Search Results - "Hatch, Nathan D."

The iron-dependent repressor YtgR is a tryptophan-dependent attenuator of the trpRBA operon in Chlamydia trachomatis by Pokorzynski, Nick D., Hatch, Nathan D., Ouellette, Scot P., Carabeo, Rey A.

“…The trp operon of Chlamydia trachomatis is organized differently from other model bacteria. It contains trpR , an intergenic region (IGR), and the biosynthetic…”
Get full text

Identification of the alternative sigma factor regulons of Chlamydia trachomatis using multiplexed CRISPR interference by Hatch, Nathan D, Ouellette, Scot P

“…is a developmentally regulated, obligate intracellular bacterium that encodes three sigma factors: σ66, σ54, and σ28. σ66 is the major sigma factor controlling…”
Get full text

Codon-Dependent Transcriptional Changes in Response to Tryptophan Limitation in the Tryptophan Auxotrophic Pathogens Chlamydia trachomatis and Streptococcus pyogenes by Ouellette, Scot P, Hatch, Nathan D, Wood, Nicholas A, Herrera, Andrea L, Chaussee, Michael S

“…Chlamydia trachomatis and Streptococcus pyogenes are among the most prevalent bacterial pathogens of humans. Interestingly, both pathogens are tryptophan (Trp)…”
Get full text

CRISPR Interference To Inducibly Repress Gene Expression in Chlamydia trachomatis by Ouellette, Scot P, Blay, Emmanuel A, Hatch, Nathan D, Fisher-Marvin, Laura A

“…The ability to inducibly repress gene expression is critical to the study of organisms, like Chlamydia, with reduced genomes in which the majority of genes are…”
Get full text

Inhibition of tRNA Synthetases Induces Persistence in Chlamydia by Hatch, Nathan D, Ouellette, Scot P

“…is the leading cause of bacterial sexually transmitted infections, and causes community-acquired respiratory infections. , the host immune system will release…”
Get full text

A novel approach to eliminate therapy-resistant mantle cell lymphoma: synergistic effects of Vorinostat with Palbociclib by Chaturvedi, Nagendra K., Hatch, Nathan D., Sutton, Garrett L., Kling, Matthew, Vose, Julie M., Joshi, Shantaram S.

“…Mantle cell lymphoma (MCL) represents an aggressive B-cell lymphoma with frequent relapse and poor survival. Recently, dysregulated histone-deacetylases…”
Get full text

Abstract 4051: Combination efficacy of HDAC inhibitor vorinostat and CDK-4/6 dual inhibitor palbociclib against therapy-resistant mantle cell lymphoma by Chaturvedi, Nagendra K., Hatch, Nathan D., Sutton, Garrett L., Kling, Matthew J., Vose, Julie M., Joshi, Shantaram S.

“…Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma accounting for about 7% of all non-Hodgkins lymphoma. While multiple therapy regimens are available…”
Get full text