Search Results - "Hatzis, C."

Immunological differences between primary and metastatic breast cancer by Szekely, B., Bossuyt, V., Li, X., Wali, V.B., Patwardhan, G.A., Frederick, C., Silber, A., Park, T., Harigopal, M., Pelekanou, V., Zhang, M., Yan, Q., Rimm, D.L., Bianchini, G., Hatzis, C., Pusztai, L.

“…Little is known about how the immune microenvironment of breast cancer evolves during disease progression. We compared tumor infiltrating lymphocyte (TIL)…”
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Pathway level alterations rather than mutations in single genes predict response to HER2-targeted therapies in the neo-ALTTO trial by Shi, W., Jiang, T., Nuciforo, P., Hatzis, C., Holmes, E., Harbeck, N., Sotiriou, C., Peña, L., Loi, S., Rosa, D.D., Chia, S., Wardley, A., Ueno, T., Rossari, J., Eidtmann, H., Armour, A., Piccart-Gebhart, M., Rimm, D.L., Baselga, J., Pusztai, L.

“…We performed whole-exome sequencing of pretreatment biopsies and examined whether genome-wide metrics of overall mutational load, clonal heterogeneity or…”
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Is complete response the answer? by Pusztai, L., Szekely, B., Hatzis, C.

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Pathway level alterations rather than mutations in single genes predict response to HER2-targeted therapies in the neo-ALTTO trial by Shi, W, Jiang, T, Nuciforo, P, Hatzis, C, Holmes, E, Harbeck, N, Sotiriou, C, Peña, L, Loi, S, Rosa, D D, Chia, S, Wardley, A, Ueno, T, Rossari, J, Eidtmann, H, Armour, A, Piccart-Gebhart, M, Rimm, D L, Baselga, J, Pusztai, L

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Pathway level alterations rather than mutations in single genes predict response to HER2-targeted therapies in the neo-ALTTO trial by Shi, W, Jiang, T, Nuciforo, P, Hatzis, C, Holmes, E, Harbeck, N, Sotiriou, C, Peña, L, Loi, S, Rosa, D D, Chia, S, Wardley, A, Ueno, T, Rossari, J, Eidtmann, H, Armour, A, Piccart-Gebhart, M, Rimm, D L, Baselga, J, Pusztai, L

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Metabolic isoenzyme shifts in cancer as potential novel therapeutic targets by Ononye, S. N., Shi, W., Wali, V. B., Aktas, B., Jiang, T., Hatzis, C., Pusztai, L.

“…The functional redundancy of metabolic enzyme expression may present a new strategy for developing targeted therapies in cancer. To satisfy the increased…”
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Depression and long chain n-3 fatty acids in adipose tissue in adults from Crete by Mamalakis, G, Kalogeropoulos, N, Andrikopoulos, N, Hatzis, C, Kromhout, D, Moschandreas, J, Kafatos, A

“…Background: Only one study has investigated the relationship of essential fatty acids in the adipose tissue with depression in adults and suggested an inverse…”
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Hormone receptor status and pathologic response of HER2-positive breast cancer treated with neoadjuvant chemotherapy and trastuzumab by Peintinger, F., Buzdar, A. U., Kuerer, H. M., Mejia, J. A., Hatzis, C., Gonzalez-Angulo, A. M., Pusztai, L., Esteva, F. J., Dawood, S. S., Green, M. C., Hortobagyi, G. N., Symmans, W. F.

“…Background: The aim of this study was to compare the extent of pathologic response in patients with HER2-positive (HER2+) breast cancer treated with standard…”
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Prevalence and independent predictors of insulin resistance in children from Crete, Greece: The Children Study by Manios, Y., Moschonis, G., Kourlaba, G., Bouloubasi, Z., Grammatikaki, E., Spyridaki, A., Hatzis, C., Kafatos, A., Fragiadakis, G. A.

“…Background  It has been proposed that insulin resistance (IR) is associated with the development of Type 2 diabetes mellitus and cardiovascular disease. The…”
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Efficacy and tolerability of combination cisplatin and ifosfamide chemotherapy with vaginal cuff brachytherapy in the first line treatment of uterine carcinosarcoma by Abu-Khalaf, M M, Raza, M A, Hatzis, C, Wang, H, Lin, K, Higgins, S, Ratner, E, Silasi, D A, Azodi, M, Rutherford, T J, Santin, A Dd, Schwartz, P Ee

“…A retrospective study to evaluate six cycles of cisplatin 40 mg/m2 on day 1 and ifosfamide 1,200 mg/m2 daily on days 1 to 4 with Mesna every four weeks as…”
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Depression and serum adiponectin and adipose omega-3 and omega-6 fatty acids in adolescents by Mamalakis, George, Kiriakakis, Michael, Tsibinos, George, Hatzis, Christos, Flouri, Sofia, Mantzoros, Christos, Kafatos, Anthony

“…The purpose of the present study was to investigate for a possible relationship between depression and serum adiponectin and adipose tissue omega-3 and omega-6…”
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Prevalence of obesity and physical inactivity among farmers from Crete (Greece), four decades after the seven countries study by Vardavas, C.I, Linardakis, M.K, Hatzis, C.M, Saris, W.H.M, Kafatos, A.G

“…Abstract Background and aim As first shown 40 years ago farmers from Crete had one of the healthiest lifestyles compared to other participants of the Seven…”
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Adipose tissue fatty acids in breast cancer patients versus healthy control women from Crete by Mamalakis, G, Hatzis, C, de Bree, E, Sanidas, E, Tsiftsis, D D, Askoxylakis, J, Daskalakis, M, Tsibinos, G, Kafatos, A

“…Few studies have implemented biomarkers of fatty acid intake in relation to breast cancer. To examine possible differences in adipose tissue fatty acid…”
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Brief Report: A Prospective Open‐Label Phase IIa Trial of Tocilizumab in the Treatment of Polymyalgia Rheumatica by Lally, Lindsay, Forbess, Lindsy, Hatzis, Christopher, Spiera, Robert

“…Objective Interleukin‐6 (IL‐6) is a pivotal cytokine in the pathogenesis of polymyalgia rheumatica (PMR), yet the efficacy of IL‐6 blockade with tocilizumab…”
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Abstract P3-05-01: Age-related methylation signals of breast cancer risk in blood by Hofstatter, EW, Levine, M, Hatzis, C, Pusztai, L

“…Abstract BACKGROUND: Age is the biggest risk factor for developing breast cancer, which suggests that the biological aging process is a direct driver of cancer…”
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Differences in postprandial lipaemic response between Northern and Southern Europeans by Zampelas, A, Roche, H, Knapper, J.M.E, Jackson, K.G, Tornaritis, M, Hatzis, C, Gibney, M.J, Kafatos, A, Gould, B.J, Wright, J, Williams, C.M

“…Postprandial lipaemic responses to two test meals were investigated in 30 Northern (15 British and 15 Irish), and 30 Southern (Greeks from Crete) healthy male…”
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Abstract P1-07-10: Molecular subtypes of triple negative breast cancer have different sensitivity signature to established chemotherapy agents by Győrffy, B, Nagy, Á, Santarpia, L, Hatzis, C

“…Abstract Background: Triple negative breast cancer (TNBC, ER/PR/HER2 negative) patients have the worst prognosis among all breast cancer patients. Recently,…”
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Biochemical engineering analysis of critical process factors in the biomass-to-ethanol technology by Philippidis, G.P. (Thermo Fibergen Inc., Bedford, MA.), Hatzis, C

“…Ethanol from cellulosic biomass is a promising renewable liquid transportation fuel. Applied research in the area of biomass conversion to ethanol in the last…”
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Abstract P4-03-01: Pathway level complementarity of germline and somatic events in breast cancer by Qing, T, Marczyk, M, Wali, V, Gunasekharan, V, Patwardhan, G, Pusztai, L, Hatzis, C

“…Abstract Background: Progression from a normal cell state to cancer requires multiple genomic hits in key regulatory pathways. In the case of hereditary cancer…”
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783TiP Phase I study of HFB301001, a novel OX40 agonist monoclonal antibody, in patients with solid tumors selected via Drug Intelligence Science (DIS) by Spira, A., Mehra, R., Mantia, C., Babiker, H., Borad, M., Cervantes, A., Garralda, E., Mahipal, A., Paz-Ares, L., Hatzis, C., Liu, A., Raue, A., Gan, J., Adrian, F., Manenti, L., El-Khoueiry, A.B.

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