Search Results - "Haukka, Jani K"

Whole-genome sequencing identifies variants in ANK1, LRRN1, HAS1, and other genes and regulatory regions for stroke in type 1 diabetes by Antikainen, Anni A., Haukka, Jani K., Kumar, Anmol, Syreeni, Anna, Hägg-Holmberg, Stefanie, Ylinen, Anni, Kilpeläinen, Elina, Kytölä, Anastasia, Palotie, Aarno, Putaala, Jukka, Thorn, Lena M., Harjutsalo, Valma, Groop, Per-Henrik, Sandholm, Niina

“…Individuals with type 1 diabetes (T1D) carry a markedly increased risk of stroke, with distinct clinical and neuroimaging characteristics as compared to those…”
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Confirmation of GLRA3 as a susceptibility locus for albuminuria in Finnish patients with type 1 diabetes by Sandholm, Niina, Haukka, Jani K, Toppila, Iiro, Valo, Erkka, Harjutsalo, Valma, Forsblom, Carol, Groop, Per-Henrik

“…Urinary albumin excretion is an early sign of diabetic kidney disease, affecting every third individual with diabetes. Despite substantial estimated…”
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Whole-exome sequencing identifies novel protein-altering variants associated with serum apolipoprotein and lipid concentrations by Sandholm, Niina, Hotakainen, Ronja, Haukka, Jani K, Jansson Sigfrids, Fanny, Dahlström, Emma H, Antikainen, Anni A, Valo, Erkka, Syreeni, Anna, Kilpeläinen, Elina, Kytölä, Anastasia, Palotie, Aarno, Harjutsalo, Valma, Forsblom, Carol, Groop, Per-Henrik

“…Dyslipidemia is a major risk factor for cardiovascular disease, and diabetes impacts the lipid metabolism through multiple pathways. In addition to the…”
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Differential metabolomic signatures of declining renal function in Types 1 and 2 diabetes by Manca, Maria Laura, Solini, Anna, Haukka, Jani K, Sandholm, Niina, Forsblom, Carol, Groop, Per-Henrik, Ferrannini, Ele

“…Abstract Background Chronic kidney disease (CKD) shows different clinical features in Types1 (T1D) and 2 diabetes (T2D). Metabolomics have recently provided…”
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Metabolomic Profile Predicts Development of Microalbuminuria in Individuals with Type 1 Diabetes by Haukka, Jani K., Sandholm, Niina, Forsblom, Carol, Cobb, Jeffrey E., Groop, Per-Henrik, Ferrannini, Ele

“…Elevated urinary albumin excretion (microalbuminuria) is an early marker of diabetic nephropathy, but there is an unmet need for better biomarkers that capture…”
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Whole-exome and whole-genome sequencing of 1064 individuals with type 1 diabetes reveals novel genes for diabetic kidney disease by Haukka, Jani K., Antikainen, Anni A., Valo, Erkka, Syreeni, Anna, Dahlström, Emma H., Lin, Bridget M., Franceschini, Nora, Krolewski, Andrzej S., Harjutsalo, Valma, Groop, Per-Henrik, Sandholm, Niina

“…Aims/hypothesis Diabetic kidney disease (DKD) is a severe diabetic complication that affects one third of individuals with type 1 diabetes. Although several…”
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Association of Coding Variants in Hydroxysteroid 17-beta Dehydrogenase 14 ( HSD17B14 ) with Reduced Progression to End Stage Kidney Disease in Type 1 Diabetes by Mychaleckyj, Josyf C, Valo, Erkka, Ichimura, Takaharu, Ahluwalia, Tarunveer S, Dina, Christian, Miller, Rachel G, Shabalin, Ivan G, Gyorgy, Beata, Cao, JingJing, Onengut-Gumuscu, Suna, Satake, Eiichiro, Smiles, Adam M, Haukka, Jani K, Tregouet, David-Alexandre, Costacou, Tina, O'Neil, Kristina, Paterson, Andrew D, Forsblom, Carol, Keenan, Hillary A, Pezzolesi, Marcus G, Pragnell, Marlon, Galecki, Andrzej, Rich, Stephen S, Sandholm, Niina, Klein, Ronald, Klein, Barbara E, Susztak, Katalin, Orchard, Trevor J, Korstanje, Ron, King, George L, Hadjadj, Samy, Rossing, Peter, Bonventre, Joseph V, Groop, Per-Henrik, Warram, James H, Krolewski, Andrzej S

“…Rare variants in gene coding regions likely have a greater impact on disease-related phenotypes than common variants through disruption of their encoded…”
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