Search Results - "Hata, N"

The BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer Therapeutics by Hata, Aaron N, Engelman, Jeffrey A, Faber, Anthony C

“…The ability of cancer cells to suppress apoptosis is critical for carcinogenesis. The BCL2 family proteins comprise the sentinel network that regulates the…”
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Targeting oncogenic drivers in lung cancer: Recent progress, current challenges and future opportunities by Yoda, Satoshi, Dagogo-Jack, Ibiayi, Hata, Aaron N.

“…Targeted therapies have changed the landscape of treatments for non-small cell lung cancer (NSCLC). Specific targeted therapies have been approved for NSCLC…”
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Targeting FGFR overcomes EMT-mediated resistance in EGFR mutant non-small cell lung cancer by Raoof, Sana, Mulford, Iain J., Frisco-Cabanos, Heidie, Nangia, Varuna, Timonina, Daria, Labrot, Emma, Hafeez, Nafeeza, Bilton, Samantha J., Drier, Yotam, Ji, Fei, Greenberg, Max, Williams, August, Kattermann, Krystina, Damon, Leah, Sovath, Sosathya, Rakiec, Daniel P., Korn, Joshua M., Ruddy, David A., Benes, Cyril H., Hammerman, Peter S., Piotrowska, Zofia, Sequist, Lecia V., Niederst, Matthew J., Barretina, Jordi, Engelman, Jeffrey A., Hata, Aaron N.

“…Evolved resistance to tyrosine kinase inhibitor (TKI)-targeted therapies remains a major clinical challenge. In epidermal growth factor receptor ( EGFR )…”
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Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation by Hata, Aaron N, Breyer, Richard M

“…Prostaglandins are lipid-derived autacoids that modulate many physiological systems including the CNS, cardiovascular, gastrointestinal, genitourinary,…”
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The new-generation selective ROS1/NTRK inhibitor DS-6051b overcomes crizotinib resistant ROS1-G2032R mutation in preclinical models by Katayama, Ryohei, Gong, Bo, Togashi, Noriko, Miyamoto, Masaya, Kiga, Masaki, Iwasaki, Shiho, Kamai, Yasuki, Tominaga, Yuichi, Takeda, Yasuyuki, Kagoshima, Yoshiko, Shimizu, Yuki, Seto, Yosuke, Oh-hara, Tomoko, Koike, Sumie, Nakao, Naoki, Hanzawa, Hiroyuki, Watanabe, Kengo, Yoda, Satoshi, Yanagitani, Noriko, Hata, Aaron N., Shaw, Alice T., Nishio, Makoto, Fujita, Naoya, Isoyama, Takeshi

“…ROS1 gene rearrangement was observed in around 1–2 % of NSCLC patients and in several other cancers such as cholangiocarcinoma, glioblastoma, or colorectal…”
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Impact of EML4-ALK Variant on Resistance Mechanisms and Clinical Outcomes in ALK-Positive Lung Cancer by Lin, Jessica J, Zhu, Viola W, Yoda, Satoshi, Yeap, Beow Y, Schrock, Alexa B, Dagogo-Jack, Ibiayi, Jessop, Nicholas A, Jiang, Ginger Y, Le, Long P, Gowen, Kyle, Stephens, Philip J, Ross, Jeffrey S, Ali, Siraj M, Miller, Vincent A, Johnson, Melissa L, Lovly, Christine M, Hata, Aaron N, Gainor, Justin F, Iafrate, Anthony J, Shaw, Alice T, Ou, Sai-Hong Ignatius

“…Purpose Advanced anaplastic lymphoma kinase ( ALK) fusion-positive non-small-cell lung cancers (NSCLCs) are effectively treated with ALK tyrosine kinase…”
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MET Alterations Are a Recurring and Actionable Resistance Mechanism in ALK-Positive Lung Cancer by Dagogo-Jack, Ibiayi, Yoda, Satoshi, Lennerz, Jochen K, Langenbucher, Adam, Lin, Jessica J, Rooney, Marguerite M, Prutisto-Chang, Kylie, Oh, Audris, Adams, Nathaniel A, Yeap, Beow Y, Chin, Emily, Do, Andrew, Marble, Hetal D, Stevens, Sara E, Digumarthy, Subba R, Saxena, Ashish, Nagy, Rebecca J, Benes, Cyril H, Azzoli, Christopher G, Lawrence, Michael S, Gainor, Justin F, Shaw, Alice T, Hata, Aaron N

“…Most -positive lung cancers will develop ALK-independent resistance after treatment with next-generation ALK inhibitors. amplification has been described in…”
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Synthetic Lethal Interaction of Combined BCL-XL and MEK Inhibition Promotes Tumor Regressions in KRAS Mutant Cancer Models by Corcoran, Ryan B., Cheng, Katherine A., Hata, Aaron N., Faber, Anthony C., Ebi, Hiromichi, Coffee, Erin M., Greninger, Patricia, Brown, Ronald D., Godfrey, Jason T., Cohoon, Travis J., Song, Youngchul, Lifshits, Eugene, Hung, Kenneth E., Shioda, Toshi, Dias-Santagata, Dora, Singh, Anurag, Settleman, Jeffrey, Benes, Cyril H., Mino-Kenudson, Mari, Wong, Kwok-Kin, Engelman, Jeffrey A.

“…KRAS is the most commonly mutated oncogene, yet no effective targeted therapies exist for KRAS mutant cancers. We developed a pooled shRNA-drug screen strategy…”
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Stitchr: stitching coding TCR nucleotide sequences from V/J/CDR3 information by Heather, James M, Spindler, Matthew J, Alonso, Marta Herrero, Shui, Yifang Ivana, Millar, David G, Johnson, David S, Cobbold, Mark, Hata, Aaron N

“…Abstract The study and manipulation of T cell receptors (TCRs) is central to multiple fields across basic and translational immunology research. Produced by…”
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Acquired Resistance of EGFR-Mutated Lung Cancer to Tyrosine Kinase Inhibitor Treatment Promotes PARP Inhibitor Sensitivity by Marcar, Lynnette, Bardhan, Kankana, Gheorghiu, Liliana, Dinkelborg, Patrick, Pfäffle, Heike, Liu, Qi, Wang, Meng, Piotrowska, Zofia, Sequist, Lecia V., Borgmann, Kerstin, Settleman, Jeffrey E., Engelman, Jeffrey A., Hata, Aaron N., Willers, Henning

“…Lung cancers with oncogenic mutations in the epidermal growth factor receptor (EGFR) invariably acquire resistance to tyrosine kinase inhibitor (TKI)…”
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Cotargeting a MYC/eIF4A-survival axis improves the efficacy of KRAS inhibitors in lung cancer by Nardi, Francesca, Perurena, Naiara, Schade, Amy E, Li, Ze-Hua, Ngo, Kenneth, Ivanova, Elena V, Saldanha, Aisha, Li, Chendi, Gokhale, Prafulla C, Hata, Aaron N, Barbie, David A, Paweletz, Cloud P, Jänne, Pasi A, Cichowski, Karen

“…Despite the success of KRAS G12C inhibitors in non-small cell lung cancer (NSCLC), more effective treatments are needed. One preclinical strategy has been to…”
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Effect of continuous lighting on the growth and leaf chemical components of Artemisia princeps grown hydroponically in a plant factory condition by Hata, N, Kawamura, M

“…Young leaves of Artemisia princeps Pamp. (Japanese mugwort), already used as a foodstuff in Japan, can be positioned as a functional health food because of…”
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Increased Synthesis of MCL-1 Protein Underlies Initial Survival of EGFR -Mutant Lung Cancer to EGFR Inhibitors and Provides a Novel Drug Target by Song, Kyung-A, Hosono, Yasuyuki, Turner, Crystal, Jacob, Sheeba, Lochmann, Timothy L, Murakami, Yoshiko, Patel, Neha U, Ham, Jungoh, Hu, Bin, Powell, Krista M, Coon, Colin M, Windle, Brad E, Oya, Yuko, Koblinski, Jennifer E, Harada, Hisashi, Leverson, Joel D, Souers, Andrew J, Hata, Aaron N, Boikos, Sosipatros, Yatabe, Yasushi, Ebi, Hiromichi, Faber, Anthony C

“…EGFR inhibitors (EGFRi) are effective against -mutant lung cancers. The efficacy of these drugs, however, is mitigated by the outgrowth of resistant cells,…”
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Exploiting endogenous and therapy-induced apoptotic vulnerabilities in immunoglobulin light chain amyloidosis with BH3 mimetics by Fraser, Cameron S., Spetz, Johan K. E., Qin, Xingping, Presser, Adam, Choiniere, Jonathan, Li, Chendi, Yu, Stacey, Blevins, Frances, Hata, Aaron N., Miller, Jeffrey W., Bradshaw, Gary A., Kalocsay, Marian, Sanchorawala, Vaishali, Sarosiek, Shayna, Sarosiek, Kristopher A.

“…Immunoglobulin light chain (AL) amyloidosis is an incurable hematologic disorder typically characterized by the production of amyloidogenic light chains by…”
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Mitochondria- and caspase-dependent cell death pathway involved in neuronal degeneration in diabetic retinopathy by Oshitari, T, Yamamoto, S, Hata, N, Roy, S

“…Neuronal abnormalities are associated with the pathogenesis of diabetic retinopathy. However, the mechanisms for neuronal cell death in diabetic retinopathy…”
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Targeting the DNA replication stress phenotype of KRAS mutant cancer cells by Al Zubaidi, Tara, Gehrisch, O. H. Fiete, Genois, Marie-Michelle, Liu, Qi, Lu, Shan, Kung, Jong, Xie, Yunhe, Schuemann, Jan, Lu, Hsiao-Ming, Hata, Aaron N., Zou, Lee, Borgmann, Kerstin, Willers, Henning

“…Mutant KRAS is a common tumor driver and frequently confers resistance to anti-cancer treatments such as radiation. DNA replication stress in these tumors may…”
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Failure to Induce Apoptosis via BCL-2 Family Proteins Underlies Lack of Efficacy of Combined MEK and PI3K Inhibitors for KRAS-Mutant Lung Cancers by HATA, Aaron N, YEO, Alan, MINO-KENUDSON, Mari, WONG, Kwok-Kin, ENGELMAN, Jeffrey A, FABER, Anthony C, LIFSHITS, Eugene, ZHAO CHEN, CHENG, Katherine A, WALTON, Zandra, SAROSIEK, Kristopher A, LETAI, Anthony, HEIST, Rebecca S

“…Although several groups have demonstrated that concomitant use of MEK and phosphoinositide 3-kinase (PI3K) inhibitors (MEKi/PI3Ki) can induce dramatic tumor…”
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Intravoxel Incoherent Motion MR Imaging of Pediatric Intracranial Tumors: Correlation with Histology and Diagnostic Utility by Kikuchi, K, Hiwatashi, A, Togao, O, Yamashita, K, Kamei, R, Momosaka, D, Hata, N, Iihara, K, Suzuki, S O, Iwaki, T, Honda, H

“…Intravoxel incoherent motion imaging, which simultaneously measures diffusion and perfusion parameters, is promising for brain tumor grading. However,…”
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Structural and Biochemical Characterization of Levan Produced by Gluconobacter cerinus UELBM11 Isolated from Brazilian Grapes by N. Y. Hata, Natália, Sartori, Daniele, M. Ribeiro, Matheus, V. Serrato, Rodrigo, B. Tomal, Adriana Aparecida, Constantino, Leonel Vinícius, A. Q. Cancian, Mariana, A. Marques, Francisco, T. Hata, Fernando, H. Bana, Fernanda Carla, Macedo Jr, Fernando, Spinosa, Wilma Aparecida

“…Acetic acid bacteria (AAB) are versatile organisms that catalyze the conversion of a wide range of carbon sources into biomolecules of great industrial…”
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A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors by Slyper, Michal, Porter, Caroline B. M., Ashenberg, Orr, Waldman, Julia, Drokhlyansky, Eugene, Wakiro, Isaac, Smillie, Christopher, Smith-Rosario, Gabriela, Wu, Jingyi, Dionne, Danielle, Vigneau, Sébastien, Jané-Valbuena, Judit, Tickle, Timothy L., Napolitano, Sara, Su, Mei-Ju, Patel, Anand G., Karlstrom, Asa, Gritsch, Simon, Nomura, Masashi, Waghray, Avinash, Gohil, Satyen H., Tsankov, Alexander M., Jerby-Arnon, Livnat, Cohen, Ofir, Klughammer, Johanna, Rosen, Yanay, Gould, Joshua, Nguyen, Lan, Hofree, Matan, Tramontozzi, Peter J., Li, Bo, Wu, Catherine J., Izar, Benjamin, Haq, Rizwan, Hodi, F. Stephen, Yoon, Charles H., Hata, Aaron N., Baker, Suzanne J., Suvà, Mario L., Bueno, Raphael, Stover, Elizabeth H., Clay, Michael R., Dyer, Michael A., Collins, Natalie B., Matulonis, Ursula A., Wagle, Nikhil, Johnson, Bruce E., Rotem, Asaf, Rozenblatt-Rosen, Orit, Regev, Aviv

“…Single-cell genomics is essential to chart tumor ecosystems. Although single-cell RNA-Seq (scRNA-Seq) profiles RNA from cells dissociated from fresh tumors,…”
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