Search Results - "Hauser, Stephen L."

B‐cell Therapy for Multiple Sclerosis: Entering an era by Greenfield, Ariele L., Hauser, Stephen L.

“…Monoclonal antibodies that target CD20 expressing B cells represent an important new treatment option for patients with multiple sclerosis (MS)…”
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Contribution of Relapse-Independent Progression vs Relapse-Associated Worsening to Overall Confirmed Disability Accumulation in Typical Relapsing Multiple Sclerosis in a Pooled Analysis of 2 Randomized Clinical Trials by Kappos, Ludwig, Wolinsky, Jerry S, Giovannoni, Gavin, Arnold, Douglas L, Wang, Qing, Bernasconi, Corrado, Model, Fabian, Koendgen, Harold, Manfrini, Marianna, Belachew, Shibeshih, Hauser, Stephen L

“…Accumulation of disability in multiple sclerosis may occur as relapse-associated worsening (RAW) or steady progression independent of relapse activity (PIRA),…”
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Chronic white matter lesion activity predicts clinical progression in primary progressive multiple sclerosis by Elliott, Colm, Belachew, Shibeshih, Wolinsky, Jerry S, Hauser, Stephen L, Kappos, Ludwig, Barkhof, Frederik, Bernasconi, Corrado, Fecker, Julian, Model, Fabian, Wei, Wei, Arnold, Douglas L

“…Chronic active and slowly expanding lesions with smouldering inflammation are neuropathological correlates of progressive multiple sclerosis pathology. T1…”
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Thalamic atrophy in multiple sclerosis: A magnetic resonance imaging marker of neurodegeneration throughout disease by Azevedo, Christina J., Cen, Steven Y., Khadka, Sankalpa, Liu, Shuang, Kornak, John, Shi, Yonggang, Zheng, Ling, Hauser, Stephen L., Pelletier, Daniel

“…Objective Thalamic volume is a candidate magnetic resonance imaging (MRI)‐based marker associated with neurodegeneration to hasten development of…”
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Multiple sclerosis: Prospects and promise by Hauser, Stephen L., Chan, Jonah R., Oksenberg, Jorge R.

“…We have entered a golden era in multiple sclerosis (MS) research. Two decades ago, our understanding of the disease was largely descriptive and there were no…”
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The Neurobiology of Multiple Sclerosis: Genes, Inflammation, and Neurodegeneration by Hauser, Stephen L., Oksenberg, Jorge R.

“…The autoimmune model of multiple sclerosis (MS) pathogenesis provided for many years a useful but incomplete conceptual framework for understanding the complex…”
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Ocrelizumab and Other CD20+ B-Cell-Depleting Therapies in Multiple Sclerosis by Gelfand, Jeffrey M., Cree, Bruce A. C., Hauser, Stephen L.

“…Selective depletion of CD20 + B cells by anti-CD20 monoclonal antibodies as monotherapy in multiple sclerosis (MS) profoundly suppresses acute inflammatory…”
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Silent progression in disease activity–free relapsing multiple sclerosis by Cree, Bruce A. C., Hollenbach, Jill A., Bove, Riley, Kirkish, Gina, Sacco, Simone, Caverzasi, Eduardo, Bischof, Antje, Gundel, Tristan, Zhu, Alyssa H., Papinutto, Nico, Stern, William A., Bevan, Carolyn, Romeo, Andrew, Goodin, Douglas S., Gelfand, Jeffrey M., Graves, Jennifer, Green, Ari J., Wilson, Michael R., Zamvil, Scott S., Zhao, Chao, Gomez, Refujia, Ragan, Nicholas R., Rush, Gillian Q., Barba, Patrick, Santaniello, Adam, Baranzini, Sergio E., Oksenberg, Jorge R., Henry, Roland G., Hauser, Stephen L.

“…Objective Rates of worsening and evolution to secondary progressive multiple sclerosis (MS) may be substantially lower in actively treated patients compared to…”
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The genetics of multiple sclerosis: an up-to-date review by Gourraud, Pierre-Antoine, Harbo, Hanne F., Hauser, Stephen L., Baranzini, Sergio E.

“…Multiple sclerosis (MS) is a prevalent inflammatory disease of the central nervous system that often leads to disability in young adults. Treatment options are…”
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Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis by Mei, Feng, Fancy, Stephen P J, Shen, Yun-An A, Niu, Jianqin, Zhao, Chao, Presley, Bryan, Miao, Edna, Lee, Seonok, Mayoral, Sonia R, Redmond, Stephanie A, Etxeberria, Ainhoa, Xiao, Lan, Franklin, Robin J M, Green, Ari, Hauser, Stephen L, Chan, Jonah R

“…High-throughput screening platform for the testing of small bioactive molecules that promote oligodendrocyte differentiation and remyelination: a new path to…”
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Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial by Kappos, Ludwig, Prof, Li, David, MD, Calabresi, Peter A, MD, O'Connor, Paul, MD, Bar-Or, Amit, MD, Barkhof, Frederik, Prof, Yin, Ming, PhD, Leppert, David, MD, Glanzman, Robert, MD, Tinbergen, Jeroen, MD, Hauser, Stephen L, Prof

“…Summary Background B lymphocytes are implicated in the pathogenesis of multiple sclerosis. We aimed to assess efficacy and safety of two dose regimens of the…”
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A pathogenic and clonally expanded B cell transcriptome in active multiple sclerosis by Ramesh, Akshaya, Schubert, Ryan D., Greenfield, Ariele L., Dandekar, Ravi, Loudermilk, Rita, Sabatino, Joseph J., Koelzer, Matthew T., Tran, Edwina B., Koshal, Kanishka, Kim, Kicheol, Pröbstel, Anne-Katrin, Banerji, Debarko, Guo, Chu-Yueh, Green, Ari J., Bove, Riley M., DeRisi, Joseph L., Gelfand, Jeffrey M., Cree, Bruce A. C., Zamvil, Scott S., Baranzini, Sergio E., Hauser, Stephen L., Wilson, Michael R.

“…Central nervous system B cells have several potential roles in multiple sclerosis (MS): secretors of proinflammatory cytokines and chemokines, presenters of…”
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Evaluation of no evidence of progression or active disease (NEPAD) in patients with primary progressive multiple sclerosis in the ORATORIO trial by Wolinsky, Jerry S., Montalban, Xavier, Hauser, Stephen L., Giovannoni, Gavin, Vermersch, Patrick, Bernasconi, Corrado, Deol‐Bhullar, Gurpreet, Garren, Hideki, Chin, Peter, Belachew, Shibeshih, Kappos, Ludwig

“…Objective No evidence of progression or active disease (NEPAD) is a novel combined endpoint defined by the absence of both progression and inflammatory disease…”
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The genetics of multiple sclerosis: SNPs to pathways to pathogenesis by Oksenberg, Jorge R, Hauser, Stephen L, Baranzini, Sergio E, Sawcer, Stephen

“…Key Points Multiple sclerosis (MS) clusters with the so-called complex genetic diseases, a group of common disorders characterized by modest disease-risk…”
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Genome-wide patterns of population structure and admixture in West Africans and African Americans by Bryc, Katarzyna, Auton, Adam, Nelson, Matthew R, Oksenberg, Jorge R, Hauser, Stephen L, Williams, Scott, Froment, Alain, Bodo, Jean-Marie, Wambebe, Charles, Tishkoff, Sarah A, Bustamante, Carlos D

“…Quantifying patterns of population structure in Africans and African Americans illuminates the history of human populations and is critical for undertaking…”
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Immunoglobulin class-switched B cells form an active immune axis between CNS and periphery in multiple sclerosis by Palanichamy, Arumugam, Apeltsin, Leonard, Kuo, Tracy C, Sirota, Marina, Wang, Shengzhi, Pitts, Steven J, Sundar, Purnima D, Telman, Dilduz, Zhao, Lora Z, Derstine, Mia, Abounasr, Aya, Hauser, Stephen L, von Büdingen, H-Christian

“…In multiple sclerosis (MS), lymphocyte--in particular B cell--transit between the central nervous system (CNS) and periphery may contribute to the maintenance…”
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Age, gender and normalization covariates for spinal cord gray matter and total cross-sectional areas at cervical and thoracic levels: A 2D phase sensitive inversion recovery imaging study by Papinutto, Nico, Schlaeger, Regina, Panara, Valentina, Zhu, Alyssa H, Caverzasi, Eduardo, Stern, William A, Hauser, Stephen L, Henry, Roland G

“…The source of inter-subject variability and the influence of age and gender on morphometric characteristics of the spinal cord, such as the total…”
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B cell exchange across the blood-brain barrier in multiple sclerosis by von Büdingen, H-Christian, Kuo, Tracy C, Sirota, Marina, van Belle, Christopher J, Apeltsin, Leonard, Glanville, Jacob, Cree, Bruce A, Gourraud, Pierre-Antoine, Schwartzburg, Amy, Huerta, Gabriella, Telman, Dilduz, Sundar, Purnima D, Casey, Tyler, Cox, David R, Hauser, Stephen L

“…In multiple sclerosis (MS) pathogenic B cells likely act on both sides of the blood-brain barrier (BBB). However, it is unclear whether antigen-experienced B…”
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Inflammatory and neurodegenerative serum protein biomarkers increase sensitivity to detect clinical and radiographic disease activity in multiple sclerosis by Chitnis, Tanuja, Qureshi, Ferhan, Gehman, Victor M., Becich, Michael, Bove, Riley, Cree, Bruce A. C., Gomez, Refujia, Hauser, Stephen L., Henry, Roland G., Katrib, Amal, Lokhande, Hrishikesh, Paul, Anu, Caillier, Stacy J., Santaniello, Adam, Sattarnezhad, Neda, Saxena, Shrishti, Weiner, Howard, Yano, Hajime, Baranzini, Sergio E.

“…The multifaceted nature of multiple sclerosis requires quantitative biomarkers that can provide insights related to diverse physiological pathways. To this…”
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Contribution of normal aging to brain atrophy in MS by Azevedo, Christina J, Cen, Steven Y, Jaberzadeh, Amir, Zheng, Ling, Hauser, Stephen L, Pelletier, Daniel

“…OBJECTIVETo identify the top brain regions affected by MS-specific atrophy (i.e., atrophy in excess of normal aging) and to test whether normal aging and…”
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