Search Results - "Hathaway, Emma"

Immunometabolic Maladaptations to the Tumor Microenvironment by Hathaway, Emma S, Jennings, Erin Q, Rathmell, Jeffrey C

“…Tumors consist of cancer cells and a wide range of tissue resident and infiltrating cell types. Tumor metabolism, however, has largely been studied on whole…”
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Differential Effects of Glutamine Inhibition Strategies on Antitumor CD8 T Cells by Madden, Matthew Z, Ye, Xiang, Chi, Channing, Fisher, Emilie L, Wolf, Melissa M, Needle, Gabriel A, Bader, Jackie E, Patterson, Andrew R, Reinfeld, Bradley I, Landis, Madelyn D, Hathaway, Emma S, Muka, Jason E, O'Neil, Richard T, Karijolich, John, Philip, Mary, Rathmell, Jeffrey C

“…Activated T cells undergo metabolic reprogramming to meet anabolic, differentiation, and functional demands. Glutamine supports many processes in activated T…”
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Obesity induces PD-1 on macrophages to suppress anti-tumour immunity by Bader, Jackie E., Wolf, Melissa M., Lupica-Tondo, Gian Luca, Madden, Matthew Z., Reinfeld, Bradley I., Arner, Emily N., Hathaway, Emma S., Steiner, KayLee K., Needle, Gabriel A., Hatem, Zaid, Landis, Madelyn D., Faneuff, Eden E., Blackman, Amondrea, Wolf, Elysa M., Cottam, Matthew A., Ye, Xiang, Bates, Madison E., Smart, Kyra, Wang, Wenjun, Pinheiro, Laura V., Christofides, Anthos, Smith, DuPreez, Boussiotis, Vassiliki A., Haake, Scott M., Beckermann, Kathryn E., Wellen, Kathryn E., Reinhart-King, Cynthia A., Serezani, C. Henrique, Lee, Cheng-Han, Aubrey, Christa, Chen, Heidi, Rathmell, W. Kimryn, Hasty, Alyssa H., Rathmell, Jeffrey C.

“…Obesity is a leading risk factor for progression and metastasis of many cancers 1 , 2 , yet can in some cases enhance survival 3 – 5 and responses to immune…”
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Author Correction: Obesity induces PD-1 on macrophages to suppress anti-tumour immunity by Bader, Jackie E., Wolf, Melissa M., Lupica-Tondo, Gian Luca, Madden, Matthew Z., Reinfeld, Bradley I., Arner, Emily N., Hathaway, Emma S., Steiner, KayLee K., Needle, Gabriel A., Hatem, Zaid, Landis, Madelyn D., Faneuff, Eden E., Blackman, Amondrea, Wolf, Elysa M., Cottam, Matthew A., Ye, Xiang, Bates, Madison E., Smart, Kyra, Wang, Wenjun, Pinheiro, Laura V., Christofides, Anthos, Smith, DuPreez, Boussiotis, Vassiliki A., Haake, Scott M., Beckermann, Kathryn E., Wellen, Kathryn E., Reinhart-King, Cynthia A., Serezani, C. Henrique, Lee, Cheng-Han, Aubrey, Christa, Chen, Heidi, Rathmell, W. Kimryn, Hasty, Alyssa H., Rathmell, Jeffrey C.

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VHL loss reprograms the immune landscape to promote an inflammatory myeloid microenvironment in renal tumorigenesis by Wolf, Melissa M, Madden, Matthew Z, Arner, Emily N, Bader, Jackie E, Ye, Xiang, Vlach, Logan, Tigue, Megan L, Landis, Madelyn D, Jonker, Patrick B, Hatem, Zaid, Steiner, KayLee K, Gaines, Dakim K, Reinfeld, Bradley I, Hathaway, Emma S, Xin, Fuxue, Tantawy, M Noor, Haake, Scott M, Jonasch, Eric, Muir, Alexander, Weiss, Vivian L, Beckermann, Kathryn E, Rathmell, W Kimryn, Rathmell, Jeffrey C

“…Clear cell renal cell carcinoma (ccRCC) is characterized by dysregulated hypoxia signaling and a tumor microenvironment (TME) highly enriched in myeloid and…”
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High-Throughput Mass Cytometry Staining for Immunophenotyping Clinical Samples by Thrash, Emily M., Kleinsteuber, Katja, Hathaway, Emma S., Nazzaro, Matthew, Haas, Eric, Hodi, F. Stephen, Severgnini, Mariano

“…As mass cytometry (MC) is implemented in clinical settings, the need for robust, validated protocols that reduce batch effects between samples becomes…”
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Phase IB study of ziv-aflibercept plus pembrolizumab in patients with advanced solid tumors by Rahma, Osama E, Tyan, Kevin, Giobbie-Hurder, Anita, Brohl, Andrew S, Bedard, Philippe L, Renouf, Daniel J, Sharon, Elad, Streicher, Howard, Hathaway, Emma, Cunningham, Rachel, Manos, Michael, Severgnini, Mariano, Rodig, Scott, Stephen Hodi, F

“…BackgroundThe combination of antiangiogenic agents with immune checkpoint inhibitors could potentially overcome immune suppression driven by tumor…”
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Simplified mass cytometry protocol for in-plate staining, barcoding, and cryopreservation of human PBMC samples in clinical trials by Abrecht, Charlotte, Hallisey, Margaret, Dennis, Jenna, Nazzaro, Matthew, Brainard, Martha, Hathaway, Emma, Schork, Abigail N., Hodi, F. Stephen, Severgnini, Mariano, Baginska, Joanna

“…With the increasing use of mass cytometry in clinical research, a simplified and standardized protocol for immunophenotyping human peripheral blood mononuclear…”
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374 A phase IB trial of ziv-aflibercept plus pembrolizumab in patients with advanced solid tumors by Tyan, Kevin, Rahma, Osama, Giobbie-Hurder, Anita, Brohl, Andrew, Bedard, Philippe, Renouf, Daniel, Sharon, Elad, Streicher, Howard, Hathaway, Emma, Cunningham, Rachel, Manos, Michael, Severgnini, Mariano, Rodig, Scott, Stephen Hodi, F

“…BackgroundAngiogenic factors play a role in regulating immune suppression in the tumor microenvironment and driving resistance to immune checkpoint inhibitor…”
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Molecular and cellular features of CTLA-4 blockade for relapsed myeloid malignancies after transplantation by Penter, Livius, Zhang, Yi, Savell, Alexandra, Huang, Teddy, Cieri, Nicoletta, Thrash, Emily M., Kim-Schulze, Seunghee, Jhaveri, Aashna, Fu, Jingxin, Ranasinghe, Srinika, Li, Shuqiang, Zhang, Wandi, Hathaway, Emma S., Nazzaro, Matthew, Kim, Haesook T., Chen, Helen, Thurin, Magdalena, Rodig, Scott J., Severgnini, Mariano, Cibulskis, Carrie, Gabriel, Stacey, Livak, Kenneth J., Cutler, Corey, Antin, Joseph H., Nikiforow, Sarah, Koreth, John, Ho, Vincent T., Armand, Philippe, Ritz, Jerome, Streicher, Howard, Neuberg, Donna, Hodi, F. Stephen, Gnjatic, Sacha, Soiffer, Robert J., Liu, X. Shirley, Davids, Matthew S., Bachireddy, Pavan, Wu, Catherine J.

“…Relapsed myeloid disease after allogeneic stem cell transplantation (HSCT) remains largely incurable. We previously demonstrated the potent activity of immune…”
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Differential effects of glutamine inhibition strategies on anti-tumor CD8 T cells by Madden, Matthew Z., Ye, Xiang, Chi, Channing, Fisher, Emilie L., Wolf, Melissa M., Needle, Gabriel A., Bader, Jackie E., Patterson, Andrew R., Reinfeld, Bradley I., Landis, Madelyn D., Hathaway, Emma S., Muka, Jason E., O’Neil, Richard T., Karijolich, John, Philip, Mary, Rathmell, Jeffrey C.

“…Activated T cells undergo metabolic reprogramming to meet anabolic, differentiation, and functional demands. Glutamine supports many processes in activated T…”
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Profiling of Natural Killer Interactions With Cancer Cells Using Mass Cytometry by Hallisey, Margaret, Dennis, Jenna, Gabriel, Elizabeth P., Masciarelli, Alyssa, Chen, Jiajia, Abrecht, Charlotte, Brainard, Martha, Marcotte, William M., Dong, Han, Hathaway, Emma, Tarannum, Mubin, Vergara, Juliana A., Schork, Abigail N., Tyan, Kevin, Tarantino, Giuseppe, Liu, David, Romee, Rizwan, Rahma, Osama E., Severgnini, Mariano, Hodi, F. Stephen, Baginska, Joanna

“…We developed a comprehensive method for functional assessment of the changes in immune populations and killing activity of peripheral blood mononuclear cells…”
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Abstract 6397: Immune profiling for improving responsiveness to ipilimumab plus nivolumab checkpoint blockade treatment in patients with metastatic melanoma by Baginska, Joanna, Chen, Jiajia, Tarantino, Giuseppe, Giobbie-Hurder, Anita, Weirather, Jason L., Severgnini, Mariano, Manos, Michael, Burke, Kelly, Russell, Janice D., Brainard, Martha, Gabriel, Elizabeth, Brennick, Ryan, Nazzaro, Matthew, Hathaway, Emma, Holovatska, Marta, Manuszak, Claire, Ranashinge, Srinika, Liu, David, Hodi, F. Stephen

“…Abstract Background:aCTLA-4 and aPD-1 combination therapy has significantly improved clinical outcomes in patients with metastatic melanoma, with 50%-60% of…”
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