFERENT AMOUNT OF RAAV VECTOR by Rocha, T.N.S., Araújo, V.G., Hauswirth, W.W., Linden, R., Petrs-Silva, H.

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50 - COMPARISON OF RAT RETINAL GANGLION CELL TRANSDUCTION WITH DIFFERENT AMOUNT OF RAAV VECTOR by Rocha, T.N.S., Araújo, V.G., Hauswirth, W.W., Linden, R., Petrs-Silva, H.

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Modulation of the expression of the transcription factor Max in rat retinal ganglion cells by a recombinant adeno-associated viral vector by Petrs-Silva, H, Chiodo, V, Chiarini, L B, Hauswirth, W W, Linden, R

“…Exclusion of the transcription factor Max from the nucleus of retinal ganglion cells is an early, caspase-independent event of programmed cell death following…”
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Tyrosine capsid-mutant AAV vectors for gene delivery to the canine retina from a subretinal or intravitreal approach by Mowat, F M, Gornik, K R, Dinculescu, A, Boye, S L, Hauswirth, W W, Petersen-Jones, S M, Bartoe, J T

“…Recombinant adeno-associated viruses are important vectors for retinal gene delivery. Currently utilized vectors have relatively slow onset, and for efficient…”
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Retinal gene therapy with a large MYO7A cDNA using adeno-associated virus by Lopes, V S, Boye, S E, Louie, C M, Boye, S, Dyka, F, Chiodo, V, Fofo, H, Hauswirth, W W, Williams, D S

“…Usher 1 patients are born profoundly deaf and then develop retinal degeneration. Thus they are readily identified before the onset of retinal degeneration,…”
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Novel anti-VEGF chimeric molecules delivered by AAV vectors for inhibition of retinal neovascularization by Pechan, P, Rubin, H, Lukason, M, Ardinger, J, DuFresne, E, Hauswirth, W W, Wadsworth, S C, Scaria, A

“…Vascular endothelial growth factor (VEGF) is important in pathological neovascularization, which is a key component of diseases such as the wet form of…”
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Photoreceptor-targeted gene delivery using intravitreally administered AAV vectors in dogs by Boyd, R F, Sledge, D G, Boye, S L, Boye, S E, Hauswirth, W W, Komáromy, A M, Petersen-Jones, S M, Bartoe, J T

“…Delivery of therapeutic transgenes to retinal photoreceptors using adeno-associated virus (AAV) vectors has traditionally required subretinal injection…”
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Healthy and diseased corticospinal motor neurons are selectively transduced upon direct AAV2-2 injection into the motor cortex by Jara, J H, Stanford, M J, Zhu, Y, Tu, M, Hauswirth, W W, Bohn, M C, DeVries, S H, Özdinler, P H

“…Direct gene delivery to the neurons of interest, without affecting other neuron populations in the cerebral cortex, represent a challenge owing to the…”
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Reduced retinal transduction and enhanced transgene-directed immunogenicity with intravitreal delivery of rAAV following posterior vitrectomy in dogs by Boyd, R F, Boye, S L, Conlon, T J, Erger, K E, Sledge, D G, Langohr, I M, Hauswirth, W W, Komáromy, A M, Boye, S E, Petersen-Jones, S M, Bartoe, J T

“…Adeno-associated virus (AAV) vector-based gene therapy is a promising treatment strategy for delivery of neurotrophic transgenes to retinal ganglion cells…”
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Efficient cochlear gene transfection in guinea-pigs with adeno-associated viral vectors by partial digestion of round window membrane by Wang, H, Murphy, R, Taaffe, D, Yin, S, Xia, L, Hauswirth, W W, Bance, M, Robertson, G S, Wang, J

“…The auditory portion of the inner ear, the cochlea, is an ideal organ for local gene transfection owing to its relative isolation. Various carriers have been…”
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AAV8(Y733F)-mediated gene therapy in a Spata7 knockout mouse model of Leber congenital amaurosis and retinitis pigmentosa by Zhong, H, Eblimit, A, Moayedi, Y, Boye, S L, Chiodo, V A, Chen, Y, Li, Y, Nichols, R M, Hauswirth, W W, Chen, R, Mardon, G

“…Loss of SPATA7 function causes the pathogenesis of Leber congenital amaurosis and retinitis pigmentosa. Spata7 knockout mice mimic human SPATA7 –related…”
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Mitochondrial DNA copy number in bovine oocytes and somatic cells by Michaels, G.S., Hauswirth, W.W., Laipis, P.J.

“…Restriction endonuclease analysis and direct nucleotide sequencing of bovine mitochondrial DNA have revealed a high apparent rate of sequence divergence…”
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rAAV2 5 gene-targeting to rods:dose-dependent efficiency and complications associated with different promoters by Beltran, W A, Boye, S L, Boye, S E, Chiodo, V A, Lewin, A S, Hauswirth, W W, Aguirre, G D

“…A prerequisite for using corrective gene therapy to treat humans with inherited retinal degenerative diseases that primarily affect rods is to develop viral…”
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AAV-mediated and pharmacological induction of Hsp70 expression stimulates survival of retinal ganglion cells following axonal injury by Kwong, J M K, Gu, L, Nassiri, N, Bekerman, V, Kumar-Singh, R, Rhee, K D, Yang, X-J, Hauswirth, W W, Caprioli, J, Piri, N

“…We evaluated the effect of AAV2- and 17-AAG (17-N-allylamino-17-demethoxygeldanamycin)-mediated upregulation of Hsp70 expression on the survival of retinal…”
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Self-complementary AAV-mediated gene therapy restores cone function and prevents cone degeneration in two models of Rpe65 deficiency by Pang, J, Boye, S E, Lei, B, Boye, S L, Everhart, D, Ryals, R, Umino, Y, Rohrer, B, Alexander, J, Li, J, Dai, X, Li, Q, Chang, B, Barlow, R, Hauswirth, W W

“…To test whether fast-acting, self-complimentary (sc), adeno-associated virus-mediated RPE65 expression prevents cone degeneration and/or restores cone…”
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Preservation of photoreceptor morphology and function in P23H rats using an allele independent ribozyme by Gorbatyuk, M., Justilien, V., Liu, J., Hauswirth, W.W., Lewin, A.S.

“…To develop an allele independent ribozyme for the treatment of autosomal dominant retinitis pigmentosa (ADRP) associated with mutations in the rhodopsin ( RHO)…”
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Suppression of mouse rhodopsin expression in vivo by AAV mediated siRNA delivery by Gorbatyuk, M., Justilien, V., Liu, J., Hauswirth, W.W., Lewin, A.S.

“…The purpose of this study is to demonstrate that the expression of rhodopsin can be down regulated in vivo by AAV-delivered siRNA. This is the first step in an…”
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Heterogeneous mitochondrial DNA D-loop sequences in bovine tissue by Hauswirth, W W, Van de Walle, M J, Laipis, P J, Olivo, P D

“…Mitochondrial DNA from bovine tissue contains heterogeneous sequences located within an evolutionary conserved cytosine homopolymer sequence near the 5' end of…”
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