Search Results - "Hauser, Carl"

Mitochondrial DAMPs increase endothelial permeability through neutrophil dependent and independent pathways by Sun, Shiqin, Sursal, Tolga, Adibnia, Yasaman, Zhao, Cong, Zheng, Yi, Li, Haipeng, Otterbein, Leo E, Hauser, Carl J, Itagaki, Kiyoshi

“…Trauma and sepsis can cause acute lung injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) in part by triggering neutrophil (PMN)-mediated increases in…”
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Circulating mitochondrial DAMPs cause inflammatory responses to injury by Zhang, Qin, Itagaki, Kiyoshi, Raoof, Mustafa, Sursal, Tolga, Sumi, Yuka, Junger, Wolfgang, Chen, Yu, Hauser, Carl J, Brohi, Karim

“…Injury causes a systemic inflammatory response syndrome (SIRS) that is clinically much like sepsis. Microbial pathogen-associated molecular patterns (PAMPs)…”
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Mitochondrial DNA released by trauma induces neutrophil extracellular traps by Itagaki, Kiyoshi, Kaczmarek, Elzbieta, Lee, Yen Ting, Tang, I Tien, Isal, Burak, Adibnia, Yashar, Sandler, Nicola, Grimm, Melissa J, Segal, Brahm H, Otterbein, Leo E, Hauser, Carl J

“…Neutrophil extracellular traps (NETs) are critical for anti-bacterial activity of the innate immune system. We have previously shown that mitochondrial…”
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Heme as a danger molecule in pathogen recognition by Wegiel, Barbara, Hauser, Carl J., Otterbein, Leo E.

“…Appropriate control of redox mechanisms are critical for and effective innate immune response, which employs multiple cell types, receptors and molecules that…”
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Ownership by Hauser, Carl J

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Role of Mitochondria-Derived Danger Signals Released After Injury in Systemic Inflammation and Sepsis by Itagaki, Kiyoshi, Riça, Ingred, Konecna, Barbora, Kim, Hyo In, Park, Jinbong, Kaczmarek, Elzbieta, Hauser, Carl J

“…Sepsis is a major public health concern, with high mortality and morbidity, especially among patients undergoing trauma. It is characterized by a systemic…”
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Carbon monoxide protects the kidney through the central circadian clock and CD39 by Correa-Costa, Matheus, Gallo, David, Csizmadia, Eva, Gomperts, Edward, Lieberum, Judith-Lisa, Hauser, Carl J., Ji, Xingyue, Wang, Binghe, Câmara, Niels Olsen Saraiva, Robson, Simon C., Otterbein, Leo E.

“…Ischemia reperfusion injury (IRI) is the predominant tissue insult associated with organ transplantation. Treatment with carbon monoxide (CO) modulates the…”
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Scavenging Circulating Mitochondrial DNA as a Potential Therapeutic Option for Multiple Organ Dysfunction in Trauma Hemorrhage by Aswani, Andrew, Manson, Joanna, Itagaki, Kiyoshi, Chiazza, Fausto, Collino, Massimo, Wupeng, Winston Liao, Chan, Tze Khee, Wong, W S Fred, Hauser, Carl J, Thiemermann, Chris, Brohi, Karim

“…Trauma is a leading cause of death worldwide with 5.8 million deaths occurring yearly. Almost 40% of trauma deaths are due to bleeding and occur in the first…”
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Monocyte exocytosis of mitochondrial danger-associated molecular patterns in sepsis suppresses neutrophil chemotaxis by Konecna, Barbora, Park, Jinbong, Kwon, Woon-Yong, Vlkova, Barbora, Zhang, Quanzhi, Huang, Wei, Kim, Hyo In, Yaffe, Michael B., Otterbein, Leo E., Itagaki, Kiyoshi, Hauser, Carl J.

“…Trauma and sepsis both increase the risk for secondary infections. Injury mobilizes mitochondrial (MT) danger-associated molecular patterns (mtDAMPs) directly…”
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Smart Generation and Transmission With Coherent, Real-Time Data by Bakken, David E., Bose, Anjan, Hauser, Carl H., Whitehead, David E., Zweigle, Gregary C.

“…In recent years, much of the discussion involving "smart grids" has implicitly involved only the distribution side, notably advanced metering. However, today's…”
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Use of power factor and specific point energy as design parameters in laser powder-bed-fusion (L-PBF) of AlSi10Mg alloy by Zavala-Arredondo, Miguel, London, Tyler, Allen, Madie, Maccio, Tomaso, Ward, Sam, Griffiths, David, Allison, Amanda, Goodwin, Paul, Hauser, Carl

“…The densification mechanism in L-PBF of AlSi10Mg alloy with varying process parameters has been investigated. The suitability of using volumetric [Jmm−3],…”
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Removal of circulating mitochondrial N-formyl peptides via immobilized antibody therapy restores sepsis-induced neutrophil dysfunction by Kwon, Woon Yong, Jung, Yoon Sun, Suh, Gil Joon, Kim, Sung Hee, Lee, Areum, Kim, Jeong Yeon, Kim, Hayoung, Park, Heesu, Shin, Jieun, Kim, Taegyun, Kim, Kyung Su, Itagaki, Kiyoshi, Hauser, Carl J

“…During recovery from septic shock, circulating mitochondrial N-formyl peptides (mtFPs) predispose to secondary infection by occupying formyl peptide receptor 1…”
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Extracellular mitochondria drive CD8 T cell dysfunction in trauma by upregulating CD39 by Tiwari-Heckler, Shilpa, Lee, Ghee Rye, Harbison, James, Ledderose, Carola, Csizmadia, Eva, Melton, David, Zhang, Quanzhi, Junger, Wolfgang, Chen, Guanqing, Hauser, Carl J, Otterbein, Leo E, Longhi, Maria Serena, Robson, Simon Christopher

“…The increased mortality and morbidity seen in critically injured patients appears associated with systemic inflammatory response syndrome (SIRS) and immune…”
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Security Implications of Transport Layer Protocols in Power Grid Synchrophasor Data Communication by Yujue Wang, Gamage, Thoshitha T., Hauser, Carl H.

“…Wide-area monitoring and control (WAMC) systems based on synchrophasor data streams are becoming more and more significant to the operation of the smart power…”
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Mitochondrial DNA is released by shock and activates neutrophils via p38 map kinase by Zhang, Qin, Itagaki, Kiyoshi, Hauser, Carl J

“…Bacterial DNA (bDNA) can activate an innate-immune stimulatory "danger" response via toll-like receptor 9 (TLR9). Mitochondrial DNA (mtDNA) is unique among…”
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Mitochondrial DAMPs Are Released During Cardiopulmonary Bypass Surgery and Are Associated With Postoperative Atrial Fibrillation by Sander, Nicola, MBBS, Kaczmarek, Elzbieta, PhD, Itagaki, Kiyoshi, PhD, Zheng, Yi, PhD, Otterbein, Leo, PhD, Khabbaz, Kamal, MD, Liu, David, MD, Senthilnathan, Venkatachalam, MD, Gruen, Russell L., MBBS, PhD, Hauser, Carl J., MD, FACS, FCCM

“…Background Atrial fibrillation (AF) is the most frequent complication of surgery performed on cardiopulmonary bypass (CPB) and recent work associates CPB with…”
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Plasma and wound fluids from trauma patients suppress neutrophil extracellular respiratory burst by Kim, Hyo In, Park, Jinbong, Konecna, Barbora, Huang, Wei, Riça, Ingred, Gallo, David, Otterbein, Leo E., Itagaki, Kiyoshi, Hauser, Carl J.

“…Trauma increases susceptibility to secondary bacterial infections. The events suppressing antimicrobial immunity are unclear. Polymorphonuclear neutrophils…”
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Health care and socioeconomic impact of falls in the elderly by Siracuse, Jeffrey J., M.D, Odell, David D., M.D, Gondek, Stephen P., M.D, Odom, Stephen R., M.D, Kasper, Ekkehard M., M.D, Hauser, Carl J., M.D, Moorman, Donald W., M.D

“…Abstract Background Elderly falls are associated with long hospital stays, major morbidity, and mortality. We sought to examine the fate of patients ≥75 years…”
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Circulating mitochondrial N-formyl peptides contribute to secondary nosocomial infection in patients with septic shock by Kwon, Woon Yong, Suh, Gil Joon, Jung, Yoon Sun, Park, Seung Min, Oh, Subi, Kim, Sung Hee, Lee, A. Rum, Kim, Jeong Yeon, Kim, Hayoung, Kim, Kyung Ah, Kim, Young, Kim, Byoung Choul, Kim, Taegyun, Kim, Kyung Su, Itagaki, Kiyoshi, Hauser, Carl J.

“…Secondary infections typically worsen outcomes of patients recovering from septic shock. Neutrophil [polymorphonuclear leukocytes (PMNs)] migration to…”
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DANGER Signals Activate G-Protein Receptor Kinases Suppressing Neutrophil Function and Predisposing to Infection After Tissue Trauma by Kim, Hyo In, Park, Jinbong, Gallo, David, Shankar, Sidharth, Konecna, Barbora, Han, Yohan, Banner-Goodspeed, Valerie, Capers, Krystal R., Ko, Seong-Gyu, Otterbein, Leo E., Itagaki, Kiyoshi, Hauser, Carl J.

“…Surgery injures tissue and predisposes to local and systemic infections. We studied injury-induced immune dysfunction seeking novel means to reverse such…”
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