Obstetric outcomes in women with rheumatic disease and COVID-19 in the context of vaccination status

Abstract Objective To describe obstetric outcomes based on COVID-19 vaccination status, in women with rheumatic and musculoskeletal diseases (RMDs) who developed COVID-19 during pregnancy. Methods Data regarding pregnant women entered into the COVID-19 Global Rheumatology Alliance registry from 24 M...

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Published in:	Rheumatology (Oxford, England) Vol. 62; no. 4; pp. 1621 - 1626
Main Authors:	Maguire, Sinead, Al-Emadi, Samar, Alba, Paula, Aguiar, Mathia Cecilia, Al Lawati, Talal, Alle, Gelsomina, Bermas, Bonnie, Bhana, Suleman, Branimir, Anic, Bulina, Inita, Clowse, Megan, Cogo, Karina, Colunga, Iris, Cook, Claire, Cortez, Karen J, Dao, Kathryn, Gianfrancesco, Milena, Gore-Massey, Monique, Gossec, Laure, Grainger, Rebecca, Hausman, Jonathon, Hsu, Tiffany Y T, Hyrich, Kimme, Isnardi, Carolina, Kawano, Yumeko, Kilding, Rachael, Kusevich, Daria A, Lawson-Tovey, Saskia, Liew, Jean, McCarthy, Eoghan, Montgumery, Anna, Moyano, Sebastian, Nasir, Noreen, Padjen, Ivan, Papagoras, Charalampos, Patel, Naomi J, Pera, Mariana, Pisoni, Cecilia, Pons-Estel, Guillermo, Quiambao, Antonio L, Quintana, Rosana, Ruderman, Eric, Sattui, Sebastian, Savio, Veronica, Sciascia, Savino, Sencarova, Marieta, Morales, Rosa Serrano, Siddique, Faizah, Sirotich, Emily, Sparks, Jeffrey, Strangfeld, Anja, Sufka, Paul, Tanner, Helen, Tissera, Yohana, Wallace, Zachary, Werner, Marina L, Wise, Leanna, Worthing, Angus B, Zell, JoAnn, Zepa, Julija, Machado, Pedro M, Yazdany, Jinoos, Robinson, Philip, Conway, Richard
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 03-04-2023
Subjects:	Clinical Science COVID-19 - epidemiology COVID-19 - prevention & control COVID-19 Testing COVID-19 Vaccines Female Humans Infant, Newborn Pregnancy Premature Birth Rheumatic Diseases - drug therapy Vaccination COVID-19 patient outcomes women’s health rheumatic disease pregnancy vaccination
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Summary:	Abstract Objective To describe obstetric outcomes based on COVID-19 vaccination status, in women with rheumatic and musculoskeletal diseases (RMDs) who developed COVID-19 during pregnancy. Methods Data regarding pregnant women entered into the COVID-19 Global Rheumatology Alliance registry from 24 March 2020–25 February 2022 were analysed. Obstetric outcomes were stratified by number of COVID-19 vaccine doses received prior to COVID-19 infection in pregnancy. Descriptive differences between groups were tested using the chi-squared or Fisher’s exact test. Results There were 73 pregnancies in 73 women with RMD and COVID-19. Overall, 24.7% (18) of pregnancies were ongoing, while of the 55 completed pregnancies, 90.9% (50) of pregnancies resulted in livebirths. At the time of COVID-19 diagnosis, 60.3% (n = 44) of women were unvaccinated, 4.1% (n = 3) had received one vaccine dose while 35.6% (n = 26) had two or more doses. Although 83.6% (n = 61) of women required no treatment for COVID-19, 20.5% (n = 15) required hospital admission. COVID-19 resulted in delivery in 6.8% (n = 3) of unvaccinated women and 3.8% (n = 1) of fully vaccinated women. There was a greater number of preterm births (PTB) in unvaccinated women compared with fully vaccinated 29.5% (n = 13) vs 18.2% (n = 2). Conclusions In this descriptive study, unvaccinated pregnant women with RMD and COVID-19 had a greater number of PTB compared with those fully vaccinated against COVID-19. Additionally, the need for COVID-19 pharmacological treatment was uncommon in pregnant women with RMD regardless of vaccination status. These results support active promotion of COVID-19 vaccination in women with RMD who are pregnant or planning a pregnancy. Video Abstract 10.1093/rheumatology/keac534video1 Video Abstract A video abstract is available for this article and can be viewed at https://doi.org/10.1093/rheumatology/keac534. keac534media1 6313414140112
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1462-0324 1462-0332 1462-0332
DOI:	10.1093/rheumatology/keac534