Search Results - "Hatmal, Ma’mon M."

siRNA: Mechanism of action, challenges, and therapeutic approaches by Alshaer, Walhan, Zureigat, Hadil, Al Karaki, Arwa, Al-Kadash, Abdulfattah, Gharaibeh, Lobna, Hatmal, Ma'mon M., Aljabali, Alaa A.A., Awidi, Abdalla

“…Owing to specific and compelling gene silencing, RNA interference (RNAi) is expected to become an essential approach in treating a variety of infectious,…”
Get full text

Exploiting activity cliffs for building pharmacophore models and comparison with other pharmacophore generation methods: sphingosine kinase 1 as case study by Mousa, Lubabah A., Hatmal, Ma’mon M., Taha, Mutasem

“…Activity cliffs (ACs) are defined as closely analogous compounds of significant affinity discrepancies against certain biotarget. In this paper we propose to…”
Get full text

Vitamin B12 insufficiency and deficiency: a review of nondisease risk factors by Abuyaman, Omar, Abdelfattah, Ali, Shehadeh-Tout, Faten, Deeb, Ahmad A, Hatmal, Ma'mon M

“…Vitamin B12 deficiency and insufficiency can lead to both hematological and neurological impairments. This review examines nondisease causes and risk factors…”
Get full text

Vitamin B12 binding to mutated human transcobalamin, in-silico study of TCN2 alanine scanning and ClinVar missense mutations/SNPs by Abuyaman, Omar, Hatmal, Ma'mon M., Hijjawi, Nawal, Deeb, Ahmad A., Abuothman, Mohammad, Taha, Mutasem

“…Many missense mutations/SNPs of the TCN2 gene (which yield Transcobalamin (TC)) were reported in the literature but no study is available about their effect on…”
Get full text

Combining molecular dynamics simulation and ligand-receptor contacts analysis as a new approach for pharmacophore modeling: beta-secretase 1 and check point kinase 1 as case studies by Hatmal, Ma’mon M., Jaber, Shadi, Taha, Mutasem O.

“…Ligand-based pharmacophore modeling require relatively long lists of active compounds, while a pharmacophore based on a single ligand-receptor crystallographic…”
Get full text

Docking-generated multiple ligand poses for bootstrapping bioactivity classifying Machine Learning: Repurposing covalent inhibitors for COVID-19-related TMPRSS2 as case study by Hatmal, Ma'mon M., Abuyaman, Omar, Taha, Mutasem

“…[Display omitted] In the present work we introduce the use of multiple docked poses for bootstrapping machine learning-based QSAR modelling. Ligand-receptor…”
Get full text

Global Structure of a Three-Way Junction in a Phi29 Packaging RNA Dimer Determined Using Site-Directed Spin Labeling by Zhang, Xiaojun, Tung, Chang-Shung, Sowa, Glenna Z, Hatmal, Ma’mon M, Haworth, Ian S, Qin, Peter Z

“…The condensation of bacteriophage phi29 genomic DNA into its preformed procapsid requires the DNA packaging motor, which is the strongest known biological…”
Get full text

Computer modeling of nitroxide spin labels on proteins by Hatmal, Ma'mon M., Li, Yiyu, Hegde, Balachandra G., Hegde, Prabhavati B., Jao, Christine C., Langen, Ralf, Haworth, Ian S.

“…Electron paramagnetic resonance using site‐directed spin labeling can be used as an approach for determination of protein structures that are difficult to…”
Get full text

Ligand-based modeling followed by in vitro bioassay yielded new potent glucokinase activators by Taha, Mutasem O., Habash, Maha, Hatmal, Ma’mon M., Abdelazeem, Ahmed H., Qandil, Amjad

“…Pharmacophore/QSAR modelling accessed new potent glucokinase activators. •30 Glucokinase activators were modeled by a combination of pharmacophore and QSAR…”
Get full text

Idealized Models of Protofilaments of Human Islet Amyloid Polypeptide by Li, Yiyu, Hatmal, Ma’mon M, Langen, Ralf, Haworth, Ian S

“…Fibrils formed by assembly of human islet amyloid polypeptide (hIAPP) are found in most patients with type II diabetes. Structurally, these fibrils are…”
Get full text

Understanding the challenges to COVID-19 vaccines and treatment options, herd immunity and probability of reinfection by Al-Hatamleh, Mohammad A.I., Abusalah, Mai A., Hatmal, Ma'mon M., Alshaer, Walhan, Ahmad, Suhana, Mohd-Zahid, Manali H., Rahman, Engku Nur Syafirah E.A., Yean, Chan Y., Alias, Iskandar Z., Uskoković, Vuk, Mohamud, Rohimah

“…على عكس الأوبئة في الماضي، شهد تفشي مرض كوفيد-19 الذي ينتقل بسرعة في جميع أنحاء العالم نهجا مختلفا تماما للضوابط والتدابير التي تم تنفيذها في جميع البلدان…”
Get full text

Conformational Variants of Duplex DNA Correlated with Cytosine-rich Chromosomal Fragile Sites by Tsai, Albert G., Engelhart, Aaron E., Hatmal, Ma'mon M., Houston, Sabrina I., Hud, Nicholas V., Haworth, Ian S., Lieber, Michael R.

“…We found that several major chromosomal fragile sites in human lymphomas, including the bcl-2 major breakpoint region, bcl-1 major translocation cluster, and…”
Get full text

Nitroxide Sensing of a DNA Microenvironment: Mechanistic Insights from EPR Spectroscopy and Molecular Dynamics Simulations by Popova, Anna M, Hatmal, Ma'mon M, Frushicheva, Maria P, Price, Eric A, Qin, Peter Z, Haworth, Ian S

“…The behavior of the nitroxide spin labels 1-oxyl-4-bromo-2,2,5,5-tetramethylpyrroline (R5a) and 1-oxyl-2,2,5,5-tetramethylpyrroline (R5) attached at a…”
Get full text

Antiviral and Immunomodulatory Effects of Phytochemicals from Honey against COVID-19: Potential Mechanisms of Action and Future Directions by Al-Hatamleh, Mohammad A. I., Hatmal, Ma’mon M., Sattar, Kamran, Ahmad, Suhana, Mustafa, Mohd Zulkifli, Bittencourt, Marcelo De Carvalho, Mohamud, Rohimah

“…The new coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has recently put the world under stress,…”
Get full text

Extending the spectrum of CLRN1‐ and ABCA4‐associated inherited retinal dystrophies caused by novel and recurrent variants using exome sequencing by Abu‐Ameerh, Mohammed, Mohammad, Hashim, Dardas, Zain, Barham, Raghda, Ali, Dema, Bijawi, Maysa, Tawalbeh, Mohamed, Amr, Sami, Hatmal, Ma'mon M., Al‐Bdour, Muawyah, Awidi, Abdalla, Azab, Belal

“…Background Inherited retinal dystrophies (IRDs) are characterized by extreme genetic and clinical heterogeneity. There are many genes that are known to cause…”
Get full text

Side Effects and Perceptions Following COVID-19 Vaccination in Jordan: A Randomized, Cross-Sectional Study Implementing Machine Learning for Predicting Severity of Side Effects by Hatmal, Ma’mon M., Al-Hatamleh, Mohammad A. I., Olaimat, Amin N., Hatmal, Malik, Alhaj-Qasem, Dina M., Olaimat, Tamadur M., Mohamud, Rohimah

“…Background: Since the coronavirus disease 2019 (COVID-19) was declared a pandemic, there was no doubt that vaccination is the ideal protocol to tackle it…”
Get full text

Screening the RFX6-DNA binding domain for potential genetic variants in patients with type 2 diabetes by Mahmoud, Ismail Sami, Homsi, Ayat, Al-Ameer, Hamzeh J, Alzyoud, Jihad, Darras, Mais, Shhab, Mohammad Al, Zihlif, Malek, Hatmal, Ma'mon M, Alshaer, Walhan

“…The regulatory factor X6 (RFX6), a member of regulatory factor X family, is known to play a key role in the development and differentiation of pancreatic beta…”
Get full text

Exploring the influence of culture conditions on kefir's anticancer properties by Hatmal, Ma'mon M, Nuirat, Abeer, Zihlif, Malek A, Taha, Mutasem O

“…Cancer is a major health problem in many parts of the world. Conventional anticancer treatments are painful, expensive, and unsafe. Therefore, demand is…”
Get more information

Discovery of new Cdc2-like kinase 4 (CLK4) inhibitors via pharmacophore exploration combined with flexible docking-based ligand/receptor contact fingerprints and machine learning by Al-Tawil, Mai Fayiz, Daoud, Safa, Hatmal, Ma'mon M, Taha, Mutasem Omar

“…Cdc2-like kinase 4 (CLK4) inhibitors are of potential therapeutic value in many diseases particularly cancer. In this study, we combined extensive ligand-based…”
Get full text

Comprehensive Structural and Molecular Comparison of Spike Proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and Their Interactions with ACE2 by Hatmal, Ma'mon M, Alshaer, Walhan, Al-Hatamleh, Mohammad A I, Hatmal, Malik, Smadi, Othman, Taha, Mutasem O, Oweida, Ayman J, Boer, Jennifer C, Mohamud, Rohimah, Plebanski, Magdalena

“…The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has recently emerged in China and caused a disease called coronavirus disease 2019 (COVID-19)…”
Get full text