Search Results - "Hatayama, Minoru"

Developmental control of noradrenergic system by SLITRK1 and its implications in the pathophysiology of neuropsychiatric disorders by Hatayama, Minoru, Aruga, Jun

“…SLITRK1 is a neuronal transmembrane protein with neurite development-and synaptic formation-controlling abilities. Several rare variants of SLITRK1 have been…”
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Dysregulation of erythropoiesis and altered erythroblastic NMDA receptor-mediated calcium influx in Lrfn2-deficient mice by Maekawa, Ryuta, Muto, Hideki, Hatayama, Minoru, Aruga, Jun

“…LRFN2 encodes a synaptic adhesion-like molecule that physically interacts with N-methyl-D-aspartate (NMDA) receptor 1 and its scaffold proteins. Previous…”
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Autism-like behaviours and enhanced memory formation and synaptic plasticity in Lrfn2/SALM1-deficient mice by Morimura, Naoko, Yasuda, Hiroki, Yamaguchi, Kazuhiko, Katayama, Kei-ichi, Hatayama, Minoru, Tomioka, Naoko H., Odagawa, Maya, Kamiya, Akiko, Iwayama, Yoshimi, Maekawa, Motoko, Nakamura, Kazuhiko, Matsuzaki, Hideo, Tsujii, Masatsugu, Yamada, Kazuyuki, Yoshikawa, Takeo, Aruga, Jun

“…Lrfn2/SALM1 is a PSD-95-interacting synapse adhesion molecule, and human LRFN2 is associated with learning disabilities. However its role in higher brain…”
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Link between the causative genes of holoprosencephaly: Zic2 directly regulates Tgif1 expression by Ishiguro, Akira, Hatayama, Minoru, Otsuka, Maky I., Aruga, Jun

“…One of the causal genes for holoprosencephaly (HPE) is ZIC2 (HPE5). It belongs to the zinc finger protein of the cerebellum (Zic) family of genes that share a…”
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Identification and Characterization of Novel Conserved Domains in Metazoan Zic Proteins by Tohmonda, Takahide, Kamiya, Akiko, Ishiguro, Akira, Iwaki, Takashi, Fujimi, Takahiko J, Hatayama, Minoru, Aruga, Jun

“…Zic family genes encode C2H2-type zinc finger proteins that act as critical toolkit proteins in the metazoan body plan establishment. In this study, we…”
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Characterization of the tandem CWCH2 sequence motif: a hallmark of inter-zinc finger interactions by Hatayama, Minoru, Aruga, Jun

“…The C2H2 zinc finger (ZF) domain is widely conserved among eukaryotic proteins. In Zic/Gli/Zap1 C2H2 ZF proteins, the two N-terminal ZFs form a single…”
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Leucine-Rich Repeats and Transmembrane Domain 2 Controls Protein Sorting in the Striatal Projection System and Its Deficiency Causes Disturbances in Motor Responses and Monoamine Dynamics by Ichise, Misato, Sakoori, Kazuto, Katayama, Kei-Ichi, Morimura, Naoko, Yamada, Kazuyuki, Ozawa, Hiroki, Matsunaga, Hayato, Hatayama, Minoru, Aruga, Jun

“…The striatum is involved in action selection, and its disturbance can cause movement disorders. Here, we show that leucine-rich repeats and transmembrane…”
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Expression of ZIC family genes in meningiomas and other brain tumors by Aruga, Jun, Nozaki, Yayoi, Hatayama, Minoru, Odaka, Yuri S, Yokota, Naoki

“…Zic zinc finger proteins are present in the developing rodent meninges and are required for cell proliferation and differentiation of meningeal progenitors…”
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SLITRK1-mediated noradrenergic projection suppression in the neonatal prefrontal cortex by Hatayama, Minoru, Katayama, Kei-ichi, Kawahara, Yukie, Matsunaga, Hayato, Takashima, Noriko, Iwayama, Yoshimi, Matsumoto, Yoshifumi, Nishi, Akinori, Yoshikawa, Takeo, Aruga, Jun

“…SLITRK1 is an obsessive-compulsive disorder spectrum-disorders-associated gene that encodes a neuronal transmembrane protein. Here we show that SLITRK1…”
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IP3 signaling is required for cilia formation and left-right body axis determination in Xenopus embryos by Hatayama, Minoru, Mikoshiba, Katsuhiko, Aruga, Jun

“…Vertebrate left-right (LR) body axis is manifested as an asymmetrical alignment of the internal organs such as the heart and the gut. It has been proposed that…”
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Functional and structural basis of the nuclear localization signal in the ZIC3 zinc finger domain by Hatayama, Minoru, Tomizawa, Tadashi, Sakai-Kato, Kumiko, Bouvagnet, Patrice, Kose, Shingo, Imamoto, Naoko, Yokoyama, Shigeyuki, Utsunomiya-Tate, Naoko, Mikoshiba, Katsuhiko, Kigawa, Takanori, Aruga, Jun

“…Disruptions in ZIC3 cause heterotaxy, a congenital anomaly of the left–right axis. ZIC3 encodes a nuclear protein with a zinc finger (ZF) domain that contains…”
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Zic2 hypomorphic mutant mice as a schizophrenia model and ZIC2 mutations identified in schizophrenia patients by Hatayama, Minoru, Ishiguro, Akira, Iwayama, Yoshimi, Takashima, Noriko, Sakoori, Kazuto, Toyota, Tomoko, Nozaki, Yayoi, Odaka, Yuri S., Yamada, Kazuyuki, Yoshikawa, Takeo, Aruga, Jun

“…ZIC2 is a causal gene for holoprosencephaly and encodes a zinc-finger-type transcriptional regulator. We characterized Zic2 kd/+ mice with a moderate (40%)…”
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Apoptosis in skin pigment cells of the medaka, Oryzias latipes (Teleostei), during long-term chromatic adaptation: the role of sympathetic innervation by Sugimoto, M, Uchida, N, Hatayama, M

“…Many teleost fish can adapt their body color to a background color by changing the morphology and density of their skin pigment cells. Melanophore density in…”
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Xenopus Zic3 controls notochord and organizer development through suppression of the Wnt/β-catenin signaling pathway by Fujimi, Takahiko J., Hatayama, Minoru, Aruga, Jun

“…Zic3 controls neuroectodermal differentiation and left–right patterning in Xenopus laevis embryos. Here we demonstrate that Zic3 can suppress Wnt/β-catenin…”
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Xenopus Brachyury regulates mesodermal expression of Zic3, a gene controlling left–right asymmetry by Kitaguchi, Tetsuya, Mizugishi, Kiyomi, Hatayama, Minoru, Aruga, Jun, Mikoshiba, Katsuhiko

“…The Brachyury gene has a critical role in the formation of posterior mesoderm and notochord in vertebrate development. A recent study showed that Brachyury is…”
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Elfn1 recruits presynaptic mGluR7 in trans and its loss results in seizures by Tomioka, Naoko H., Yasuda, Hiroki, Miyamoto, Hiroyuki, Hatayama, Minoru, Morimura, Naoko, Matsumoto, Yoshifumi, Suzuki, Toshimitsu, Odagawa, Maya, Odaka, Yuri S., Iwayama, Yoshimi, Won Um, Ji, Ko, Jaewon, Inoue, Yushi, Kaneko, Sunao, Hirose, Shinichi, Yamada, Kazuyuki, Yoshikawa, Takeo, Yamakawa, Kazuhiro, Aruga, Jun

“…GABAergic interneurons are highly heterogeneous, and much is unknown about the specification and functional roles of their neural circuits. Here we show that a…”
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GLI PROTEIN NUCLEAR LOCALIZATION SIGNAL: Hedgehog Signaling by HATAYAMA, Minoru, ARUGA, Jun

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Gli Protein Nuclear Localization Signal by Hatayama, Minoru, Aruga, Jun

“…Drosophila cubitus interruptus (Ci) and its vertebrate homologues, the glioblastoma (Gli) protein family, are the transcription factors belonging to the…”
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Xenopus Zic3 controls notochord and organizer development through suppression of the Wnt/I2-catenin signaling pathway by Fujimi, Takahiko J, Hatayama, Minoru, Aruga, Jun

“…Zic3 controls neuroectodermal differentiation and left-right patterning in Xenopus laevis embryos. Here we demonstrate that Zic3 can suppress Wnt/ beta…”
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Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives by Inoue, Takashi, Hatayama, Minoru, Tohmonda, Takahide, Itohara, Shigeyoshi, Aruga, Jun, Mikoshiba, Katsuhiko

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