Search Results - "Hattler, Julian"

Macrophages but not Astrocytes Harbor HIV DNA in the Brains of HIV-1-Infected Aviremic Individuals on Suppressive Antiretroviral Therapy by Ko, Allen, Kang, Guobin, Hattler, Julian B., Galadima, Hadiza I., Zhang, Junfeng, Li, Qingsheng, Kim, Woong-Ki

“…The question of whether the human brain is an anatomical site of persistent HIV-1 infection during suppressive antiretroviral therapy (ART) is critical, but…”
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CSF1R inhibition depletes brain macrophages and reduces brain virus burden in SIV-infected macaques by Bohannon, Diana G, Zablocki-Thomas, Laurent D, Leung, Evan S, Dupont, Jinbum K, Hattler, Julian B, Kowalewska, Jolanta, Zhao, Miaoyun, Luo, Jiangtao, Salemi, Marco, Amedee, Angela M, Li, Qingsheng, Kuroda, Marcelo J, Kim, Woong-Ki

“…Perivascular macrophages (PVMs) and, to a lesser degree, microglia are targets and reservoirs of HIV and simian immunodeficiency virus (SIV) in the brain…”
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A Zika virus primary isolate induces neuroinflammation, compromises the blood‐brain barrier and upregulates CXCL12 in adult macaques by Panganiban, Antonito T., Blair, Robert V., Hattler, Julian B., Bohannon, Diana G., Bonaldo, Myrna C., Schouest, Blake, Maness, Nicholas J., Kim, Woong‐Ki

“…Zika virus (ZIKV) is a flavivirus that can cause neuropathogenesis in adults and fetal neurologic malformation following the infection of pregnant women. We…”
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Downregulation of CCR5 on brain perivascular macrophages in simian immunodeficiency virus‐infected rhesus macaques by Hattler, Julian B., Irons, Derek L., Luo, Jiangtao, Kim, Woong‐Ki

“…Background C‐C chemokine receptor 5 (CCR5) is a major coreceptor for Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) cell entry;…”
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Lentiviral infection of proliferating brain macrophages in HIV and simian immunodeficiency virus encephalitis despite sterile alpha motif and histidine-aspartate domain-containing protein 1 expression by Lindgren, Allison A, Filipowicz, Adam R, Hattler, Julian B, Kim, Soon Ok, Chung, Hye Kyung, Kuroda, Marcelo J, Johnson, Edward M, Kim, Woong-Ki

“…OBJECTIVE:HIV-1 infection of the brain and related cognitive impairment remain prevalent in HIV-1-infected individuals despite combination antiretroviral…”
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Perivascular macrophages in the neonatal macaque brain undergo massive necroptosis after simian immunodeficiency virus infection by Bohannon, Diana G., Wang, Yueying, Reinhart, Colin H., Hattler, Julian B., Luo, Jiangtao, Okhravi, Hamid R., Zhang, Jianshui, Li, Qingsheng, Kuroda, Marcelo J., Kim, Jayoung, Kim, Woong‐Ki

“…We previously showed that rhesus macaques neonatally infected with simian immunodeficiency virus (SIV) do not develop SIV encephalitis (SIVE) and maintain low…”
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Development of Droplet Digital PCR-Based Assays to Quantify HIV Proviral and Integrated DNA in Brain Tissues from Viremic Individuals with Encephalitis and Virally Suppressed Aviremic Individuals by Chung, Hye Kyung, Hattler, Julian B, Narola, Jigna, Babbar, Harita, Cai, Yanhui, Abdel-Mohsen, Mohamed, Kim, Woong-Ki

“…Although combination antiretroviral therapy (cART) can suppress the replication of HIV, the virus persists and rebounds when treatment is stopped. To find a…”
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STAT4 Regulates the CD8 + Regulatory T Cell/T Follicular Helper Cell Axis and Promotes Atherogenesis in Insulin-Resistant Ldlr -/- Mice by Taghavie-Moghadam, Parésa L, Waseem, Tayab C, Hattler, Julian, Glenn, Lindsey M, Dobrian, Anca D, Kaplan, Mark H, Yang, Yi, Nurieva, Roza, Nadler, Jerry L, Galkina, Elena V

“…The metabolic syndrome and diabetic conditions support atherosclerosis, but the exact mechanisms for accelerated atherogenesis remain unclear. Although the…”
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CSF1R blockade improves clinical parameters in prediabetic rhesus macaques by Stahr, Natalie Ann, Phou, Amy, Hattler, Julian, McGuire, David, Kim, Woong-Ki

“…It is unknown whether dysregulated CSF1R himonocytes/macrophages drive the progression to diabetes and if their removal and endogenous replacement with fresh…”
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Lentiviral infection of proliferating brain macrophages in SIV and HIV encephalitis despite SAMHD1 expression by Lindgren, Allison A, Filipowicz, Adam R, Hattler, Julian B, Kim, Soon Ok, Chung, Hye Kyung, Kuroda, Marcelo J, Johnson, Edward M, Kim, Woong-Ki

“…OBJECTIVE:HIV-1 infection of the brain and related cognitive impairment remain prevalent in HIV-1-infected subjects despite combination antiretroviral therapy…”
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STAT4 regulates CD8+Treg/Tfh cell axis and promotes atherogenesis in insulin-resistant Ldlr−/− mice by Taghavie-Moghadam, Parésa L, Wassem, Tayab C, Hattler, Julian, Glenn, Lindsey M, Dobrian, Anca D, Kaplan, Mark H, Yang, Yi, Nurieva, Roza, Nadler, Jerry L, Galkina, Elena V

“…The metabolic syndrome and diabetic conditions support atherosclerosis, but the exact mechanisms for accelerated atherogenesis remain unclear. While the…”
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