Search Results - "Haughey, Norman"

Plasma ceramide and glucosylceramide metabolism is altered in sporadic Parkinson's disease and associated with cognitive impairment: a pilot study by Mielke, Michelle M, Maetzler, Walter, Haughey, Norman J, Bandaru, Veera V R, Savica, Rodolfo, Deuschle, Christian, Gasser, Thomas, Hauser, Ann-Kathrin, Gräber-Sultan, Susanne, Schleicher, Erwin, Berg, Daniela, Liepelt-Scarfone, Inga

“…Mutations in the gene coding for glucocerebrosidase (GBA), which metabolizes glucosylceramide (a monohexosylceramide) into glucose and ceramide, is the most…”
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Lipid accumulation and oxidation in glioblastoma multiforme by Taïb, Bouchra, Aboussalah, Amine M., Moniruzzaman, Mohammed, Chen, Suming, Haughey, Norman J., Kim, Sangwon F., Ahima, Rexford S.

“…Glioblastoma multiforme (GBM) is the most common and lethal primary malignant brain tumor in adults. Despite the multimodal standard treatments for GBM, the…”
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Stimulus‐dependent modifications in astrocyte‐derived extracellular vesicle cargo regulate neuronal excitability by Datta Chaudhuri, Amrita, Dasgheyb, Raha M., DeVine, Lauren R., Bi, Honghao, Cole, Robert N., Haughey, Norman J.

“…Extracellular vesicles have now emerged as key players in cell‐to‐cell communication. This is particularly important in the central nervous system, where…”
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Temporal changes in sphingolipids and systemic insulin sensitivity during the transition from gestation to lactation by Rico, J Eduardo, Saed Samii, Sina, Mathews, Alice T, Lovett, Jacqueline, Haughey, Norman J, McFadden, Joseph W

“…Reduced insulin action develops naturally during the peripartum to ensure maternal nutrient delivery to the fetus and neonate. However, increased insulin…”
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Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties by Figuera-Losada, Mariana, Stathis, Marigo, Dorskind, Joelle M, Thomas, Ajit G, Bandaru, Veera Venkata Ratnam, Yoo, Seung-Wan, Westwood, Nicholas J, Rogers, Graeme W, McArthur, Justin C, Haughey, Norman J, Slusher, Barbara S, Rojas, Camilo

“…Ceramide is a bioactive lipid that plays an important role in stress responses leading to apoptosis, cell growth arrest and differentiation. Ceramide…”
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HIV-associated neurocognitive disorder — pathogenesis and prospects for treatment by Saylor, Deanna, Dickens, Alex M., Sacktor, Ned, Haughey, Norman, Slusher, Barbara, Pletnikov, Mikhail, Mankowski, Joseph L., Brown, Amanda, Volsky, David J., McArthur, Justin C.

“…Key Points Despite entering the era of combination antiretroviral therapy (CART), HIV-associated neurocognitive disorder (HAND) remains prevalent; however,…”
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Involvement of organelles and inter-organellar signaling in the pathogenesis of HIV-1 associated neurocognitive disorder and Alzheimer’s disease by Khan, Nabab, Haughey, Norman J., Nath, Avindra, Geiger, Jonathan D.

“…•Endolysosomes physically and functionally interact with other organelles.•Alterations in endolysosome structure and function are implicated in HAND and AD.•A…”
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Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis by Haughey, Norman J., Bandaru, Veera V.R., Bae, Mihyun, Mattson, Mark P.

“…Sphingolipids in the membranes of neurons play important roles in signal transduction, either by modulating the localization and activation of…”
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Endolysosome involvement in HIV-1 transactivator protein-induced neuronal amyloid beta production by Chen, Xuesong, Hui, Liang, Geiger, Nicholas H, Haughey, Norman J, Geiger, Jonathan D

“…Abstract The increased life expectancy of people living with HIV-1/AIDS is accompanied by increased prevalence of HIV–1-associated neurocognitive disorder. As…”
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Chronic low-level expression of HIV-1 Tat promotes a neurodegenerative phenotype with aging by Dickens, Alex M., Yoo, Seung Wan, Chin, Alfred C., Xu, Jiadi, Johnson, Tory P., Trout, Amanda L., Hauser, Kurt F., Haughey, Norman J.

“…The widespread use of combinational antiretroviral therapies (cART) in developed countries has changed the course of Human Immunodeficiency Virus (HIV)…”
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Neuronal deletion of nSMase2 reduces the production of Aβ and directly protects neurons by Tohumeken, Sehmus, Deme, Pragney, Yoo, Seung Wan, Gupta, Sujasha, Rais, Rana, Slusher, Barbara S., Haughey, Norman J.

“…Extracellular vesicles (EVs) have been proposed to regulate the deposition of Aβ. Multiple publications have shown that APP, amyloid processing enzymes and Aβ…”
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TNFα and IL-1β modify the miRNA cargo of astrocyte shed extracellular vesicles to regulate neurotrophic signaling in neurons by Chaudhuri, Amrita Datta, Dastgheyb, Raha M., Yoo, Seung-Wan, Trout, Amanda, Talbot Jr, C. Conover, Hao, Haiping, Witwer, Kenneth W., Haughey, Norman J.

“…Astrocytes are known to be critical regulators of neuronal function. However, relatively few mediators of astrocyte to neuron communication have been…”
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Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis by Almad, Akshata A., Doreswamy, Arpitha, Gross, Sarah K., Richard, Jean-Philippe, Huo, Yuqing, Haughey, Norman, Maragakis, Nicholas J.

“…Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive loss of motor neurons in the CNS. Astrocytes play a critical…”
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Increasing fatty acid oxidation remodels the hypothalamic neurometabolome to mitigate stress and inflammation by McFadden, Joseph W, Aja, Susan, Li, Qun, Bandaru, Veera V R, Kim, Eun-Kyoung, Haughey, Norman J, Kuhajda, Francis P, Ronnett, Gabriele V

“…Modification of hypothalamic fatty acid (FA) metabolism can improve energy homeostasis and prevent hyperphagia and excessive weight gain in diet-induced…”
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Nipping disease in the bud: nSMase2 inhibitors as therapeutics in extracellular vesicle-mediated diseases by Tallon, Carolyn, Hollinger, Kristen R., Pal, Arindom, Bell, Benjamin J., Rais, Rana, Tsukamoto, Takashi, Witwer, Kenneth W., Haughey, Norman J., Slusher, Barbara S.

“…•Extracellular vesicles (EVs) are potent vehicles of intercellular communication.•EVs can transport pathological cargo that contributes to disease.•One pathway…”
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Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions by Dickens, Alex M, Tovar-Y-Romo, Luis B, Yoo, Seung-Wan, Trout, Amanda L, Bae, Mihyun, Kanmogne, Marlene, Megra, Bezawit, Williams, Dionna W, Witwer, Kennith W, Gacias, Mar, Tabatadze, Nino, Cole, Robert N, Casaccia, Patrizia, Berman, Joan W, Anthony, Daniel C, Haughey, Norman J

“…Brain injury induces a peripheral acute cytokine response that directs the transmigration of leukocytes into the brain. Because this brain-to-peripheral immune…”
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Intranasal insulin therapy reverses hippocampal dendritic injury and cognitive impairment in a model of HIV-associated neurocognitive disorders in EcoHIV-infected mice by Kim, Boe-Hyun, Kelschenbach, Jennifer, Borjabad, Alejandra, Hadas, Eran, He, Hongxia, Potash, Mary Jane, Nedelcovych, Michael T, Rais, Rana, Haughey, Norman J, McArthur, Justin C, Slusher, Barbara S, Volsky, David J

“…OBJECTIVE:Almost half of HIV-positive people on antiretroviral therapy have demonstrable mild neurocognitive impairment (HIV-NCI), even when virologically…”
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Monocarboxylate transporter 1 in Schwann cells contributes to maintenance of sensory nerve myelination during aging by Jha, Mithilesh Kumar, Lee, Youngjin, Russell, Katelyn A., Yang, Fang, Dastgheyb, Raha M., Deme, Pragney, Ament, Xanthe H., Chen, Weiran, Liu, Ying, Guan, Yun, Polydefkis, Michael J., Hoke, Ahmet, Haughey, Norman J., Rothstein, Jeffrey D., Morrison, Brett M.

“…Schwann cell (SC)‐specific monocarboxylate transporter 1 (MCT1) knockout mice were generated by mating MCT1 f/f mice with myelin protein zero (P0)‐Cre mice…”
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Neuroprotective effect of neuron‐specific deletion of the C16 ceramide synthetic enzymes in an animal model of multiple sclerosis by Amatruda, Mario, Marechal, Damien, Gacias, Mar, Wentling, Maureen, Turpin‐Nolan, Sarah, Morstein, Johannes, Moniruzzaman, Mohammed, Brüning, Jens C., Haughey, Norman J., Trauner, Dirk H., Casaccia, Patrizia

“…Abstract Ceramide C16 is a sphingolipid detected at high levels in several neurodegenerative disorders, including multiple sclerosis (MS). It can be generated…”
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Sphingolipids in Neurodegeneration by Haughey, Norman J.

“…Although the brain contains a high content of sphingolipids, we know relatively little about the roles that sphingolipids play in regulating neural functions…”
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