Search Results - "Hattori, Fumiyuki"

Lgr6-expressing functional nail stem-like cells differentiated from human-induced pluripotent stem cells by Inomata, Yukino, Kawatani, Nano, Yamashita, Hiromi, Hattori, Fumiyuki

“…The nail matrix containing stem cell populations produces nails and may contribute to fingertip regeneration. Nails are important tissues that maintain the…”
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Machine learning discriminates P2X7-mediated intracellular calcium sparks in human-induced pluripotent stem cell-derived neural stem cells by Hanafusa, Yuki, Shiraishi, Akira, Hattori, Fumiyuki

“…Adenosine triphosphate (ATP) is an extracellular signaling molecule that mainly affects the pathophysiological situation in the body and can be sensed by…”
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Distinct Metabolic Flow Enables Large-Scale Purification of Mouse and Human Pluripotent Stem Cell-Derived Cardiomyocytes by Tohyama, Shugo, Hattori, Fumiyuki, Sano, Motoaki, Hishiki, Takako, Nagahata, Yoshiko, Matsuura, Tomomi, Hashimoto, Hisayuki, Suzuki, Tomoyuki, Yamashita, Hiromi, Satoh, Yusuke, Egashira, Toru, Seki, Tomohisa, Muraoka, Naoto, Yamakawa, Hiroyuki, Ohgino, Yasuyuki, Tanaka, Tomofumi, Yoichi, Masatoshi, Yuasa, Shinsuke, Murata, Mitsushige, Suematsu, Makoto, Fukuda, Keiichi

“…Heart disease remains a major cause of death despite advances in medical technology. Heart-regenerative therapy that uses pluripotent stem cells (PSCs) is a…”
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Nongenetic method for purifying stem cell-derived cardiomyocytes by Fukuda, Keiichi, Hattori, Fumiyuki, Chen, Hao, Yamashita, Hiromi, Tohyama, Shugo, Satoh, Yu-suke, Yuasa, Shinsuke, Li, Weizhen, Yamakawa, Hiroyuki, Tanaka, Tomofumi, Onitsuka, Takeshi, Shimoji, Kenichiro, Ohno, Yohei, Egashira, Toru, Kaneda, Ruri, Murata, Mitsushige, Hidaka, Kyoko, Morisaki, Takayuki, Sasaki, Erika, Suzuki, Takeshi, Sano, Motoaki, Makino, Shinji, Oikawa, Shinzo

“…Staining with a mitochondrial dye permits high-purity isolation of cardiomyocytes from embryonic and induced pluripotent stem cells of several species, without…”
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Efficient protocol for the differentiation of kidney podocytes from induced pluripotent stem cells, involving the inhibition of mTOR by Yasuda, Masahiro, Kato, Tadashi, Okano, Mai, Yamashita, Hiromi, Matsuoka, Yoshikazu, Shirouzu, Yasumasa, Fujioka, Tatsuya, Hattori, Fumiyuki, Tsuji, Shoji, Kaneko, Kazunari, Hitomi, Hirofumi

“…The mechanistic/mammalian target of rapamycin (mTOR) is involved in a wide range of cellular processes. However, the role of mTOR in podocytes remains unclear…”
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In vitro pharmacologic testing using human induced pluripotent stem cell-derived cardiomyocytes by Tanaka, Tomofumi, Tohyama, Shugo, Murata, Mitsushige, Nomura, Fumimasa, Kaneko, Tomoyuki, Chen, Hao, Hattori, Fumiyuki, Egashira, Toru, Seki, Tomohisa, Ohno, Yohei, Koshimizu, Uichi, Yuasa, Shinsuke, Ogawa, Satoshi, Yamanaka, Shinya, Yasuda, Kenji, Fukuda, Keiichi

“…The lethal ventricular arrhythmia Torsade de pointes (TdP) is the most common reason for the withdrawal or restricted use of many cardiovascular and…”
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Disease characterization using LQTS-specific induced pluripotent stem cells by EGASHIRA, Toru, YUASA, Shinsuke, KURODA, Yusuke, YAE, Kojiro, HASHIMOTO, Hisayuki, TANAKA, Tomofumi, HATTORI, Fumiyuki, SATO, Toshiaki, MIYOSHI, Shunichiro, TAKATSUKI, Seiji, MURATA, Mitsushige, KUROKAWA, Junko, SUZUKI, Tomoyuki, FURUKAWA, Tetsushi, MAKITA, Naomasa, AIBA, Takeshi, SHIMIZU, Wataru, HORIE, Minoru, KAMIYA, Kaichiro, KODAMA, Itsuo, OGAWA, Satoshi, FUKUDA, Keiichi, AIZAWA, Yoshiyasu, YAMAKAWA, Hiroyuki, MATSUHASHI, Tomohiro, OHNO, Yohei, TOHYAMA, Shugo, OKATA, Shinichiro, SEKI, Tomohisa

“…Long QT syndrome (LQTS) is an inheritable and life-threatening disease; however, it is often difficult to determine disease characteristics in sporadic cases…”
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“All-in-one” in vitro selection of collagen-binding vascular endothelial growth factor by Park, Shin-Hye, Uzawa, Takanori, Hattori, Fumiyuki, Ogino, Shuichi, Morimoto, Naoki, Tsuneda, Satoshi, Ito, Yoshihiro

“…To enhance the therapeutic effect of growth factors, a powerful strategy is to direct their localization to damaged sites. To treat skin wounds and myocardial…”
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Possible internal viral shedding and interferon production after clinical recovery from COVID-19: Case report by Ito, Asuka, Okada, Takayuki, Minato, Naoki, Hattori, Fumiyuki

“…A 70-year-old man underwent off-pump coronary artery bypass grafting 28 days after his recovery from coronavirus disease 2019 (COVID-19), which was confirmed…”
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Compact automated culture machine for human induced pluripotent stem cell maintenance and differentiation by Bando, Kazunori, Yamashita, Hiromi, Tsumori, Motomu, Minoura, Hayase, Okumura, Koji, Hattori, Fumiyuki

“…The technologies used to generate human induced pluripotent stem cell (iPSC) from somatic cells potentially enable the wide application of iPSC-derived…”
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G-CSF Promotes the Proliferation of Developing Cardiomyocytes In Vivo and in Derivation from ESCs and iPSCs by Shimoji, Kenichiro, Yuasa, Shinsuke, Onizuka, Takeshi, Hattori, Fumiyuki, Tanaka, Tomofumi, Hara, Mie, Ohno, Yohei, Chen, Hao, Egasgira, Toru, Seki, Tomohisa, Yae, Kojiro, Koshimizu, Uichi, Ogawa, Satoshi, Fukuda, Keiichi

“…During a screen for humoral factors that promote cardiomyocyte differentiation from embryonic stem cells (ESCs), we found marked elevation of granulocyte…”
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Ligand Specificity Determined by Differentially Arranged Common Ligand-binding Residues in Bacterial Amino Acid Chemoreceptors Tsr and Tar by Tajima, Hirotaka, Imada, Katsumi, Sakuma, Mayuko, Hattori, Fumiyuki, Nara, Toshifumi, Kamo, Naoki, Homma, Michio, Kawagishi, Ikuro

“…Escherichia coli has closely related amino acid chemoreceptors with distinct ligand specificity, Tar for l-aspartate and Tsr for l-serine. Crystallography of…”
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Metabolic Remodeling Induced by Mitochondrial Aldehyde Stress Stimulates Tolerance to Oxidative Stress in the Heart by Endo, Jin, Sano, Motoaki, Katayama, Takaharu, Hishiki, Takako, Shinmura, Ken, Morizane, Shintaro, Matsuhashi, Tomohiro, Katsumata, Yoshinori, Zhang, Yan, Ito, Hideyuki, Nagahata, Yoshiko, Marchitti, Satori, Nishimaki, Kiyomi, Wolf, Alexander Martin, Nakanishi, Hiroki, Hattori, Fumiyuki, Vasiliou, Vasilis, Adachi, Takeshi, Ohsawa, Ikuroh, Taguchi, Ryo, Hirabayashi, Yoshio, Ohta, Shigeo, Suematsu, Makoto, Ogawa, Satoshi, Fukuda, Keiichi

“…RATIONALE:Aldehyde accumulation is regarded as a pathognomonic feature of oxidative stress–associated cardiovascular disease. OBJECTIVE:We investigated how the…”
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G-CSF influences mouse skeletal muscle development and regeneration by stimulating myoblast proliferation by Hara, Mie, Yuasa, Shinsuke, Shimoji, Kenichiro, Onizuka, Takeshi, Hayashiji, Nozomi, Ohno, Yohei, Arai, Takahide, Hattori, Fumiyuki, Kaneda, Ruri, Kimura, Kensuke, Makino, Shinji, Sano, Motoaki, Fukuda, Keiichi

“…After skeletal muscle injury, neutrophils, monocytes, and macrophages infiltrate the damaged area; this is followed by rapid proliferation of myoblasts derived…”
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Overexpression of mitochondrial peroxiredoxin-3 prevents left ventricular remodeling and failure after myocardial infarction in mice by MATSUSHIMA, Shouji, IDE, Tomomi, OIKAWA, Shinzo, KINUGAWA, Shintaro, TSUTSUI, Hiroyuki, YAMATO, Mayumi, MATSUSAKA, Hidenori, HATTORI, Fumiyuki, IKEUCHI, Masaki, KUBOTA, Tom, SUNAGAWA, Kenji, HASEGAWA, Yasuhiro, KURIHARA, Tatsuya

“…Mitochondrial oxidative stress and damage play major roles in the development and progression of left ventricular (LV) remodeling and failure after myocardial…”
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Transient inhibition of BMP signaling by Noggin induces cardiomyocyte differentiation of mouse embryonic stem cells by Fukuda, Keiichi, Yuasa, Shinsuke, Itabashi, Yuji, Koshimizu, Uichi, Tanaka, Tomofumi, Sugimura, Keijiro, Kinoshita, Masayoshi, Hattori, Fumiyuki, Fukami, Shin-ichi, Shimazaki, Takuya, Okano, Hideyuki, Ogawa, Satoshi

“…Embryonic stem (ES) cells are a promising source of cardiomyocytes, but clinical application of ES cells has been hindered by the lack of reliable selective…”
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Sema3a maintains normal heart rhythm through sympathetic innervation patterning by Fukuda, Keiichi, Ieda, Masaki, Kanazawa, Hideaki, Kimura, Kensuke, Hattori, Fumiyuki, Ieda, Yasuyo, Taniguchi, Masahiko, Lee, Jong-Kook, Matsumura, Keisuke, Tomita, Yuichi, Miyoshi, Shunichiro, Shimoda, Kouji, Makino, Shinji, Sano, Motoaki, Kodama, Itsuo, Ogawa, Satoshi

“…Sympathetic innervation is critical for effective cardiac function. However, the developmental and regulatory mechanisms determining the density and patterning…”
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E-cadherin-coated plates maintain pluripotent ES cells without colony formation by Nagaoka, Masato, Koshimizu, Uichi, Yuasa, Shinsuke, Hattori, Fumiyuki, Chen, Hao, Tanaka, Tomofumi, Okabe, Masaru, Fukuda, Keiichi, Akaike, Toshihiro

“…Embryonic stem (ES) cells cultured on gelatin-coated plates or feeder layers form tight aggregated colonies by the E-cadherin-mediated cell-cell adhesions…”
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Perturbation of the titin/MURF1 signaling complex is associated with hypertrophic cardiomyopathy in a fish model and in human patients by Higashikuse, Yuta, Mittal, Nishant, Arimura, Takuro, Yoon, Sung Han, Oda, Mayumi, Enomoto, Hirokazu, Kaneda, Ruri, Hattori, Fumiyuki, Suzuki, Takeshi, Kawakami, Atsushi, Gasch, Alexander, Furukawa, Tetsushi, Labeit, Siegfried, Fukuda, Keiichi, Kimura, Akinori, Makino, Shinji

“…Hypertrophic cardiomyopathy (HCM) is a hereditary disease characterized by cardiac hypertrophy with diastolic dysfunction. Gene mutations causing HCM have been…”
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Time-lapse imaging of cell cycle dynamics during development in living cardiomyocyte by Hashimoto, Hisayuki, Yuasa, Shinsuke, Tabata, Hidenori, Tohyama, Shugo, Hayashiji, Nozomi, Hattori, Fumiyuki, Muraoka, Naoto, Egashira, Toru, Okata, Shinichiro, Yae, Kojiro, Seki, Tomohisa, Nishiyama, Takahiko, Nakajima, Kazunori, Sakaue-Sawano, Asako, Miyawaki, Atsushi, Fukuda, Keiichi

“…Abstract Mammalian cardiomyocytes withdraw from the cell cycle shortly after birth, although it remains unclear how cardiomyocyte cell cycles behave during…”
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