Search Results - "Haubner, Jake"

Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases by Mukherjee, Sandip, Haubner, Jake, Chakraborty, Anutosh

“…In mammals, a family of three inositol hexakisphosphate kinases (IP6Ks) synthesizes the inositol pyrophosphate 5-IP7 from IP6. Genetic deletion of protects…”
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Whole Body Ip6k1 Deletion Protects Mice from Age-Induced Weight Gain, Insulin Resistance and Metabolic Dysfunction by Ghoshal, Sarbani, Mukherjee, Sandip, Chakraborty, Molee, Msengi, Eliwaza Naomi, Haubner, Jake, Chakraborty, Anutosh

“…(1) Background: We previously demonstrated that disruption of IP6K1 improves metabolism, protecting mice from high-fat diet-induced obesity, insulin…”
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The IP6K Inhibitor LI-2242 Ameliorates Diet-Induced Obesity, Hyperglycemia, and Hepatic Steatosis in Mice by Improving Cell Metabolism and Insulin Signaling by Mukherjee, Sandip, Chakraborty, Molee, Haubner, Jake, Ernst, Glen, DePasquale, Michael, Carpenter, Danielle, Barrow, James C, Chakraborty, Anutosh

“…Obesity and nonalcoholic fatty liver disease (NAFLD) are global health concerns, and thus, drugs for the long-term treatment of these diseases are urgently…”
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Pleiotropic actions of IP6K1 mediate hepatic metabolic dysfunction to promote nonalcoholic fatty liver disease and steatohepatitis by Mukherjee, Sandip, Chakraborty, Molee, Ulmasov, Barbara, McCommis, Kyle, Zhang, Jinsong, Carpenter, Danielle, Msengi, Eliwaza Naomi, Haubner, Jake, Guo, Chun, Pike, Daniel P., Ghoshal, Sarbani, Ford, David A., Neuschwander-Tetri, Brent A., Chakraborty, Anutosh

“…Obesity and insulin resistance greatly increase the risk of nonalcoholic fatty liver disease and steatohepatitis (NAFLD/NASH). We have previously discovered…”
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Ube4A maintains metabolic homeostasis and facilitates insulin signaling in vivo by Mukherjee, Sandip, Chakraborty, Molee, Msengi, Eliwaza N., Haubner, Jake, Zhang, Jinsong, Jellinek, Matthew J., Carlson, Haley L., Pyles, Kelly, Ulmasov, Barbara, Lutkewitte, Andrew J., Carpenter, Danielle, McCommis, Kyle S., Ford, David A., Finck, Brian N., Neuschwander-Tetri, Brent A., Chakraborty, Anutosh

“…Defining the regulators of cell metabolism and signaling is essential to design new therapeutic strategies in obesity and NAFLD/NASH. E3 ubiquitin ligases…”
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