Search Results - "Hatstat, A Katherine"

Predicting PY motif-mediated protein-protein interactions in the Nedd4 family of ubiquitin ligases by Hatstat, A. Katherine, Pupi, Michael D, McCafferty, Dewey G

“…The Nedd4 family contains several structurally related but functionally distinct HECT-type ubiquitin ligases. The members of the Nedd4 family are known to…”
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Synthesis and analysis of novel catecholic ligands as inhibitors of catechol-O-methyltransferase by Katherine Hatstat, A., Kennedy, Grace M., Squires, Trevor R., Xhafkollari, Gisela, Skyler Cochrane, C., Cafiero, Mauricio, Peterson, Larryn W.

“…[Display omitted] •Five catechol nitrile derivatives were designed, synthesized (46–93%) and fully characterized.•An in vitro assay was used to determine the…”
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Characterization of Small-Molecule-Induced Changes in Parkinson's-Related Trafficking via the Nedd4 Ubiquitin Signaling Cascade by Hatstat, A Katherine, Ahrendt, Hannah D, Foster, Matthew W, Mayne, Leland, Moseley, M Arthur, Englander, S Walter, McCafferty, Dewey G

“…The benzdiimidazole NAB2 rescues α-synuclein-associated trafficking defects associated with early onset Parkinson's disease in a Nedd4-dependent manner…”
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Robust and facile purification of full-length, untagged human Nedd4 as a recombinant protein from Escherichia coli by Hatstat, A. Katherine, McCafferty, Dewey G.

“…Nedd4 is an E3 ubiquitin ligase that has received increased attention due to its role in the maintenance of proteostasis and in cellular stress responses…”
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Small Molecule Improvement of Trafficking Defects in Models of Neurodegeneration by Hatstat, A. Katherine, Pupi, Michael D, Reinhart, Michaela C, McCafferty, Dewey G

“…Disrupted cellular trafficking and transport processes are hallmarks of many neurodegenerative disorders (NDs). Recently, efforts have been made toward…”
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Chemoproteomic-enabled characterization of small GTPase Rab1a as a target of an N -arylbenzimidazole ligand's rescue of Parkinson's-associated cell toxicity by Hatstat, A Katherine, Quan, Baiyi, Bailey, Morgan A, Fitzgerald, Michael C, Reinhart, Michaela C, McCafferty, Dewey G

“…The development of phenotypic models of Parkinson's disease (PD) has enabled screening and identification of phenotypically active small molecules that restore…”
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MP2//DFT calculations of interaction energies between acetaminophen and acetaminophen analogues and the aryl sulfotransferase active site by DiGiovanni, Katherine M., Katherine Hatstat, A., Rote, Jennifer, Cafiero, Mauricio

“…Acetaminophen docked and optimized (BHandHLYP/3-21G) in the rigid (left) and flexible (right) aryl sulfotransferase active site. [Display omitted] ► We examine…”
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Ab initio study of electronic interaction energies and desolvation energies for dopaminergic ligands in the catechol-O-methyltransferase active site by Hatstat, A. Katherine, Morris, Mallory, Peterson, Larryn W., Cafiero, Mauricio

“…[Display omitted] •MP2 and M06L calculations of dopamine and proposed dopaminergic derivatives as ligands of COMT.•Comparison of ligand affinity under in vacuo…”
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Chemoproteomic-enabled characterization of small GTPase Rab1a as a target of an -arylbenzimidazole ligand's rescue of Parkinson's-associated cell toxicity by Hatstat, A. Katherine, Quan, Baiyi, Bailey, Morgan A, Fitzgerald, Michael C, Reinhart, Michaela C, McCafferty, Dewey G

“…The development of phenotypic models of Parkinson's disease (PD) has enabled screening and identification of phenotypically active small molecules that restore…”
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