Search Results - "Hauk, P J"

Induction of corticosteroid insensitivity in human PBMCs by microbial superantigens by Hauk, Pia J., Hamid, Qutayba A., Chrousos, George P., Leung, Donald Y.M.

“…Background: Microbial superantigens have been described to contribute to the pathogenesis of chronic inflammatory diseases often complicated by insensitivity…”
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Increased Glucocorticoid Receptor beta  in Airway Cells of Glucocorticoid-insensitive Asthma by HAMID, QUTAYBA A, WENZEL, SALLY E, HAUK, PIA J, TSICOPOULOS, ANNE, WALLAERT, BENOIT, LAFITTE, JEAN-JACQUES, CHROUSOS, GEORGE P, SZEFLER, STANLEY J, LEUNG, DONALD Y. M

“…Glucocorticoid (GC)-insensitive asthma is a challenging clinical problem that can be associated with life-threatening disease progression. The molecular basis…”
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Evidence for Superantigen Involvement in Skin Homing of T cells in Atopic Dermatitis by Strickland, Ian, Hauk, Pia J., Trumble, Anne E., Leung, Donald Y.M., Picker, Louis J.

“…The environmental factors that contribute to the homing of T cells in skin disease is unknown. The skin lesions of atopic dermatitis (AD) are frequently…”
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Tacrolimus (FK506): New treatment approach in superantigen-associated diseases like atopic dermatitis? by Hauk, Pia J., Leung, Donald Y.M.

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High constitutive glucocorticoid receptor beta in human neutrophils enables them to reduce their spontaneous rate of cell death in response to corticosteroids by Strickland, I, Kisich, K, Hauk, P J, Vottero, A, Chrousos, G P, Klemm, D J, Leung, D Y

“…Neutrophils are markedly less sensitive to glucocorticoids than T cells, making it difficult to control inflammation in neutrophil-mediated diseases…”
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Increased T-cell receptor V beta 8+ T cells in bronchoalveolar lavage fluid of subjects with poorly controlled asthma: A potential role for microbial superantigens by Hauk, P J, Wenzel, SE, Trumble, A E, Szefler, S J, Leung, DYM

“…T cells are thought to play an important role in the pathogenesis of chronic asthma. The immunologic triggers that contribute to poorly controlled asthma are…”
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Increased T-cell receptor Vβ8+ T cells in bronchoalveolar lavage fluid of subjects with poorly controlled asthma: A potential role for microbial superantigens by Hauk, Pia J., Wenzel, Sally E., Trumble, Anne E., Szefler, Stanley J., Leung, Donald Y.M.

“…Background: T cells are thought to play an important role in the pathogenesis of chronic asthma. The immunologic triggers that contribute to poorly controlled…”
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Increased T-cell receptor vbeta8+ T cells in bronchoalveolar lavage fluid of subjects with poorly controlled asthma: a potential role for microbial superantigens by Hauk, P J, Wenzel, S E, Trumble, A E, Szefler, S J, Leung, D Y

“…T cells are thought to play an important role in the pathogenesis of chronic asthma. The immunologic triggers that contribute to poorly controlled asthma are…”
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Bacteria in the Lower Airways of Children with Asthma, Chronic Cough and Wheezing by Hauk, P.J, Goleva, E, Jackson, L.P, Brugman, S.M, Krawiec, M.E, Leung, D.Y.M

“…To determine the pathogenic role of bacteria, we studied bronchoalveolar lavage (BAL) samples and the airway immune response in children with asthma, chronic…”
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Increased glucocorticoid receptor Beta expression converts mouse hybridoma cells to a corticosteroid-insensitive phenotype by Hauk, Pia J, Goleva, Elena, Strickland, Ian, Vottero, Alessandra, Chrousos, George P, Kisich, Kevin O, Leung, Donald Y M

“…Glucocorticoid (GC) insensitivity is a challenging clinical problem associated with many chronic inflammatory disorders and life-threatening disease…”
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Presence of Bacteria in the Lower Airways of Children with Chronic Cough and Wheezing by Hauk, P.J, Jackson, L.P, Krawiec, M.E, Brugman, S.M, Boguniewicz, J, Goleva, E, Leung, D.Y

“…To determine whether presence of bacteria in the lower airways plays a role in chronic cough and wheezing, we studied bronchoalveolar lavage (BAL) samples from…”
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Poorly Controlled Childhood Asthma Is Associated With Increased Bacterial Lipopolysaccharide (LPS) And Expression of Markers of Airway Remodeling In Bronchoalveolar Lavage (BAL) by Hauk, P.J, Krawiec, M, Boguniewicz, J, Schiltz, A.M, Goleva, E, Liu, A.H, Leung, D.Y.M

“…To determine whether LPS might play a role in childhood asthma, we studied bronchoalveolar lavage (BAL) fluid from children with poorly controlled asthma who…”
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Airway Remodeling and Lack of Bronchodilator Response in Steroid Resistant (SR) Asthma by Goleva, E, Hauk, P.J, Boguniewicz, J, Martin, R.J, Leung, D.Y.M

“…[...]TIMP-1 mRNA was induced in BAL cells from SS asthmatics after 4h of DEX treatment, but was unchanged in SR BAL cells…”
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Corticosteroid Resistant (CR) Asthma Is Associated with Classical Activation Of Airway Macrophages and Exposure To Lipopolysaccharide (LPS) by Hauk, P.J., Goleva, E., Liu, A.H., Hall, C.F., Riches, D.W.H., Martin, R.J., Leung, D.Y.M.

“…Microarray analyses of BAL cells from CR asthmatics showed significantly higher levels (p<0.05) of TNF-alpha (10.8-fold increase), IL1-alpha (8.5-fold…”
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Dog Ownership: A Risk Factor Of Corticosteroid-Resistant (CR) Asthma? by Hauk, P.J, Goleva, E, Liu, A.H, Hall, C.F, Martin, R.J, Leung, D.Y.M

“…Ten CR asthmatics had significantly higher amounts (p<0.01) of LPS in BAL fluid than 8 CS asthmatics (1444±457 pg versus 271±216 pg per mg/ml of total…”
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Bee-venom allergy in children: Long-term predictive value of standardized challenge tests by Schuetze, Georg E., Forster, Johannes, Hauk, Pia J., Friedl, Katrin, Kuehr, Joachim

“…Venom immunotherapy (VIT) is able to protect insect venom‐allergic patients against life‐threatening sting reactions. Standardized sting challenges can be used…”
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