Search Results - "Hatto, Julia D. I"

Solubility-Driven Optimization of Phosphodiesterase‑4 Inhibitors Leading to a Clinical Candidate by Press, Neil J, Taylor, Roger J, Fullerton, Joseph D, Tranter, Pamela, McCarthy, Clive, Keller, Thomas H, Arnold, Nicola, Beer, David, Brown, Lyndon, Cheung, Robert, Christie, Julie, Denholm, Alastair, Haberthuer, Sandra, Hatto, Julia D. I, Keenan, Mark, Mercer, Mark K, Oakman, Helen, Sahri, Helene, Tuffnell, Andrew R, Tweed, Morris, Tyler, John W, Wagner, Trixie, Fozard, John R, Trifilieff, Alexandre

“…The solubility-driven optimization of a series of 1,7-napthyridine phosphodiesterase-4 inhibitors is described. Directed structural changes resulted in…”
Get full text

Discovery and Optimization of 4-(8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl)transcyclohexanecarboxylic Acid, an Improved PDE4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease (COPD) by Press, Neil J, Taylor, Roger J, Fullerton, Joseph D, Tranter, Pamela, McCarthy, Clive, Keller, Thomas H, Arnold, Nicola, Beer, David, Brown, Lyndon, Cheung, Robert, Christie, Julie, Denholm, Alastair, Haberthuer, Sandra, Hatto, Julia D I, Keenan, Mark, Mercer, Mark K, Oakman, Helen, Sahri, Helene, Tuffnell, Andrew R, Tweed, Morris, Trifilieff, Alexandre

“…Herein we describe the optimization of a series of PDE4 inhibitors, with special focus on solubility and pharamcokinetics, to clinical compound 2,…”
Get full text

Potent and selective xanthine-based inhibitors of phosphodiesterase 5 by Arnold, Nichola J., Arnold, Ruth, Beer, David, Bhalay, Gurdip, Collingwood, Stephen P., Craig, Sarah, Devereux, Nicholas, Dodds, Mark, Dunstan, Andrew R., Fairhurst, Robin A., Farr, David, Fullerton, Joseph D., Glen, Angela, Gomez, Sylvie, Haberthuer, Sandra, Hatto, Julia D.I., Howes, Colin, Jones, Darryl, Keller, Thomas H., Leuenberger, Beate, Moser, Heinz E., Muller, Irene, Naef, Reto, Nicklin, Paul A., Sandham, David A., Turner, Katharine L., Tweed, Morris F., Watson, Simon J., Zurini, Mauro

“…Inhibitors of PDE5 are useful therapeutic agents for treatment of erectile dysfunction. A series of novel xanthine derivatives has been identified as potent…”
Get full text

A new orally bioavailable dual adenosine A2B/A3 receptor antagonist with therapeutic potential by PRESS, Neil J, TAYLOR, Roger J, HATTO, Julia D. I, KEENAN, Mark, MERCER, Mark K, PRESS, Nicola E, SAHRI, Helene, TUFFNELL, Andrew R, TWEED, Morris, FOZARD, John R, FULLERTON, Joseph D, TRANTER, Pamela, MCCARTHY, Clive, KELLER, Thomas H, BROWN, Lyndon, CHEUNG, Robert, CHRISTIE, Julie, HABERTHUER, Sandra

“…The synthesis and SAR of 5-heterocycle-substituted aminothiazole adenosine receptor antagonists is described. Several compounds show high affinity and…”
Get full text

Discovery and Optimization of 4‑(8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl)­transcyclohexane­carboxylic Acid, an Improved PDE4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease (COPD) by Press, Neil J., Taylor, Roger J., Fullerton, Joseph D., Tranter, Pamela, McCarthy, Clive, Keller, Thomas H., Arnold, Nicola, Beer, David, Brown, Lyndon, Cheung, Robert, Christie, Julie, Denholm, Alastair, Haberthuer, Sandra, Hatto, Julia D. I., Keenan, Mark, Mercer, Mark K., Oakman, Helen, Sahri, Helene, Tuffnell, Andrew R., Tweed, Morris, Trifilieff, Alexandre

“…Herein we describe the optimization of a series of PDE4 inhibitors, with special focus on solubility and pharamcokinetics, to clinical compound 2,…”
Get full text