Search Results - "Hatano, Noriyuki"
-
1
PIEZO1 and TRPV4, which Are Distinct Mechano-Sensors in the Osteoblastic MC3T3-E1 Cells, Modify Cell-Proliferation
Published in International journal of molecular sciences (08-10-2019)“…Mechanical-loading and unloading can modify osteoblast functioning. Ca signaling is one of the earliest events in osteoblasts to induce a mechanical stimulus,…”
Get full text
Journal Article -
2
Potent Activation of Human but Not Mouse TRPA1 by JT010
Published in International journal of molecular sciences (18-11-2022)“…Transient receptor potential (TRP) ankyrin repeat 1 (TRPA1), which is involved in inflammatory pain sensation, is activated by endogenous factors, such as…”
Get full text
Journal Article -
3
HIF-1α Dependent Upregulation of ZIP8, ZIP14, and TRPA1 Modify Intracellular Zn2+ Accumulation in Inflammatory Synoviocytes
Published in International journal of molecular sciences (14-06-2021)“…Intracellular free zinc ([Zn2+]i) is mobilized in neuronal and non-neuronal cells under physiological and/or pathophysiological conditions; therefore, [Zn2+]i…”
Get full text
Journal Article -
4
PIEZO1 Channel Is a Potential Regulator of Synovial Sarcoma Cell-Viability
Published in International journal of molecular sciences (14-05-2018)“…Detection of mechanical stress is essential for diverse biological functions including touch, audition, and maintenance of vascular myogenic tone. PIEZO1, a…”
Get full text
Journal Article -
5
The inflammatory regulation of TRPA1 expression in human A549 lung epithelial cells
Published in Pulmonary pharmacology & therapeutics (01-10-2021)“…Transient receptor potential ankyrin-1 (TRPA1) is an ion channel mediating pain and cough signals in sensory neurons. We and others have shown that TRPA1 is…”
Get full text
Journal Article -
6
TRPV4 partially participates in proliferation of human brain capillary endothelial cells
Published in Life sciences (1973) (12-03-2013)“…The vanilloid type 4 transient receptor potential channel (TRPV4) is a potential environmental sensor to multiple stimuli in many types of cells. In this…”
Get full text
Journal Article -
7
Na+ entry through heteromeric TRPC4/C1 channels mediates (−)Englerin A-induced cytotoxicity in synovial sarcoma cells
Published in Scientific reports (05-12-2017)“…The sesquiterpene (−)Englerin A (EA) is an organic compound from the plant Phyllanthus engleri which acts via heteromeric TRPC4/C1 channels to cause…”
Get full text
Journal Article -
8
Stimulation of human TRPA1 channels by clinical concentrations of the antirheumatic drug auranofin
Published in American Journal of Physiology: Cell Physiology (15-02-2013)“…Gold compounds, which were widely used to treat rheumatoid arthritis, have been recently used as experimental agents for tumor treatment. Transient receptor…”
Get more information
Journal Article -
9
Downregulation of Ca2+-activated Cl- channel TMEM16A by the inhibition of histone deacetylase in TMEM16A-expressing cancer cells
Published in The Journal of pharmacology and experimental therapeutics (01-12-2014)“…The Ca(2+)-activated Cl(-) channel transmembrane proteins with unknown function 16 A (TMEM16A; also known as anoctamin 1 or discovered on gastrointestinal…”
Get more information
Journal Article -
10
Castration Induces Down-Regulation of A-Type K + Channel in Rat Vas Deferens Smooth Muscle
Published in International journal of molecular sciences (21-08-2019)“…A-type K channels contribute to regulating the propagation and frequency of action potentials in smooth muscle cells (SMCs). The present study (i) identified…”
Get full text
Journal Article -
11
Accelerated Ca2+ entry by membrane hyperpolarization due to Ca2+-activated K+ channel activation in response to histamine in chondrocytes
Published in American Journal of Physiology: Cell Physiology (01-04-2010)“…In articular cartilage inflammation, histamine release from mast cells is a key event. It can enhance cytokine production and matrix synthesis and also promote…”
Get more information
Journal Article -
12
The NADPH oxidase inhibitor diphenyleneiodonium activates the human TRPA1 nociceptor
Published in American Journal of Physiology: Cell Physiology (15-08-2014)“…Transient receptor potential ankyrin 1 (TRPA1) is a Ca(2+)-permeable nonselective cation channel expressed in neuronal and nonneuronal cells and plays an…”
Get more information
Journal Article -
13
An environmental sensor, TRPV4 is a novel regulator of intracellular Ca2+ in human synoviocytes
Published in American Journal of Physiology: Cell Physiology (01-11-2009)“…The activation of a vanilloid type 4 transient receptor potential channel (TRPV4) has an obligatory role in regulation of intracellular Ca(2+) (Ca(2+)(i)) in…”
Get more information
Journal Article -
14
Oseltamivir Blocks Human Neuronal Nicotinic Acetylcholine Receptor‐Mediated Currents
Published in Basic & clinical pharmacology & toxicology (01-02-2015)“…The effects of oseltamivir, a neuraminidase inhibitor, were tested on the function of neuronal nicotinic acetylcholine receptors (nAChRs) in a neuroblastoma…”
Get full text
Journal Article -
15
An environmental pollutant, 9,10‐phenanthrenequinone, activates human TRPA1 via critical cysteines 621 and 665
Published in Pharmacology research & perspectives (01-08-2017)“…Transient receptor potential ankyrin 1 (TRPA1) is activated by noxious cold, mechanical stimulation, and irritant chemicals. In our recent study, 9,…”
Get full text
Journal Article -
16
Diclofenac, a nonsteroidal anti‐inflammatory drug, is an antagonist of human TRPM3 isoforms
Published in Pharmacology research & perspectives (01-06-2016)“…The effects of diclofenac (Dic), an acetic acid derivative‐type nonsteroidal anti‐inflammatory drug, were examined on the function of transient receptor…”
Get full text
Journal Article -
17
Molecular Cloning and Characterization of CALP/KChIP4, a Novel EF-hand Protein Interacting with Presenilin 2 and Voltage-gated Potassium Channel Subunit Kv4
Published in The Journal of biological chemistry (26-04-2002)“…Presenilin (PS) genes linked to early-onset familial Alzheimer's disease encode polytopic membrane proteins that are presumed to constitute the catalytic…”
Get full text
Journal Article -
18
TRPV4-Like Non-selective Cation Currents in Cultured Aortic Myocytes
Published in Journal of Pharmacological Sciences (2008)“…In this study, we provide evidence of critical changes in the expression of non-selective cation currents (NSCC) during culture in rat aortic myocytes. A…”
Get full text
Journal Article -
19
Activation of large-conductance, Ca2+-activated K+ channels by cannabinoids
Published in American Journal of Physiology: Cell Physiology (01-01-2006)“…We have examined the effects of the cannabinoid anandamide (AEA) and its stable analog, methanandamide (methAEA), on large-conductance, Ca2+-activated K+ (BK)…”
Get more information
Journal Article -
20
Cell-Culture–Dependent Change of Ca2+ Response of Rat Aortic Myocytes to Sphingosine-1-Phosphate
Published in Journal of Pharmacological Sciences (2008)“…We characterized the effects of sphingosine-1-phosphate (S1P) on rat aortic myocytes with or without culture. Application of S1P induced a small Ca2+ response…”
Get full text
Journal Article