Search Results - "Hatcher, Mark A"

Preparation of Methyltriazolo[1,4]benzodiazepine via Oxidative Activation of a Thiolactam for the Synthesis of BET Inhibitor Molibresib by Erickson, Greg A, Hatcher, Mark A, Journet, Michel, Kowalski, John A, Lovelace, Tom C, Pink, Christopher J, Xie, Shiping

“…A novel oxidative activation of a thiolactam was developed for the preparation of methyltriazolo[1,4]benzodiazepine in a single step. A sulfenic acid (R-SOH)…”
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Copper-Catalyzed Asymmetric Hydrogenation of Aryl and Heteroaryl Ketones by Krabbe, Scott W, Hatcher, Mark A, Bowman, Roy K, Mitchell, Mark B, McClure, Michael S, Johnson, Jeffrey S

“…High throughput screening enabled the development of a Cu-based catalyst system for the asymmetric hydrogenation of prochiral aryl and heteroaryl ketones that…”
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Synthesis of HCV Replicase Inhibitors: Base-Catalyzed Synthesis of Protected α‑Hydrazino Esters and Selective Aerobic Oxidation with Catalytic Pt/Bi/C for Synthesis of Imidazole-4,5-dicarbaldehyde by Bowman, Roy K, Brown, Andrew D, Cobb, Jannine H, Eaddy, John F, Hatcher, Mark A, Leivers, Martin R, Miller, John F, Mitchell, Mark B, Patterson, Daniel E, Toczko, Matthew A, Xie, Shiping

“…A robust convergent synthesis of the prodrugs of HCV replicase inhibitors 1–5 is described. The central 5H-imidazo[4,5-d]pyridazine core was formed from…”
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New Silicon-Mediated, Sequential Ring Expansions of n-Sized 2-Cycloalkenones into Hydroxyolefinic n + m + p Medium-Sized Lactones:  Short Synthesis of (−)-Phoracantholide-J by Posner, Gary H, Hatcher, Mark A, Maio, William A

“…In only four steps from 2-cyclopentenone and 2-cyclohexenone, sequential three- or four-atom and then one- to three-atom ring enlargements produce nine- to…”
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[3,3]-Sigmatropic rearrangements: short, stereocontrolled syntheses of functionalized vitamin D3 side-chain units by Hatcher, Mark A, Posner, Gary H

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Potent, low-calcemic, selective inhibitors of CYP24 hydroxylase: 24-sulfone analogs of the hormone 1α, 25-dihydroxyvitamin D3 by POSNER, Gary H, CRAWFORD, Kenneth R, USERA, Aimee, DOLAN, Patrick M, KENSLER, Thomas W, PELEG, Sara, JONES, Glenville, ZHANG, Anqi, KORCZAK, Bozena, SAHA, Uttam, CHUANG, Samuel S, HONG WOON YANG, KAHRAMAN, Mehmet, HEUNG BAE JEON, LI, Hongbin, JAE KYOO LEE, BYUNG CHUL SUH, HATCHER, Mark A, LABONTE, Tanzina

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A-ring hydroxymethyl 19-nor analogs of the natural hormone 1α, 25-dihydroxyvitamin D3: synthesis and preliminary biological evaluation by HATCHER, Mark A, PELEG, Sara, DOLAN, Patrick, KENSLER, Thomas W, SARJEANT, Amy, POSNER, Gary H

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Copper and silicon mediated, HMPA-free, n+3 ring expansions for the construction of medium sized lactones and lactams: short synthesis of (+)-cis-lauthisan by Posner, Gary H., Hatcher, Mark A., Maio, William A.

“…In this report, several new epoxide examples were united with β-silyl ketone enolates for the construction, after oxidative fragmentation, of ring expanded…”
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[3,3]-Sigmatropic rearrangements: short, stereocontrolled syntheses of functionalized vitamin D 3 side-chain units by Hatcher, Mark A, Posner, Gary H

“…Enantiomerically pure C,D-ring allylic alcohol 4 stereospecifically undergoes five types of [3,4]-sigmatropic rearrangements to give C-23 functionalized 16-ene…”
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New silicon-mediated ring expansion of n-sized conjugated cycloalkenones into homoallylic n+3 lactones by Hatcher, Mark A., Borstnik, Kristina, Posner, Gary H.

“…Silicon nucleophilic β-addition to various 2-cycloalkenones, followed ultimately by mild and rapid α-alkylation of the corresponding cycloalkanone enolates…”
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A-ring hydroxymethyl 19-nor analogs of the natural hormone 1alpha,25-dihydroxyvitamin D(3): synthesis and preliminary biological evaluation by Hatcher, Mark A, Peleg, Sara, Dolan, Patrick, Kensler, Thomas W, Sarjeant, Amy, Posner, Gary H

“…A series 5-8 of 1- and 3-CH(2)OH 19-nor analogs of the hormone calcitriol (1) has been prepared. Surprisingly, 19-nor 1alpha-CH(2)OH analog 5a is more…”
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A-ring hydroxymethyl 19-nor analogs of the natural hormone 1α,25-dihydroxyvitamin D 3: synthesis and preliminary biological evaluation by Hatcher, Mark A., Peleg, Sara, Dolan, Patrick, Kensler, Thomas W., Sarjeant, Amy, Posner, Gary H.

“…[Display omitted] A series 5– 8 of 1- and 3-CH 2OH 19-nor analogs of the hormone calcitriol ( 1) has been prepared. Surprisingly, 19-nor 1α-CH 2OH analog 5a is…”
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Potent, low-calcemic, selective inhibitors of CYP24 hydroxylase: 24-sulfone analogs of the hormone 1α,25-dihydroxyvitamin D 3 by Posner, Gary H., Crawford, Kenneth R., Yang, Hong Woon, Kahraman, Mehmet, Jeon, Heung Bae, Li, Hongbin, Lee, Jae Kyoo, Suh, Byung Chul, Hatcher, Mark A., Labonte, Tanzina, Usera, Aimee, Dolan, Patrick M., Kensler, Thomas W., Peleg, Sara, Jones, Glenville, Zhang, Anqi, Korczak, Bozena, Saha, Uttam, Chuang, Samuel S.

“…The new 24-phenylsulfone 4a, a low-calcemic analog of the natural hormone 1α,25-dihydroxyvitamin D 3, is a potent (IC 50 = 28 nM) and highly selective…”
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Potent, low-calcemic, selective inhibitors of CYP24 hydroxylase: 24-sulfone analogs of the hormone 1alpha,25-dihydroxyvitamin D3 by Posner, Gary H, Crawford, Kenneth R, Yang, Hong Woon, Kahraman, Mehmet, Jeon, Heung Bae, Li, Hongbin, Lee, Jae Kyoo, Suh, Byung Chul, Hatcher, Mark A, Labonte, Tanzina, Usera, Aimee, Dolan, Patrick M, Kensler, Thomas W, Peleg, Sara, Jones, Glenville, Zhang, Anqi, Korczak, Bozena, Saha, Uttam, Chuang, Samuel S

“…The new 24-phenylsulfone 4a, a low-calcemic analog of the natural hormone 1alpha,25-dihydroxyvitamin D(3), is a potent (IC(50) = 28nM) and highly selective…”
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