Search Results - "Hauptmann, Astrid"

Scaling Down Large-Scale Thawing of Monoclonal Antibody Solutions: 3D Temperature Profiles, Changes in Concentration, and Density Gradients by Bluemel, Oliver, Buecheler, Jakob W., Hauptmann, Astrid, Hoelzl, Georg, Bechtold-Peters, Karoline, Friess, Wolfgang

“…Purpose Scale-down devices (SDD) are designed to simulate large-scale thawing of protein drug substance, but require only a fraction of the material. To…”
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The effect of mAb and excipient cryoconcentration on long-term frozen storage stability – part 2: Aggregate formation and oxidation by Bluemel, Oliver, Buecheler, Jakob W., Hauptmann, Astrid, Hoelzl, Georg, Bechtold-Peters, Karoline, Friess, Wolfgang

“…We examined the impact of monoclonal antibody (mAb) and buffer concentration, mimicking the cryoconcentration found upon freezing in a 2 L bottle, on mAb…”
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Genuine antiplasticizing effect of water on a glass-former drug by Ruiz, Guadalupe N., Romanini, Michela, Hauptmann, Astrid, Loerting, Thomas, Shalaev, Evgenyi, Tamarit, Josep Ll, Pardo, Luis C., Macovez, Roberto

“…Water is the most important plasticizer of biological and organic hydrophilic materials, which generally exhibit enhanced mechanical softness and molecular…”
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Optical cryomicroscopy and differential scanning calorimetry of buffer solutions containing cryoprotectants by Hauptmann, Astrid, Hoelzl, Georg, Loerting, Thomas

“…[Display omitted] In the pharmaceutical industry, cryoprotectants are added to buffer formulations to protect the active pharmaceutical ingredient from freeze-…”
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Distribution of Protein Content and Number of Aggregates in Monoclonal Antibody Formulation After Large-Scale Freezing by Hauptmann, Astrid, Hoelzl, Georg, Loerting, Thomas

“…Cryoconcentration of an in-house IgG 1 and number of aggregates in a formulation containing trehalose were determined in dependence on freezing protocol and…”
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Investigating freezing-induced acidity changes in citrate buffers by Susrisweta, Behera, Veselý, Lukáš, Štůsek, Radim, Hauptmann, Astrid, Loerting, Thomas, Heger, Dominik

“…[Display omitted] Citrate buffers are commonly utilized in the field of biomolecule stabilization. We investigate their applicability in the frozen state…”
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Raman Marker Bands for Secondary Structure Changes of Frozen Therapeutic Monoclonal Antibody Formulations During Thawing by Hauptmann, Astrid, Hoelzl, Georg, Mueller, Martin, Bechtold-Peters, Karoline, Loerting, Thomas

“…In this work we use Raman spectroscopy for protein characterization in the frozen state. We investigate the behavior of frozen therapeutic monoclonal antibody…”
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Impact of Buffer, Protein Concentration and Sucrose Addition on the Aggregation and Particle Formation during Freezing and Thawing by Hauptmann, Astrid, Podgoršek, Katja, Kuzman, Drago, Srčič, Stanko, Hoelzl, Georg, Loerting, Thomas

“…Purpose This study addresses the effect of freezing and thawing on a therapeutic monoclonal antibody (mAb) solution and the corresponding buffer formulation…”
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Distinct Speciation of Naphthalene Vapor Deposited on Ice Surfaces at 253 or 77 K: Formation of Submicrometer-Sized Crystals or an Amorphous Layer by Ondrušková, Gabriela, Krausko, Ján, Stern, Josef N, Hauptmann, Astrid, Loerting, Thomas, Heger, Dominik

“…Naphthalene was deposited from the vapor phase on ice surfaces at 77 or 253 K to yield strongly distinct behavior, forming either an amorphous glass layer or…”
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Correction to: Impact of Buffer, Protein Concentration and Sucrose Addition on the Aggregation and Particle Formation during Freezing and Thawing by Hauptmann, Astrid, Podgoršek, Katja, Kuzman, Drago, Srčič, Stanko, Hoelzl, Georg, Loerting, Thomas

“…The statement in the caption to Fig. 1 “ Data taken from reference (38).” ( Kolhe P, Holding E, Lary A, Chico S, Singh SK. Large-scale freezing of biologics:…”
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