Search Results - "Hattersley, G"

Abaloparatide, a novel PTH receptor agonist, increased bone mass and strength in ovariectomized cynomolgus monkeys by increasing bone formation without increasing bone resorption by Doyle, N., Varela, A., Haile, S., Guldberg, R., Kostenuik, P. J., Ominsky, M. S., Smith, S. Y., Hattersley, G.

“…Summary Abaloparatide, a novel PTH1 receptor agonist, increased bone formation in osteopenic ovariectomized cynomolgus monkeys while increasing cortical and…”
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Abaloparatide increases bone mineral density and bone strength in ovariectomized rabbits with glucocorticoid-induced osteopenia by Chandler, H., Brooks, D.J., Hattersley, G., Bouxsein, M.L., Lanske, B.

“…Summary Glucorticoid (GC) therapy is the commonest cause of secondary osteoporosis. Ovariectomized rabbits receiving the GC methylprednisolone for 6 weeks…”
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Abaloparatide-SC improves trabecular microarchitecture as assessed by trabecular bone score (TBS): a 24-week randomized clinical trial by Bilezikian, J. P., Hattersley, G., Fitzpatrick, L. A., Harris, A. G., Shevroja, E., Banks, K., Leder, B. Z., Zanchetta, J. R., Hans, D.

“…Summary In a phase 2 trial of 222 postmenopausal women with osteoporosis aged 55 to 85 years randomized to one of three different doses of abaloparatide-SC,…”
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Chemerin induces endothelial cell inflammation: activation of nuclear factor-kappa beta and monocyte-endothelial adhesion by Dimitriadis, Georgios K, Kaur, Jaspreet, Adya, Raghu, Miras, Alexander D, Mattu, Harman S, Hattersley, John G, Kaltsas, Gregory, Tan, Bee K, Randeva, Harpal S

“…Chemerin, a chemoattractant protein, acts a G-protein coupled chemokine receptor, Chemokine like Receptor 1/ChemR23; levels of which are elevated in…”
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Bone mineral density response rates are greater in patients treated with abaloparatide compared with those treated with placebo or teriparatide: Results from the ACTIVE phase 3 trial by Miller, P.D., Hattersley, G., Lau, E., Fitzpatrick, L.A., Harris, A.G., Williams, G.C., Hu, M.-Y., Riis, B.J., Russo, L., Christiansen, C.

“…Abaloparatide is a 34–amino acid peptide that selectively binds to the RG conformation of the parathyroid hormone receptor type 1. It was developed for the…”
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Abaloparatide effect on forearm bone mineral density and wrist fracture risk in postmenopausal women with osteoporosis by Watts, N.B., Hattersley, G., Fitzpatrick, L.A., Wang, Y., Williams, G.C., Miller, P.D., Cosman, F.

“…Purpose Wrist fractures are common, contribute significantly to morbidity in women with postmenopausal osteoporosis, and occur predominantly at the ultradistal…”
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RAD140, an orally available selective androgen receptor modulator, exhibits potent anti-tumor activity in ER+AR+ breast cancer models by Yu, Z, Brown, J, Saeh, J, Hattersley, G

“…Breast cancer is the second leading cause of cancer-related mortality (or women in the US with more than 40,000 deaths predicted in 2016. Hormone receptor…”
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Correction to: Abaloparatide effect on forearm bone mineral density and wrist fracture risk in postmenopausal women with osteoporosis by Watts, N. B., Hattersley, G., Fitzpatrick, L. A., Wang, Y., Williams, G. C., Miller, P. D., Cosman, F.

“…The original version of this article, published on 21 March 2019, unfortunately contains some typos in Figs. 2, 3, 4, and Supplemental Fig. 1. The corrected…”
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Forearm bone mineral density and fracture incidence in postmenopausal women with osteoporosis: results from the ACTIVExtend phase 3 trial by Watts, N.B., Dore, R.K., Baim, S., Mitlak, B., Hattersley, G., Wang, Y., Rozental, T.D., LeBoff, M.S.

“…Summary Abaloparatide increased ultradistal radius bone mineral density (BMD) in the Abaloparatide Comparator Trial in Vertebral Endpoints (ACTIVE) trial. Over…”
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Correction to: Abaloparatide effect on forearm bone mineral density and wrist fracture risk in postmenopausal women with osteoporosis by Watts, N. B., Hattersley, G., Fitzpatrick, L. A., Wang, Y., Williams, G. C., Miller, P. D., Cosman, F.

“…The original version of this article, published on 21 March 2019, unfortunately contained a mistake…”
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The localized expression of extracellular matrix components in healing tendon insertion sites: an in situ hybridization study by Thomopoulos, S, Hattersley, G, Rosen, V, Mertens, M, Galatz, L, Williams, G.R, Soslowsky, L.J

“…The localized expression of a number of extracellular matrix genes was evaluated over time in a novel rat rotator cuff injury model. The supraspinatus tendons…”
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Quantifying the improvement of surrogate indices of hepatic insulin resistance using complex measurement techniques by Hattersley, John G, Möhlig, Matthias, Roden, Michael, Arafat, Ayman M, Loeffelholz, Christian V, Nowotny, Peter, Machann, Jürgen, Hierholzer, Johannes, Osterhoff, Martin, Khan, Michael, Pfeiffer, Andreas F H, Weickert, Martin O

“…We evaluated the ability of simple and complex surrogate-indices to identify individuals from an overweight/obese cohort with hepatic insulin-resistance…”
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Cloning and Expression of the Wnt Antagonists Sfrp-2 and Frzb during Chick Development by Ladher, R.K., Church, V.L., Allen, S., Robson, L., Abdelfattah, A., Brown, N.A., Hattersley, G., Rosen, V., Luyten, F.P., Dale, L., Francis-West, P.H.

“…The Wnt genes are known to play fundamental roles during patterning and development of a number of embryonic structures. Receptors for Wnts are members of the…”
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Ectopic induction of tendon and ligament in rats by growth and differentiation factors 5, 6, and 7, members of the TGF-beta gene family by Wolfman, N M, Hattersley, G, Cox, K, Celeste, A J, Nelson, R, Yamaji, N, Dube, J L, DiBlasio-Smith, E, Nove, J, Song, J J, Wozney, J M, Rosen, V

“…Little is known about the regulatory signals involved in tendon and ligament formation, and this lack of understanding has hindered attempts to develop…”
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Comment on “Minimal and Maximal Models to Quantitate Glucose Metabolism: Tools to Measure, to Simulate and to Run in Silico Clinical Trials” by Eichenlaub, Manuel, Saccomani, M. P., Hattersley, John G., Khovanova, Natasha A.

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A Glucose-Only Model to Extract Physiological Information from Postprandial Glucose Profiles in Subjects with Normal Glucose Tolerance by Eichenlaub, Manuel M., Khovanova, Natasha A., Gannon, Mary C., Nuttall, Frank Q., Hattersley, John G.

“…Background: Current mathematical models of postprandial glucose metabolism in people with normal and impaired glucose tolerance rely on insulin measurements…”
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Bayesian parameter estimation in the oral minimal model of glucose dynamics from non-fasting conditions using a new function of glucose appearance by Eichenlaub, Manuel M., Hattersley, John G., Gannon, Mary C., Nuttall, Frank Q., Khovanova, Natasha A.

“…•Bayesian parameter estimation in the oral minimal model of glucose dynamics.•Identification from non-fasting conditions.•Introduction of a novel function…”
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Modulation of Amino Acid Metabolic Signatures by Supplemented Isoenergetic Diets Differing in Protein and Cereal Fiber Content by Hattersley, John G, Pfeiffer, Andreas F. H, Roden, Michael, Petzke, Klaus-Jürgen, Hoffmann, Daniela, Rudovich, Natalia N, Randeva, Harpal S, Vatish, Manu, Osterhoff, Martin, Goegebakan, Özlem, Hornemann, Silke, Nowotny, Peter, Machann, Jürgen, Hierholzer, Johannes, von Loeffelholz, Christian, Möhlig, Matthias, Arafat, Ayman M, Weickert, Martin O

“…Context: Amino-acid (AA) metabolic signatures differ in insulin-resistant (IR) obese vs normal-weight subjects, improve after weight loss, and seem to predict…”
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Metabolic phenotype of male obesity-related secondary hypogonadism pre-replacement and post-replacement therapy with intra-muscular testosterone undecanoate therapy by Dimitriadis, Georgios K., Randeva, Harpal S., Aftab, Saboor, Ali, Asad, Hattersley, John G., Pandey, Sarojini, Grammatopoulos, Dimitris K., Valsamakis, Georgios, Mastorakos, Georgios, Jones, T. Hugh, Barber, Thomas M.

“…Aim To explore the metabolic phenotype of obesity-related secondary hypogonadism (SH) in men pre-replacement and post-replacement therapy with long-acting…”
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Screening for malnutrition in patients with gastro-entero-pancreatic neuroendocrine tumours: a cross-sectional study by Qureshi, Sheharyar A, Burch, Nicola, Druce, Maralyn, Hattersley, John G, Khan, Saboor, Gopalakrishnan, Kishore, Darby, Catherine, Wong, John L H, Davies, Louise, Fletcher, Simon, Shatwell, William, Sothi, Sharmila, Randeva, Harpal S, Dimitriadis, Georgios K, Weickert, Martin O

“…ObjectivesTo investigate whether screening for malnutrition using the validated malnutrition universal screening tool (MUST) identifies specific…”
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