Search Results - "Hauge, Sissel"

Immunogenic cell death after combined treatment with radiation and ATR inhibitors is dually regulated by apoptotic caspases by Eek Mariampillai, Adrian, Hauge, Sissel, Kongsrud, Karoline, Syljuåsen, Randi G

“…Inhibitors of the ATR kinase act as radiosensitizers through abrogating the G2 checkpoint and reducing DNA repair. Recent studies suggest that ATR inhibitors…”
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Caspase activation counteracts interferon signaling after G2 checkpoint abrogation by ATR inhibition in irradiated human cancer cells by Eek Mariampillai, Adrian, Hauge, Sissel, Øynebråten, Inger, Rødland, Gro Elise, Corthay, Alexandre, Syljuåsen, Randi G.

“…Recent studies suggest that inhibition of the ATR kinase can potentiate radiation-induced antitumor immune responses, but the extent and mechanisms of such…”
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Potential Benefits of Combining Proton or Carbon Ion Therapy with DNA Damage Repair Inhibitors by Rødland, Gro Elise, Temelie, Mihaela, Eek Mariampillai, Adrian, Hauge, Sissel, Gilbert, Antoine, Chevalier, François, Savu, Diana I, Syljuåsen, Randi G

“…The use of charged particle radiotherapy is currently increasing, but combination therapy with DNA repair inhibitors remains to be exploited in the clinic. The…”
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p21 limits S phase DNA damage caused by the Wee1 inhibitor MK1775 by Hauge, Sissel, Macurek, Libor, Syljuåsen, Randi G.

“…The Wee1 inhibitor MK1775 (AZD1775) is currently being tested in clinical trials for cancer treatment. Here, we show that the p53 target and CDK inhibitor p21…”
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Expanding roles of cell cycle checkpoint inhibitors in radiation oncology by Hauge, Sissel, Eek Mariampillai, Adrian, Rødland, Gro Elise, Bay, Lilli T. E., Landsverk, Helga B., Syljuåsen, Randi G.

“…Radiation-induced activation of cell cycle checkpoints have been of long-standing interest. The WEE1, CHK1 and ATR kinases are key factors in cell cycle…”
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Combined inhibition of Wee1 and Chk1 gives synergistic DNA damage in S-phase due to distinct regulation of CDK activity and CDC45 loading by Hauge, Sissel, Naucke, Christian, Hasvold, Grete, Joel, Mrinal, Rødland, Gro Elise, Juzenas, Petras, Stokke, Trond, Syljuåsen, Randi G

“…Recent studies have shown synergistic cytotoxic effects of simultaneous Chk1- and Wee1-inhibition. However, the mechanisms behind this synergy are not known…”
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Differential Effects of Combined ATR/WEE1 Inhibition in Cancer Cells by Rødland, Gro Elise, Hauge, Sissel, Hasvold, Grete, Bay, Lilli T. E., Raabe, Tine T. H., Joel, Mrinal, Syljuåsen, Randi G.

“…Inhibitors of WEE1 and ATR kinases are considered promising for cancer treatment, either as monotherapy or in combination with chemo- or radiotherapy. Here, we…”
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Targeting lung cancer through inhibition of checkpoint kinases by Syljuåsen, Randi G, Hasvold, Grete, Hauge, Sissel, Helland, Åslaug

“…Inhibitors of checkpoint kinases ATR, Chk1, and Wee1 are currently being tested in preclinical and clinical trials. Here, we review the basic principles behind…”
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Hypoxia-induced alterations of G2 checkpoint regulators by Hasvold, Grete, Lund-Andersen, Christin, Lando, Malin, Patzke, Sebastian, Hauge, Sissel, Suo, ZhenHe, Lyng, Heidi, Syljuåsen, Randi G.

“…Hypoxia promotes an aggressive tumor phenotype with increased genomic instability, partially due to downregulation of DNA repair pathways. However, genome…”
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