Search Results - "Hathway, G."

The changing balance of brainstem–spinal cord modulation of pain processing over the first weeks of rat postnatal life by Hathway, G. J., Koch, S., Low, L., Fitzgerald, M.

“…Brainstem–spinal cord connections play an essential role in adult pain processing, and the modulation of spinal pain network excitability by brainstem nuclei…”
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Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain by Kelly, S, Chapman, R J, Woodhams, S, Sagar, D R, Turner, J, Burston, J J, Bullock, C, Paton, K, Huang, J, Wong, A, McWilliams, D F, Okine, B N, Barrett, D A, Hathway, G J, Walsh, D A, Chapman, V

“…Blockade of transient receptor potential vanilloid 1 (TRPV1) with systemic antagonists attenuates osteoarthritis (OA) pain behaviour in rat models, but…”
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Cancer Chemotherapy in Early Life Significantly Alters the Maturation of Pain Processing by Hathway, G.J., Murphy, Emily, Lloyd, Joseph, Greenspon, Charles, Hulse, R.P.

“…•Cisplatin exposure early in life causes delayed but long-lasting mechanical and heat hypersensitivity.•Cisplatin treatment early in life does not lead to…”
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Developmental alterations in noxious-evoked EEG activity recorded from rat primary somatosensory cortex by Devonshire, I.M, Greenspon, C.M, Hathway, G.J

“…Highlights • Resting EEG from primary somatosensory cortex is similar in both adult and juvenile rats. • Evoked EEG activity in response to noxious thermal…”
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A quantification of the relationship between neuronal responses in the rat rostral ventromedial medulla and noxious stimulation-evoked withdrawal reflexes by Devonshire, I. M., Kwok, C. H. T., Suvik, A., Haywood, A. R., Cooper, A. H., Hathway, G. J.

“…The rostral ventromedial medulla (RVM) regulates a range of involuntary behaviours but is most often associated with nociception via the action of…”
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Somatostatin Potently Stimulates In Vivo Striatal Dopamine and γ‐Aminobutyric Acid Release by a Glutamate‐Dependent Action by Hathway, G. J., Emson, P. C., Humphrey, P. P. A., Kendrick, K. M.

“…: We have used in vivo microdialysis in anaesthetised rats to investigate whether somatostatin (SRIF) can play a neuromodulatory role in the striatum. When 100…”
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Somatostatin induces striatal dopamine release and contralateral turning behaviour in the mouse by Hathway, G.J., Humphrey, P.P.A., Kendrick, K.M.

“…Application of somatostatin to the striatum of the anaesthetized rat has previously been shown to elicit large increases in extracellular levels of dopamine…”
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Evidence that somatostatin sst2 receptors mediate striatal dopamine release by Hathway, G J, Humphrey, P P A, Kendrick, K M

“…Somatostatin (SRIF) is a cyclic tetradecapeptide present in medium‐sized aspiny interneurones in the rat striatum. We have previously shown that exogenous SRIF…”
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Somatostatin release by glutamate in vivo is primarily regulated by AMPA receptors by Hathway, G J, Humphrey, P P A, Kendrick, K M

“…We have used in vivo microdialysis in anaesthetized rats to investigate whether levels of striatal somatostatin (SRIF) can be increased in response to…”
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Unveiling the activities of PNPP-19, a toxin-derived synthetic peptide by Freitas, A.C.N., Pacheco, D.F., Lemos, V.S., Carmona, A.K., Peigneur, S., Tytgat, J., Pimenta, A.M., Hathway, G., Cruz, J., Duarte, I.D.G., de Lima, M.E.

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Evidence that somatostatin sst 2 receptors mediate striatal dopamine release by Hathway, G J, Humphrey, P P A, Kendrick, K M

“…Somatostatin (SRIF) is a cyclic tetradecapeptide present in medium‐sized aspiny interneurones in the rat striatum. We have previously shown that exogenous SRIF…”
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Midazolam Potentiates Nociceptive Behavior, Sensitizes Cutaneous Reflexes, and Is Devoid of Sedative Action in Neonatal Rats by KOCH, Stephanie C, FITZGERALD, Maria, HATHWAY, Gareth J

“…The significant postnatal maturation of gamma-aminobutyric acid signaling in the developing brain is likely to have important implications for infant pain…”
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A postnatal switch in GABAergic control of spinal cutaneous reflexes by Hathway, Gareth, Harrop, Emily, Baccei, Mark, Walker, Suellen, Moss, Andrew, Fitzgerald, Maria

“…GABAergic signalling exerts powerful inhibitory control over spinal tactile and nociceptive processing, but during development GABA can be depolarizing and the…”
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Muscle disorders 111. The impact of fatigue in patients with idiopathic inflammatory myopathy: a mixed method study by Campbell, R., Hofmann, D., Hatch, S., Gordon, P., Lempp, H., Das, L., Blumbergs, P., Limaye, V., Vermaak, E., McHugh, N., Edwards, M. H., Jameson, K., Sayer, A. A., Dennison, E., Cooper, C., Salvador, F. B., Huertas, C., Isenberg, D., Jackson, E. J., Middleton, A., Churchill, D., Walker-Bone, K., Worsley, P. R., Mottram, S., Warner, M., Morrissey, D., Gadola, S., Carr, A., Stokes, M., Srivastava, R. N., Sanghi, D., Elbaz, A., Mor, A., Segal, G., Drexler, M., Norman, D., Peled, E., Rozen, N., Goryachev, Y., Debbi, E. M., Haim, A., Wolf, A., Debi, R., Cohen, M. S., Igolnikov, I., Bar Ziv, Y., Benkovich, V., Bernfeld, B., Collins, J., Moots, R. J., Clegg, P. D., Milner, P. I., Ejtehadi, H. D., Nelson, P. N., Wenham, C., Balamoody, S., Hodgson, R., Conaghan, P., Wilkie, R., Blagojevic, M., Jordan, K. P., Mcbeth, J., Peffers, M. J., Beynon, R. J., Thornton, D. J., Chapman, R., Chapman, V., Walsh, D., Kelly, S., Hui, M., Zhang, W., Doherty, S., Rees, F., Muir, K., Maciewicz, R., Doherty, M., Snelling, S., Davidson, R. K., Swingler, T., Price, A., Clark, I., Stockley, E., Hathway, G., Faas, H., Auer, D., Hirsch, G., Hale, E., Kitas, G., Klocke, R., Abraham, A., Pearce, M. S., Mann, K. D., Francis, R. M., Birrell, F., Tucker, M., Mellon, S. J., Jones, L., Price, A. J., Dieppe, P. A., Gill, H. S.

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Lamina‐specific population encoding of cutaneous signals in the spinal dorsal horn using multi‐electrode arrays by Greenspon, Charles M., Battell, Emma E., Devonshire, Ian M., Donaldson, Lucy F., Chapman, Victoria, Hathway, Gareth J.

“…Key points Traditional, widely used in vivo electrophysiological techniques for the investigation of spinal processing of somatosensory information fail to…”
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Evidence that somatostatin sst sub(2) receptors mediate striatal dopamine release by Hathway, G J, Humphrey, PPA, Kendrick, K M

“…Somatostatin (SRIF) is a cyclic tetradecapeptide present in medium-sized aspiny interneurones in the rat striatum. We have previously shown that exogenous SRIF…”
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The changing balance of brainstem–spinal cord modulation of pain processing over the first weeks of rat postnatal life by G. J. Hathway, S. Koch, L. Low, M. Fitzgerald

“…Brainstem–spinal cord connections play an essential role in adult pain processing, and the modulation of spinal pain network excitability by brainstem nuclei…”
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Time course and dose-dependence of nerve growth factor-induced secondary hyperalgesia in the mouse by Hathway, Gareth J, Fitzgerald, Maria

“…Administration of the neurotrophin nerve growth factor (NGF) to rats and humans has been shown to induce both thermal and mechanical hyperalgesia and is used…”
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Identification of somatostatin sst sub(2(a)) receptor expressing neurones in central regions involved in nociception by Schindler, M, Holloway, S, Hathway, G, Woolf, C J, Humphrey, PPA, Emson, P C

“…Somatostatin is a neuromodulator and neurotransmitter in the central nervous system. Administration of somatostatin to the spinal cord or brain areas involved…”
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Somatostatin receptor 2 knockout/lacZ knockin mice show impaired motor coordination and reveal sites of somatostatin action within the striatum by Allen, Jeremy P., Hathway, Gareth J., Clarke, Neil J., Jowett, Mike I., Topps, Stephanie, Kendrick, Keith M., Humphrey, Patrick P. A., Wilkinson, Lawrence S., Emson, Piers C.

“…The peptide somatostatin can modulate the functional output of the basal ganglia. The exact sites and mechanisms of this action, however, are poorly…”
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