Search Results - "Hau, Raymond K."

Addressing the Clinical Importance of Equilibrative Nucleoside Transporters in Drug Discovery and Development by Hau, Raymond K., Wright, Stephen H., Cherrington, Nathan J.

“…The US Food and Drug Administration (FDA), European Medicines Agency (EMA), and Pharmaceuticals and Medical Devices Agency (PMDA) guidances on small‐molecule…”
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PF‐07321332 (Nirmatrelvir) does not interact with human ENT1 or ENT2: Implications for COVID‐19 patients by Hau, Raymond K., Wright, Stephen H., Cherrington, Nathan J.

“…The ongoing pandemic of severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) and subsequently, coronavirus disease 2019 (COVID‐19), has led to the…”
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Generation of a hTERT-Immortalized Human Sertoli Cell Model to Study Transporter Dynamics at the Blood-Testis Barrier by Hau, Raymond K, Miller, Siennah R, Wright, Stephen H, Cherrington, Nathan J

“…The blood-testis barrier (BTB) formed by adjacent Sertoli cells (SCs) limits the entry of many chemicals into seminiferous tubules. Differences in rodent and…”
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Predicting disruptions to drug pharmacokinetics and the risk of adverse drug reactions in non-alcoholic steatohepatitis patients by Marie, Solène, Frost, Kayla L., Hau, Raymond K., Martinez-Guerrero, Lucy, Izu, Jailyn M., Myers, Cassandra M., Wright, Stephen H., Cherrington, Nathan J.

“…The liver plays a central role in the pharmacokinetics of drugs through drug metabolizing enzymes and transporters. Non-alcoholic steatohepatitis (NASH) causes…”
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Testicular disposition of clofarabine in rats is dependent on equilibrative nucleoside transporters by Miller, Siennah R., Jilek, Joseph L., McGrath, Meghan E., Hau, Raymond K., Jennings, Erin Q., Galligan, James J., Wright, Stephen H., Cherrington, Nathan J.

“…Acute lymphoblastic leukemia (ALL) is the most common cancer in children and adolescents. Although the 5‐year survival rate is high, some patients respond…”
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Drug Transporters at the Human Blood-Testis Barrier by Hau, Raymond K, Wright, Stephen H, Cherrington, Nathan J

“…Transporters are involved in the movement of many physiologically important molecules across cell membranes and have a substantial impact on the…”
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In Vitro and In Vivo Models for Drug Transport Across the Blood-Testis Barrier by Hau, Raymond K, Wright, Stephen H, Cherrington, Nathan J

“…The blood-testis barrier (BTB) is a selectively permeable membrane barrier formed by adjacent Sertoli cells (SCs) in the seminiferous tubules of the testes…”
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Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier by Hau, Raymond K, Klein, Robert R, Wright, Stephen H, Cherrington, Nathan J

“…The blood-testis barrier (BTB) is formed by basal tight junctions between adjacent Sertoli cells (SCs) of the seminiferous tubules and acts as a physical…”
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Implications of Species Differences in Function and Localization of Transporters at the Blood-Testis Barrier by Hau, Raymond K, Miller, Siennah R, Cherrington, Nathan J

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Physiological Characterization of the Transporter-Mediated Uptake of the Reversible Male Contraceptive H2-Gamendazole Across the Blood-Testis Barrier by Hau, Raymond K, Tash, Joseph S, Georg, Gunda I, Wright, Stephen H, Cherrington, Nathan J

“…The blood-testis barrier (BTB) is formed by a tight network of Sertoli cells (SCs) to limit the movement of reproductive toxicants from the blood into the male…”
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Nucleoside Reverse Transcriptase Inhibitor (NRTI) Interaction with Human Equilibrative Nucleoside Transporters 1 and 2 by Miller, Siennah R, Hau, Raymond K, Jilek, Joseph L, Morales, Mark N, Wright, Stephen H, Cherrington, Nathan J

“…Equilibrative nucleoside transporters (ENTs) transport nucleosides across the blood-testis barrier (BTB). ENTs are of interest to study the disposition of…”
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Predicting Drug Interactions with Human Equilibrative Nucleoside Transporters 1 and 2 Using Functional Knockout Cell Lines and Bayesian Modeling by Miller, Siennah R, Zhang, Xiaohong, Hau, Raymond K, Jilek, Joseph L, Jennings, Erin Q, Galligan, James J, Foil, Daniel H, Zorn, Kimberley M, Ekins, Sean, Wright, Stephen H, Cherrington, Nathan J

“…Equilibrative nucleoside transporters (ENTs) 1 and 2 facilitate nucleoside transport across the blood-testis barrier (BTB). Improving drug entry into the…”
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Transporter Inhibition Profile for the Antivirals Tilorone, Quinacrine and Pyronaridine by Vignaux, Patricia A., Lane, Thomas R., Puhl, Ana C., Hau, Raymond K., Wright, Stephen H., Cherrington, Nathan J., Ekins, Sean

“…Pyronaridine, tilorone and quinacrine are cationic molecules that have in vitro activity against Ebola, SARS-CoV-2 and other viruses. All three molecules have…”
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ToxPoint: Implications of Species Differences in Function and Localization of Transporters at the Blood–Testis Barrier by Hau, Raymond K, Miller, Siennah R, Cherrington, Nathan J

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Modeling Blood‐Testis Barrier Characteristics with Novel CRISPR/Cas9 Functional ENT1 and ENT2 Knockout HeLa Cell Lines by Miller, Siennah R., Zhang, Xiaohong Rebecca, Hau, Raymond K., Jennings, Erin Q., Galligan, James J., Wright, Stephen H., Cherrington, Nathan J.

“…Abstract only…”
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