Search Results - "Hatch, Michaela M"

Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis by Hultgren, Nan W., Fang, Jennifer S., Ziegler, Mary E., Ramirez, Ricardo N., Phan, Duc T. T., Hatch, Michaela M. S., Welch-Reardon, Katrina M., Paniagua, Antonio E., Kim, Lin S., Shon, Nathan N., Williams, David S., Mortazavi, Ali, Hughes, Christopher C. W.

“…Slug ( SNAI2 ), a member of the well-conserved Snail family of transcription factors, has multiple developmental roles, including in epithelial-to-mesenchymal…”
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IL-33 induction and signaling are controlled by glutaredoxin-1 in mouse macrophages by Weinberg, Ellen O, Ferran, Beatriz, Tsukahara, Yuko, Hatch, Michaela M S, Han, Jingyan, Murdoch, Colin E, Matsui, Reiko

“…Interleukin (IL)-33 is an interleukin-1 like cytokine that enhances Th2 responses and mediates mucosal immunity and allergic inflammation but the mechanism…”
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mTORC2 mediates CXCL12-induced angiogenesis by Ziegler, Mary E., Hatch, Michaela M. S., Wu, Nan, Muawad, Steven A., Hughes, Christopher C. W.

“…The chemokine CXCL12, through its receptor CXCR4, positively regulates angiogenesis by promoting endothelial cell (EC) migration and tube formation. However,…”
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Phosphatidylserine-targeting antibodies augment the anti-tumorigenic activity of anti-PD-1 therapy by enhancing immune activation and downregulating pro-oncogenic factors induced by T-cell checkpoint inhibition in murine triple-negative breast cancers by Gray, Michael J, Gong, Jian, Hatch, Michaela M S, Nguyen, Van, Hughes, Christopher C W, Hutchins, Jeff T, Freimark, Bruce D

“…The purpose of this study was to investigate the potential of antibody-directed immunotherapy targeting the aminophospholipid phosphatidylserine, which…”
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Recapitulating the human tumor microenvironment: Colon tumor-derived extracellular matrix promotes angiogenesis and tumor cell growth by Romero-López, Mónica, Trinh, Andrew L, Sobrino, Agua, Hatch, Michaela M.S, Keating, Mark T, Fimbres, Cristhian, Lewis, David E, Gershon, Paul D, Botvinick, Elliot L, Digman, Michelle, Lowengrub, John S, Hughes, Christopher C.W

“…Abstract Extracellular matrix (ECM) is an essential and dynamic component of all tissues and directly affects cellular behavior by providing both mechanical…”
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An in vitro vascularized micro-tumor model of human colorectal cancer recapitulates in vivo responses to standard-of-care therapy by Hachey, Stephanie J, Movsesyan, Silva, Nguyen, Quy H, Burton-Sojo, Giselle, Tankazyan, Ani, Wu, Jie, Hoang, Tuyen, Zhao, Da, Wang, Shuxiong, Hatch, Michaela M, Celaya, Elizabeth, Gomez, Samantha, Chen, George T, Davis, Ryan T, Nee, Kevin, Pervolarakis, Nicholas, Lawson, Devon A, Kessenbrock, Kai, Lee, Abraham P, Lowengrub, John, Waterman, Marian L, Hughes, Christopher C W

“…Around 95% of anti-cancer drugs that show promise during preclinical study fail to gain FDA-approval for clinical use. This failure of the preclinical pipeline…”
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Deconstructing Allograft Adipose and Fascia Matrix: Fascia Matrix Improves Angiogenesis, Volume Retention, and Adipogenesis in a Rodent Model by Ziegler, Mary E., Sorensen, Alexandria M., Banyard, Derek A., Sayadi, Lohrasb R., Chnari, Evangelia, Hatch, Michaela M., Tassey, Jade, Mirzakhanyan, Yeva, Gershon, Paul D., Hughes, Christopher C. W., Evans, Gregory R. D., Widgerow, Alan D.

“…Autologous fat grafting is commonly used for soft-tissue repair (approximately 90,000 cases per year in the United States), but outcomes are limited by volume…”
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A vascularized 3D model of the human pancreatic islet for ex vivo study of immune cell-islet interaction by Bender, R Hugh F, O'Donnell, Benjamen T, Shergill, Bhupinder, Pham, Brittany Q, Tahmouresie, Sima, Sanchez, Celeste N, Juat, Damie J, Hatch, Michaela M S, Shirure, Venktesh S, Wortham, Matthew, Nguyen-Ngoc, Kim-Vy, Jun, Yesl, Gaetani, Roberto, Christman, Karen L, Teyton, Luc, George, Steven C, Sander, Maike, Hughes, Christopher C W

“…Insulin is an essential regulator of blood glucose homeostasis that is produced exclusively by cells within the pancreatic islets of healthy individuals. In…”
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Antibody-Mediated Phosphatidylserine Blockade Enhances the Antitumor Responses to CTLA-4 and PD-1 Antibodies in Melanoma by Freimark, Bruce D, Gong, Jian, Ye, Dan, Gray, Michael J, Nguyen, Van, Yin, Shen, Hatch, Michaela M S, Hughes, Christopher C W, Schroit, Alan J, Hutchins, Jeff T, Brekken, Rolf A, Huang, Xianming

“…In tumor-bearing animals, the membrane phospholipid phosphatidylserine (PS) suppresses immune responses, suggesting that PS signaling could counteract the…”
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Deconstructing Allograft Adipose and Fascia Matrix to Treat Soft Tissue Defects: The Addition of Fascia Matrix to Adipose Matrix Improves Angiogenesis, Volume Retention and Adipogenesis in a Rodent Model by Ziegler, Mary E., Sorensen, Alexandria M., Banyard, Derek A., Sayadi, Lohrasb R., Chnari, Evangelia, Hatch, Michaela M., Tassey, Jade, Mirzakhanyan, Yeva, Gershon, Paul D., Hughes, Christopher C.W., Evans, Gregory R.D., Widgerow, Alan D.

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Antibody mediated blockade of phosphatidylserine to enhance immune checkpoint blockade by repolarizing immune suppressive mechanisms of the tumor microenvironment by Hutchins, Jeff, Gray, Michael J, Huang, Xianming, Gong, Jian, Hatch, Michaela MS, Nguyen, Van, Hughes, Christopher C.W., Brekken, Rolf A., Freimark, Bruce D, Gerber, David E.

“…Abstract only…”
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