Search Results - "Hauser, David N"

Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism by Hauser, David N, Hastings, Teresa G

“…Abstract The pathogenic mechanisms that underlie Parkinson's disease remain unknown. Here, we review evidence from both sporadic and genetic forms of…”
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p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both by Narendra, Derek, Kane, Lesley A., Hauser, David N., Fearnley, Ian M., Youle, Richard J.

“…Mitochondria sustain damage with aging, and the resulting mitochondrial dysfunction has been implicated in a number of diseases including Parkinson disease. We…”
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The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation by Rudenko, Iakov N, Kaganovich, Alice, Hauser, David N, Beylina, Aleksandra, Chia, Ruth, Ding, Jinhui, Maric, Dragan, Jaffe, Howard, Cookson, Mark R

“…Autosomal-dominant missense mutations in LRRK2 (leucine-rich repeat kinase 2) are a common genetic cause of PD (Parkinson's disease). LRRK2 is a multidomain…”
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Dopamine quinone modifies and decreases the abundance of the mitochondrial selenoprotein glutathione peroxidase 4 by Hauser, David N, Dukes, April A, Mortimer, Amanda D, Hastings, Teresa G

“…Oxidative stress and mitochondrial dysfunction are known to contribute to the pathogenesis of Parkinson's disease. Dopaminergic neurons may be more sensitive…”
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Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice by Pellegrini, Laura, Hauser, David N, Li, Yan, Mamais, Adamantios, Beilina, Alexandra, Kumaran, Ravindran, Wetzel, Andrea, Nixon-Abell, Jonathon, Heaton, George, Rudenko, Iakov, Alkaslasi, Mor, Ivanina, Natalie, Melrose, Heather L, Cookson, Mark R, Harvey, Kirsten

“…Abstract Mutations in leucine-rich repeat kinase 2 (LRRK2) segregate with familial Parkinson's disease (PD) and genetic variation around LRRK2 contributes to…”
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The Effects of Variants in the Parkin, PINK1, and DJ-1 Genes along with Evidence for their Pathogenicity by Hauser, David N, Primiani, Christopher T, Cookson, Mark R

“…Early onset Parkinson's disease can be caused by variants in the PINK1, Parkin, and DJ-1 genes. Since their initial discoveries, hundreds of variants have been…”
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Hexokinases link DJ-1 to the PINK1/parkin pathway by Hauser, David N, Mamais, Adamantios, Conti, Melissa M, Primiani, Christopher T, Kumaran, Ravindran, Dillman, Allissa A, Langston, Rebekah G, Beilina, Alexandra, Garcia, Joseph H, Diaz-Ruiz, Alberto, Bernier, Michel, Fiesel, Fabienne C, Hou, Xu, Springer, Wolfdieter, Li, Yan, de Cabo, Rafael, Cookson, Mark R

“…Early onset Parkinson's disease is caused by variants in PINK1, parkin, and DJ-1. PINK1 and parkin operate in pathways that preserve mitochondrial integrity,…”
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Arsenite Stress Down-regulates Phosphorylation and 14-3-3 Binding of Leucine-rich Repeat Kinase 2 (LRRK2), Promoting Self-association and Cellular Redistribution by Mamais, Adamantios, Chia, Ruth, Beilina, Alexandra, Hauser, David N., Hall, Christine, Lewis, Patrick A., Cookson, Mark R., Bandopadhyay, Rina

“…Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) are a common genetic cause of Parkinson disease, but the mechanisms whereby LRRK2 is…”
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Longitudinal Characterization of Transcriptomic, Functional, and Morphological Features in Human iPSC-Derived Neurons and Their Application to Investigate Translational Progranulin Disease Biology by Robin, Gaëlle, Evans, J. Corey, Hauser, David N., Wren, Paul, Zembrzycki, Andreas

“…The disease biology of frontotemporal lobe dementia (FTD) is complex and not fully understood, with limited translational value appreciated from animal models…”
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Dopamine: Functions, Signaling, and Association with Neurological Diseases by Klein, Marianne O., Battagello, Daniella S., Cardoso, Ariel R., Hauser, David N., Bittencourt, Jackson C., Correa, Ricardo G.

“…The dopaminergic system plays important roles in neuromodulation, such as motor control, motivation, reward, cognitive function, maternal, and reproductive…”
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Post-translational decrease in respiratory chain proteins in the Polg mutator mouse brain by Hauser, David N, Dillman, Allissa A, Ding, Jinhui, Li, Yan, Cookson, Mark R

“…Mitochondrial DNA damage is thought to be a causal contributor to aging as mice with inactivating mutations in polymerase gamma (Polg) develop a progeroid…”
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Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease by Beilina, Alexandria, Rudenko, Iakov N., Kaganovich, Alice, Civiero, Laura, Chau, Hien, Kalia, Suneil K., Kalia, Lorraine V., Lobbestael, Evy, Chia, Ruth, Ndukwe, Kelechi, Ding, Jinhui, Nalls, Mike A., Olszewski, Maciej, Hauser, David N., Kumaran, Ravindran, Lozano, Andres M., Baekelandt, Veerle, Greene, Lois E., Taymans, Jean-Marc, Greggio, Elisa, Cookson, Mark R.

“…Mutations in leucine-rich repeat kinase 2 (LRRK2) cause inherited Parkinson disease (PD), and common variants around LRRK2 are a risk factor for sporadic PD…”
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mRNA expression, splicing and editing in the embryonic and adult mouse cerebral cortex by Dillman, Allissa A, Hauser, David N, Gibbs, J Raphael, Nalls, Michael A, McCoy, Melissa K, Rudenko, Iakov N, Galter, Dagmar, Cookson, Mark R

“…Using whole-transcriptome RNA sequencing at single-nucleotide resolution, this Resource article describes the mRNAs, RNA editing, splice variants and…”
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Differences in Stability, Activity and Mutation Effects Between Human and Mouse Leucine-Rich Repeat Kinase 2 by Langston, Rebekah G., Rudenko, Iakov N., Kumaran, Ravindran, Hauser, David N., Kaganovich, Alice, Ponce, Luis Bonet, Mamais, Adamantios, Ndukwe, Kelechi, Dillman, Allissa A., Al-Saif, Amr M., Beilina, Aleksandra, Cookson, Mark R.

“…Mutations in the Leucine-rich repeat kinase 2 ( LRRK2 ) gene have been implicated in the pathogenesis of Parkinson’s disease (PD). Identification of…”
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Use of cysteine‐reactive cross‐linkers to probe conformational flexibility of human DJ‐1 demonstrates that Glu18 mutations are dimers by Prahlad, Janani, Hauser, David N., Milkovic, Nicole M., Cookson, Mark R., Wilson, Mark A.

“…The oxidation of a key cysteine residue (Cys106) in the parkinsonism‐associated protein DJ‐1 regulates its ability to protect against oxidative stress and…”
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Astrocytes in Parkinson’s disease and DJ‐1 by Hauser, David N., Cookson, Mark R.

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The Polg Mutator Phenotype Does Not Cause Dopaminergic Neurodegeneration in DJ-1-Deficient Mice by Hauser, David N, Primiani, Christopher T, Langston, Rebekah G, Kumaran, Ravindran, Cookson, Mark R

“…Mutations in the DJ-1 gene cause autosomal recessive parkinsonism in humans. Several mouse models of DJ-1 deficiency have been developed, but they do not have…”
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Astrocytes in Parkinson’s disease and DJ-1: Review by Hauser, David N., Cookson, Mark R.

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Astrocytes in Parkinsonas disease and DJa1 by Hauser, David N, Cookson, Mark R

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Use of cysteine-reactive crosslinkers to probe conformational flexibility of human DJ-1 demonstrates that Glu18 mutations are dimers by Prahlad, Janani, Hauser, David N., Milkovic, Nicole M., Cookson, Mark R., Wilson, Mark A.

“…The oxidation of a key cysteine residue (Cys106) in the parkinsonism-associated protein DJ-1 regulates its ability to protect against oxidative stress and…”
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