Search Results - "Hauptschein, Robert"

Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma by Kan, Zhengyan, Zheng, Hancheng, Liu, Xiao, Li, Shuyu, Barber, Thomas D, Gong, Zhuolin, Gao, Huan, Hao, Ke, Willard, Melinda D, Xu, Jiangchun, Hauptschein, Robert, Rejto, Paul A, Fernandez, Julio, Wang, Guan, Zhang, Qinghui, Wang, Bo, Chen, Ronghua, Wang, Jian, Lee, Nikki P, Zhou, Wei, Lin, Zhao, Peng, Zhiyu, Yi, Kang, Chen, Shengpei, Li, Lin, Fan, Xiaomei, Yang, Jie, Ye, Rui, Ju, Jia, Wang, Kai, Estrella, Heather, Deng, Shibing, Wei, Ping, Qiu, Ming, Wulur, Isabella H, Liu, Jiangang, Ehsani, Mariam E, Zhang, Chunsheng, Loboda, Andrey, Sung, Wing Kin, Aggarwal, Amit, Poon, Ronnie T, Fan, Sheung Tat, Wang, Jun, Hardwick, James, Reinhard, Christoph, Dai, Hongyue, Li, Yingrui, Luk, John M, Mao, Mao

“…Hepatocellular carcinoma (HCC) is one of the most deadly cancers worldwide and has no effective treatment, yet the molecular basis of hepatocarcinogenesis…”
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Identification of CD44 as a surface biomarker for drug resistance by surface proteome signature technology by Cain, Jason W, Hauptschein, Robert S, Stewart, Jean K, Bagci, Tugba, Sahagian, Gary G, Jay, Daniel G

“…We developed surface proteome signatures (SPS) for identification of new biomarkers playing a role in cancer drug resistance. SPS compares surface antigen…”
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Functional proteomic screen identifies a modulating role for CD44 in death receptor-mediated apoptosis by HAUPTSCHEIN, Robert S, SLOAN, Kevin E, TORELLA, Claudia, MOEZZIFARD, Roya, GIEL-MOLONEY, Maryann, ZEHETMEIER, Carol, UNGER, Christine, ILAG, Leodevico L, JAY, Daniel G

“…Apoptotic evasion is a hallmark of cancer and its resistance to chemotherapeutic drugs. Identification of cellular proteins that mediate apoptotic programs is…”
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Abstract 6155: Lurbinectedin exhibits combinatorial activity with BCL2/BCL2L1 inhibitors in vitro and in vivo by modulation of MCL1 expression by Vaidya, Kedar S., Gupta, Aparna, Hauptschein, Robert, Humphreys, Robin C.

“…Abstract Lurbinectedin (Zepzelca) is a marine-derived anti-tumor agent currently approved for metastatic small cell lung cancer (SCLC). Lurbinectedin has been…”
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Global high-throughput screens for cellular function by Hauptschein, Robert S, Eustace, Brenda K, Jay, Daniel G

“…There is a critical need for global methods that allow for high-throughput assessment of cellular function for clinical and basic scientists working in both…”
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Abstract 2145: High SLFN11 expression correlates with sensitivity to lurbinectedin in small cell lung cancer (SCLC) models by Gupta, Aparna, Vaidya, Kedar S., Melis, Janneke J.T.M., Hauptschein, Robert, Brock, Graham, Humphreys, Robin

“…Abstract Background: Lurbinectedin monotherapy received accelerated FDA approval for adults with metastatic SCLC with disease progression on or after…”
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Novel phase 1a/1b dose-finding study design of CWP232291 (CWP291) in relapsed or refractory myeloma (MM) by Yoon, Sung-Soo, Manasanch, Elisabet Esteve, Min, Chang Ki, Kim, Jin Seok, Hauptschein, Robert S, Choi, Jeongeun, Chun, Jae Kwang

“…Abstract only TPS8058 Background: CWP291, a novel peptidomimetic small molecule, has potent, selective inhibitory activity on a Wnt gene reporter, decreasing…”
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Ongoing Phase 1a/1b Dose-Finding Study of CWP232291 (CWP291) in Relapsed or Refractory Multiple Myeloma (MM) by Yoon, Sung-Soo, Min, Chang-Ki, Kim, Jin Seok, Manasanch, Elisabet E., Hauptschein, Robert, Choi, Jeongeun, Lee, Kyoung-June

“…Background: CWP291, a novel peptidomimetic small molecule, has potent and selective inhibitory activity on a Wnt gene reporter and decreases expression of the…”
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Interim Results from the Phase 1a/1b Dose-Finding Study of CWP232291 (CWP291) in Relapsed or Refractory Myeloma (RRMM) Alone or in Combination with Lenalidomide and Dexamethasone by Manasanch, Elisabet E., Yoon, Sung-Soo, Min, Chang-Ki, Kim, Jin Seok, Shain, Kenneth H, Hauptschein, Robert, Choi, Jeongeun E, Lee, Kyoung-June

“…Background: CWP291, a novel peptidomimetic small molecule, has potent and selective inhibitory activity on a Wnt gene reporter and decreases expression of the…”
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Abstract 2677: JZP815, a potent and selective pan-RAF inhibitor, demonstrates efficacy in RAF and RAS mutant tumor pre-clinical models by Hauptschein, Robert, Woodcock, Simon, Belfield, Andrew, Mason, Helen, Keppel, Dorottya, Markova, Svetlana, Kim, Kyuri, Roller, Shane, Phillips, Caroline, Jones, Clifford D., Humphreys, Robin C.

“…Abstract Activation of the mitogen-activated protein kinase (MAPK) pathway by oncogenic mutations in RAS and RAF is a frequent driver of human cancer…”
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Phase 1 study of CWP232291 in relapsed/refractory acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) by Cortes, Jorge E., Faderl, Stefan, Pagel, John, Jung, Chul Won, Yoon, Sung-Soo, Koh, Youngil, Pardanani, Animesh Dev, Hauptschein, Robert S, Lee, Kyoung-June, Lee, Je-Hwan

“…Abstract only…”
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Abstract LB-229: Whole genome sequencing reveals genetic landscape of hepatocellular carcinoma by Mao, Mao, Zheng, Hancheng, Kan, Zhengyan, Xu, Jiangchun, Liu, Xiao, Li, Shuyu, Barber, Thomas, Gong, Zhuolin, Gao, Huan, Hao, Ke, Willard, Melinda, Hauptschein, Robert, Rejto, Paul, Fernandez, Julio, Wang, Guan, Zhang, Qinghui, Wang, Bo, Chen, Ronghua, Wang, Jian, Lee, Nikki, Zhou, Wei, Lin, Zhao, Peng, Zhiyu, Yi, Kang, Chen, Shengpei, Li, Lin, Fan, Xiaomei, Yang, Jie, Ye, Rui, Ju, Jia, Wang, Kai, Estrella, Heather, Deng, Shibing, Wei, Ping, Qiu, Ming, Wulur, Isabella, Liu, Jiangang, Ehsani, Mariam, Zhang, Chunsheng, Loboda, Andrey, Sung, Wing Kin, Aggarwal, Amit, Poon, Ronnie, Fan, Sheung Tat, Wang, Jun, Hardwick, James, Reinhard, Christoph, Dai, Hongyue, Li, Yingrui, Luk, John

“…Abstract Hepatocellular carcinoma (HCC) is one of the most deadly cancers worldwide and has no effective treatment, yet the molecular basis of…”
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Deletions involving two distinct regions of 6q in B-cell non-hodgkin lymphoma by GAIDANO, G, HAUPTSCHEIN, R. S, PARSA, N. Z, OFFIT, K, RAO, P. H, LENOIR, G, KNOWLES, D. M, CHAGANTI, R. S. K, DALLA-FAVERA, R

“…The recurrent loss of genetic material from a specific chromosomal region in a given tumor type suggests the presence of a tumor-suppressor gene, the loss or…”
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SEN6, a locus for SV40-mediated immortalization of human cells, maps to 6q26-27 by BANGA, S. S, KIM, S.-H, OZER, H. L, HUBBARD, K, DASGUPTA, T, JHA, K. K, PATSALIS, P, HAUPTSCHEIN, R, GAMBERI, B, DALLA-FAVERA, R, KRAEMER, P

“…Normal cells show a limited lifespan in culture and the phenotype of cellular senescence. Tumors and tumor cell lines have typically overcome this form of…”
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Cloning and Mapping of Human Chromosome 6q26–q27 Deleted in B-Cell Non-Hodgkin Lymphoma and Multiple Tumor Types by Hauptschein, Robert S., Gamberi, Barbara, Rao, Pulivarthi H., Frigeri, Ferdinando, Scotto, Luigi, Venkatraj, V.S., Gaidano, Gianluca, Rutner, Torin, Edwards, Yvonne H., Chaganti, R.S.K., Dalla-Favera, Riccardo

“…Frequent deletions of the distal region on the long arm of chromosome 6 have been reported in multiple human tumors including B-cell non-Hodgkin lymphoma…”
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Positional cloning studies of a tumor suppressor gene locus at human chromosome 6q26-q27 in B-cell non-Hodgkin's lymphoma by Hauptschein, Robert Scott

“…Previous cytogenetic studies of multiple human tumor types, including B-cell non-Hodgkin's lymphoma (B-NHL), have reported frequent deletions on the long arm…”
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An apparent interlocus gene conversion-like event at a putative tumor suppressor gene locus on human chromosome 6q27 in a Burkitt's lymphoma cell line by HAUPTSCHEIN, R. S, GAIDANO, G, RAO, P. H, SCOTTO, L, EDWARDS, Y. H, CHAGANTI, R. S. K, DALLA-FAVERA, R

“…A region of minimal deletion in B-cell non-Hodgkin's lymphoma (B-NHL) has recently been defined between D6S186 and D6S227 spanning 5-9 Mb at 6q26-q27,…”
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Cytogenetic and molecular analysis of 6q deletions in Burkitt's lymphoma cell lines by Parsa, N Z, Gaidano, G, Mukherjee, A B, Hauptschein, R S, Lenoir, G, Dalla-Favera, R, Chaganti, R S

“…Although abnormalities of chromosome 6 have frequently been observed in Burkitt's lymphoma (BL), they have so far not been defined by modern cytogenetic and…”
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Subregional localization of 20 single-copy loci to chromosome 6 by fluorescence in situ hybridization by Rao, P H, Murty, V V, Gaidano, G, Hauptschein, R, Dalla-Favera, R, Chaganti, R S

“…Although 338 genetic loci and 1 or more candidate tumor suppressor genes have been assigned to chromosome 6, the physical and genetic map of this chromosome is…”
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Pvull RFLP in the cytovillin gene (VIL2) on human chromosome 6q by Hauptschein, Robert, Dalla-Favera, Riccardo, Gaidano, Gianluca

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