Search Results - "Hatmal, Mamon"

Combining Stochastic Deformation/Relaxation and Intermolecular Contacts Analysis for Extracting Pharmacophores from Ligand–Receptor Complexes by Hatmal, Ma’mon M, Taha, Mutasem O

“…We previously combined molecular dynamics (classical or simulated annealing) with ligand–receptor contacts analysis as a means to extract valid pharmacophore…”
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Discovery of new STAT3 inhibitors as anticancer agents using ligand-receptor contact fingerprints and docking-augmented machine learning by Jaradat, Nour Jamal, Alshaer, Walhan, Hatmal, Mamon, Taha, Mutasem Omar

“…STAT3 belongs to a family of seven vital transcription factors. High levels of STAT3 are detected in several types of cancer. Hence, STAT3 inhibition is…”
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Selection and targeting of EpCAM protein by ssDNA aptamer by Alshaer, Walhan, Ababneh, Nida, Hatmal, Mamon, Izmirli, Heba, Choukeife, Moujab, Shraim, Alaa, Sharar, Nour, Abu-Shiekah, Aya, Odeh, Fadwa, Al Bawab, Abeer, Awidi, Abdalla, Ismail, Said

“…Aptamers are molecules that reveal highly complex and refined molecular recognition properties. These molecules are capable of binding with high affinity and…”
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Antiviral and Immunomodulatory Effects of Phytochemicals from Honey against COVID-19: Potential Mechanisms of Action and Future Directions by Al-Hatamleh, Mohammad A. I., Hatmal, Ma’mon M., Sattar, Kamran, Ahmad, Suhana, Mustafa, Mohd Zulkifli, Bittencourt, Marcelo De Carvalho, Mohamud, Rohimah

“…The new coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has recently put the world under stress,…”
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Correction: Selection and targeting of EpCAM protein by ssDNA aptamer by Alshaer, Walhan, Ababneh, Nidaa A, Hatmal, Mamon, Izmirli, Heba, Choukeife, Moujab, Shraim, Alaa, Sharar, Nour, Abu-Shiekah, Aya, Odeh, Fadwa, Al Bawab, Abeer, Awidi, Abdalla, Ismail, Said

“…[This corrects the article DOI: 10.1371/journal.pone.0189558.]…”
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siRNA: Mechanism of action, challenges, and therapeutic approaches by Alshaer, Walhan, Zureigat, Hadil, Al Karaki, Arwa, Al-Kadash, Abdulfattah, Gharaibeh, Lobna, Hatmal, Ma'mon M., Aljabali, Alaa A.A., Awidi, Abdalla

“…Owing to specific and compelling gene silencing, RNA interference (RNAi) is expected to become an essential approach in treating a variety of infectious,…”
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Side Effects and Perceptions Following COVID-19 Vaccination in Jordan: A Randomized, Cross-Sectional Study Implementing Machine Learning for Predicting Severity of Side Effects by Hatmal, Ma’mon M., Al-Hatamleh, Mohammad A. I., Olaimat, Amin N., Hatmal, Malik, Alhaj-Qasem, Dina M., Olaimat, Tamadur M., Mohamud, Rohimah

“…Background: Since the coronavirus disease 2019 (COVID-19) was declared a pandemic, there was no doubt that vaccination is the ideal protocol to tackle it…”
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Comprehensive Structural and Molecular Comparison of Spike Proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and Their Interactions with ACE2 by Hatmal, Ma'mon M, Alshaer, Walhan, Al-Hatamleh, Mohammad A I, Hatmal, Malik, Smadi, Othman, Taha, Mutasem O, Oweida, Ayman J, Boer, Jennifer C, Mohamud, Rohimah, Plebanski, Magdalena

“…The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has recently emerged in China and caused a disease called coronavirus disease 2019 (COVID-19)…”
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Exploiting activity cliffs for building pharmacophore models and comparison with other pharmacophore generation methods: sphingosine kinase 1 as case study by Mousa, Lubabah A., Hatmal, Ma’mon M., Taha, Mutasem

“…Activity cliffs (ACs) are defined as closely analogous compounds of significant affinity discrepancies against certain biotarget. In this paper we propose to…”
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The Emerging Role of Heat Shock Factor 1 (HSF1) and Heat Shock Proteins (HSPs) in Ferroptosis by Aolymat, Iman, Hatmal, Ma'mon M, Olaimat, Amin N

“…Cells employ a well-preserved physiological stress response mechanism, termed the heat shock response, to activate a certain type of molecular chaperone called…”
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Downregulation of STAT3, β-Catenin, and Notch-1 by Single and Combinations of siRNA Treatment Enhance Chemosensitivity of Wild Type and Doxorubicin Resistant MCF7 Breast Cancer Cells to Doxorubicin by Alshaer, Walhan, Alqudah, Dana A, Wehaibi, Suha, Abuarqoub, Duaa, Zihlif, Malek, Hatmal, Ma'mon M, Awidi, Abdalla

“…Combinatorial therapeutic strategies using siRNA and small molecules to eradicate tumors are emerging. Targeting multiple signaling pathways decreases the…”
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Comprehensive literature review of monkeypox by Hatmal, Ma'mon M., Al-Hatamleh, Mohammad A. I., Olaimat, Amin N., Ahmad, Suhana, Hasan, Hanan, Ahmad Suhaimi, Nurfatihah Azlyna, Albakri, Khaled A., Abedalbaset Alzyoud, Anas, Kadir, Ramlah, Mohamud, Rohimah

“…The current outbreak of monkeypox (MPX) infection has emerged as a global matter of concern in the last few months. MPX is a zoonosis caused by the MPX virus…”
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Investigating the association of CD36 gene polymorphisms (rs1761667 and rs1527483) with T2DM and dyslipidemia: Statistical analysis, machine learning based prediction, and meta-analysis by Hatmal, Ma'mon M, Alshaer, Walhan, Mahmoud, Ismail S, Al-Hatamleh, Mohammad A. I, Al-Ameer, Hamzeh J, Abuyaman, Omar, Zihlif, Malek, Mohamud, Rohimah, Darras, Mais, Al Shhab, Mohammad, Abu-Raideh, Rand, Ismail, Hilweh, Al-Hamadi, Ali, Abdelhay, Ali

“…CD36 (cluster of differentiation 36) is a membrane protein involved in lipid metabolism and has been linked to pathological conditions associated with…”
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COVID-19 Vaccine Acceptance among Vulnerable Groups: Syrian Refugees in Jordan by Talafha, Qusai M, Al-Haidose, Amal, AlSamman, Ala Y, Abdallah, Saja A, Istaiteyeh, Rasha, Ibrahim, Wisam Nabeel, Hatmal, Ma'mon M, Abdallah, Atiyeh M

“…Despite the wide distribution of COVID-19 vaccines, refugees remain last in line for the intake of vaccines. Syrian refugees in Jordan reach up to 700,000…”
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Reported Adverse Effects and Attitudes among Arab Populations Following COVID-19 Vaccination: A Large-Scale Multinational Study Implementing Machine Learning Tools in Predicting Post-Vaccination Adverse Effects Based on Predisposing Factors by Hatmal, Ma'mon M, Al-Hatamleh, Mohammad A I, Olaimat, Amin N, Mohamud, Rohimah, Fawaz, Mirna, Kateeb, Elham T, Alkhairy, Omar K, Tayyem, Reema, Lounis, Mohamed, Al-Raeei, Marwan, Dana, Rasheed K, Al-Ameer, Hamzeh J, Taha, Mutasem O, Bindayna, Khalid M

“…Background: The unprecedented global spread of coronavirus disease 2019 (COVID-19) has imposed huge challenges on the healthcare facilities, and impacted every…”
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Vitamin B12 insufficiency and deficiency: a review of nondisease risk factors by Abuyaman, Omar, Abdelfattah, Ali, Shehadeh-Tout, Faten, Deeb, Ahmad A, Hatmal, Ma'mon M

“…Vitamin B12 deficiency and insufficiency can lead to both hematological and neurological impairments. This review examines nondisease causes and risk factors…”
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Common and Potential Emerging Foodborne Viruses: A Comprehensive Review by Olaimat, Amin N, Taybeh, Asma' O, Al-Nabulsi, Anas, Al-Holy, Murad, Hatmal, Ma'mon M, Alzyoud, Jihad, Aolymat, Iman, Abughoush, Mahmoud H, Shahbaz, Hafiz, Alzyoud, Anas, Osaili, Tareq, Ayyash, Mutamed, Coombs, Kevin M, Holley, Richard

“…Human viruses and viruses from animals can cause illnesses in humans after the consumption of contaminated food or water. Contamination may occur during…”
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Exploring the influence of culture conditions on kefir's anticancer properties by Hatmal, Ma'mon M, Nuirat, Abeer, Zihlif, Malek A, Taha, Mutasem O

“…Cancer is a major health problem in many parts of the world. Conventional anticancer treatments are painful, expensive, and unsafe. Therefore, demand is…”
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Vitamin B12 binding to mutated human transcobalamin, in-silico study of TCN2 alanine scanning and ClinVar missense mutations/SNPs by Abuyaman, Omar, Hatmal, Ma'mon M., Hijjawi, Nawal, Deeb, Ahmad A., Abuothman, Mohammad, Taha, Mutasem

“…Many missense mutations/SNPs of the TCN2 gene (which yield Transcobalamin (TC)) were reported in the literature but no study is available about their effect on…”
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Discovery of new Cdc2-like kinase 4 (CLK4) inhibitors via pharmacophore exploration combined with flexible docking-based ligand/receptor contact fingerprints and machine learning by Al-Tawil, Mai Fayiz, Daoud, Safa, Hatmal, Ma'mon M, Taha, Mutasem Omar

“…Cdc2-like kinase 4 (CLK4) inhibitors are of potential therapeutic value in many diseases particularly cancer. In this study, we combined extensive ligand-based…”
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