Search Results - "Hauck, Ralf"

Further Branching of Valproate-Related Carboxylic Acids Reduces the Teratogenic Activity, but Not the Anticonvulsant Effect by Bojic, Ursula, Elmazar, Mohamed M. A, Hauck, Ralf-Siegbert, Nau, Heinz

“…In the present study, compounds derived from the anticonvulsant drug valproic acid (VPA, 2-n-propylpentanoic acid) and analogues known to be teratogenic were…”
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Educating Children for a Healthy Lifestyle by Münzel, Thomas, Münzel, Heidrun, Geipel, Peter, Mühl, Thorsten, Stoll, Heidi, Hammerschmidt, Rolf, Hauck, Ralf

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Asymmetric synthesis and enantioselective teratogenicity of 2-n-propyl-4-pentenoic acid (4-en-VPA), an active metabolite of the anticonvulsant drug, valproic acid by Hauck, R S, Nau, H

“…Previous studies indicated that the enantiomers of thalidomide and its analogue EM12 exhibit differing teratogenic potencies. Unfortunately, these substances…”
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Valproic acid-induced neural tube defects in mouse and human: aspects of chirality, alternative drug development, pharmacokinetics and possible mechanisms by Nau, H, Hauck, R S, Ehlers, K

“…Administration of the antiepileptic drug valproic acid (VPA) during early pregnancy can result in a 1-2% incidence of spina bifida aperta, a closure defect of…”
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The enantiomers of the valproic acid analogue 2-n-propyl-4-pentynoic acid (4-yn-VPA) : asymmetric synthesis and highly stereoselective teratogenicity in mice by HAUCK, R.-S, NAU, H

“…The teratogenic activities of R(+)- and S(-)-2-n-propyl-4-pentynoic acid (R and S-4-yn-VPA), the enantiomers of the highly teratogenic valproic acid (VPA)…”
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