Search Results - "Hauel, N"

Antithrombotic and anticoagulant effects of the direct thrombin inhibitor dabigatran, and its oral prodrug, dabigatran etexilate, in a rabbit model of venous thrombosis by WIENEN, W., STASSEN, J.‐M., PRIEPKE, H., RIES, U. J., HAUEL, N.

“…Background: Oral anticoagulant therapies targeted at thrombin are being developed to overcome limitations associated with current standard therapies…”
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288 EFFECT OF THE B1 ANTAGONIST BI 41488 IN DIFFERENT ANIMAL MODELS OF INFLAMMATORY PAIN by Ceci, A, Arndt, K, Hauel, N, Kauffmann-Hefner, I, Doods, H

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Pharmacological characterization of the novel nonpeptide angiotensin II receptor antagonist, BIBR 277 by Wienen, W., Hauel, N., Meel, J.C.A., Narr, B., Ries, U., Entzeroth, M.

“…1 The pharmacological profile of BIBR 277, 4′‐[(1,4′‐dimethyl‐2′‐propyl[2,6′‐bi‐1H‐benzimidazol]‐1′‐yl)methyl]‐[1,1′‐biphenyl]‐2‐carboxylic acid, a novel,…”
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6-Substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure-activity relationships by Ries, Uwe J, Mihm, Gerhard, Narr, Berthold, Hasselbach, Kai M, Wittneben, Helmut, Entzeroth, Michael, van Meel, Jacobus C. A, Wienen, Wolfgang, Hauel, Norbert H

“…Starting from the recently reported nonpeptidic angiotensin II (AII) receptor antagonists DuP753 (1) and Exp 7711 (2), we have designed and investigated novel…”
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Structural Basis for Inhibition Promiscuity of Dual Specific Thrombin and Factor Xa Blood Coagulation Inhibitors by Nar, Herbert, Bauer, Margit, Schmid, Angela, Stassen, Jean-Marie, Wienen, Wolfgang, Priepke, Henning W.M, Kauffmann, Iris K, Ries, Uwe J, Hauel, Norbert H

“…Background: A major current focus of pharmaceutical research is the development of selective inhibitors of the blood coagulation enzymes thrombin or factor Xa…”
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Effects of Telmisartan on Renal Excretory Function in Conscious Dogs by Schierok, H, Pairet, M, Hauel, N, Wienen, W

“…The present study investigated the effects of telmisartan, a selective AT1 receptor antagonist, on renal function in dogs. Conscious female dogs were treated…”
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A highly selective telomerase inhibitor limiting human cancer cell proliferation by Damm, Klaus, Hemmann, Ulrike, Garin-Chesa, Pilar, Hauel, Norbert, Kauffmann, Iris, Priepke, Henning, Niestroj, Claudia, Daiber, Christine, Enenkel, Barbara, Guilliard, Bernd, Lauritsch, Ines, Müller, Elfriede, Pascolo, Emanuelle, Sauter, Gabriele, Pantic, Milena, Martens, Uwe M., Wenz, Christian, Lingner, Joachim, Kraut, Norbert, Rettig, Wolfgang J., Schnapp, Andreas

“…Telomerase, the ribonucleoprotein enzyme maintaining the telomeres of eukaryotic chromosomes, is active in most human cancers and in germline cells but, with…”
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Mechanism of Human Telomerase Inhibition by BIBR1532, a Synthetic, Non-nucleosidic Drug Candidate by Pascolo, Emanuelle, Wenz, Christian, Lingner, Joachim, Hauel, Norbert, Priepke, Henning, Kauffmann, Iris, Garin-Chesa, Pilar, Rettig, Wolfgang J., Damm, Klaus, Schnapp, Andreas

“…Telomerase, a ribonucleoprotein acting as a reverse transcriptase, has been identified as a target for cancer drug discovery. The synthetic, non-nucleosidic…”
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Structure-Based Design of Novel Potent Nonpeptide Thrombin Inhibitors by Hauel, Norbert H, Nar, Herbert, Priepke, Henning, Ries, Uwe, Stassen, Jean-Marie, Wienen, Wolfgang

“…The clinical syndromes of thromboembolism are evoked by an excessive stimulation of the coagulation cascade. In this context, the serine protease thrombin…”
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Angiotensin II receptor antagonists by van Meel, J C, Entzeroth, M, Hauel, N, Narr, B, Ries, U, Wienen, W

“…The development of novel non-peptide compounds with high affinity for-angiotensin II (Ang II) receptors has greatly facilitated the subclassification of Ang II…”
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Heterocyclic thrombin inhibitors. Part 2: quinoxalinone derivatives as novel, potent antithrombotic agents by Ries, Uwe J., Priepke, Henning W.M., Hauel, Norbert H., Handschuh, Sandra, Mihm, Gerhard, Stassen, Jean M., Wienen, Wolfgang, Nar, Herbert

“…Quinoxalinone derivatives as prototypes of dual thrombin and factor Xa inhibitors have been discovered. Nanomolar inhibition of both coagulation enzymes…”
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Characterization of the nonpeptide angiotensin AT 1 receptor antagonist BIBR 363 by Entzeroth, M., Hauel, N., Diederen, W., Haigh, R., Wienen, W.

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Characterization of the nonpeptide angiotensin AT1 receptor antagonist BIBR 363 by Entzeroth, M., Hauel, N., Diederen, W., Haigh, R., Wienen, W.

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New cardiotonic agents--a promising approach for treatment of heart failure by Wetzel, B, Hauel, N

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Heterocyclic thrombin inhibitors. Part 1: design and synthesis of amidino-phenoxy quinoline derivatives by Ries, Uwe J., Priepke, Henning W.M., Hauel, Norbert H., Haaksma, Eric E.J., Stassen, Jean M., Wienen, Wolfgang, Nar, Herbert

“…Amidino-phenoxy quinoline derivatives represent a new class of potent thrombin inhibitors with good selectivity and remarkably low molecular weight ( M W:…”
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